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H. Kenneth Spencer

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Publication

Featured researches published by H. Kenneth Spencer.

Tetrahedron Letters | 1988

A variant of the Bruylants reaction. Synthesis of 4-heteroaryl-4-anilinopiperidines

Linas V. Kudzma; H. Kenneth Spencer; Sherry A. Severnak

Abstract Imines can be generated in situ from α-aminonitriles and efficiently trapped by a variety of lithiated heterocycles. This variation of the Bruylants reaction has proven to be a general method for the synthesis of α-heteroaryl secondary amines.

Journal of Medicinal Chemistry | 1989

4-Phenyl- and 4-heteroaryl-4-anilidopiperidines. A novel class of analgesic and anesthetic agents

Linas V. Kudzma; Sherry A. Severnak; Mark J. Benvenga; Edward F. Ezell; Michael H. Ossipov; Valerie V. Knight; Frieda G. Rudo; H. Kenneth Spencer

Medicinal Research Reviews | 1991

Evolution of the 4‐anilidopiperidine class of opioid analgesics

Jerome R. Bagley; Linas V. Kudzma; Nhora Lucia Lalinde; John A. Colapret; Bao-Shang Huang; Bor-Sheng Lin; Thomas P. Jerussi; Mark J. Benvenga; Brian M. Doorley; Michael H. Ossipov; H. Kenneth Spencer; Frieda G. Rudo; Richard Wynn

Journal of Medicinal Chemistry | 1991

New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics

Jerome R. Bagley; Sheela A. Thomas; Frieda G. Rudo; H. Kenneth Spencer; Brian M. Doorley; Michael H. Ossipov; Thomas P. Jerussi; Mark J. Benvenga

Archive | 1990

N-heterocyclic-N-(4-piperidinyl) amides and pharmaceutical compositions and methods employing such compounds

Jerome R. Bagley; H. Kenneth Spencer

Archive | 1990

N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds.

Jerome R. Bagley; Nhora Lucia Lalinde; Bao-Shan Huang; H. Kenneth Spencer

Journal of Medicinal Chemistry | 1990

Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics

Nhora Lucia Lalinde; John Moliterni; Denny Wright; H. Kenneth Spencer; Michael H. Ossipov; Frieda G. Rudo

Archive | 1990

N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds

Nhora Lucia Lalinde; John Moliterni; H. Kenneth Spencer

Archive | 1989

N-heterocyclic-N-(4-piperidinyl)amides and pharmaceutical compositions and their use as analgesics

Jerome R. Bagley; H. Kenneth Spencer

Archive | 1988

N-heterocyclic-n-(4-piperidyl) amides

Jerome R. Bagley; H. Kenneth Spencer

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Jerome R. Bagley

University of Mississippi

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Frieda G. Rudo

University of Maryland

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Michael H. Ossipov

University of Arizona

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Mark J. Benvenga

Uniformed Services University of the Health Sciences

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Richard Wynn

University of Maryland

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Thomas P. Jerussi

Rutgers University

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