Hans Hans Wyss

Long-range repulsion of colloids driven by ion exchange and diffusiophoresis

Significance The ability to displace particles or solutes relative to a background liquid is of central importance to technologies such as filtration/separation, chromatography, and water purification. Such behavior is observed in so-called exclusion zone formation, an effect where particles are pushed away from a surface over long distances of up to hundreds of micrometers. However, it is still unclear which physical mechanisms are responsible. Our work provides a detailed understanding of this exclusion zone formation, enabling a precise control of the behavior. This could be exploited, for instance, for sorting in microfluidic devices, in advanced antifouling coatings, or for elucidating biological processes where it is likely to play an important, yet unexplored role. Interactions between surfaces and particles in aqueous suspension are usually limited to distances smaller than 1 μm. However, in a range of studies from different disciplines, repulsion of particles has been observed over distances of up to hundreds of micrometers, in the absence of any additional external fields. Although a range of hypotheses have been suggested to account for such behavior, the physical mechanisms responsible for the phenomenon still remain unclear. To identify and isolate these mechanisms, we perform detailed experiments on a well-defined experimental system, using a setup that minimizes the effects of gravity and convection. Our experiments clearly indicate that the observed long-range repulsion is driven by a combination of ion exchange, ion diffusion, and diffusiophoresis. We develop a simple model that accounts for our data; this description is expected to be directly applicable to a wide range of systems exhibiting similar long-range forces.

Towards the self-assembly of anisotropic colloids: Monodisperse oblate ellipsoids

We present a robust and straightforward method for producing colloidal particles of oblate ellipsoidal shape via thermo/mechanical stretching of elastomeric films with embedded spherical particles. Our method produces uniformly sized and shaped colloidal particles. The method can be used for producing biaxially stretched particles of different aspect ratios and volumes; moreover, the method has a higher yield and batch size than previously reported methods for producing non-spherical particles via film stretching. These particles are ideal model systems for studying the self-assembly and gel formation for systems with anisotropic shapes and interactions. We illustrate this by adding of a non-adsorbing polymer to the solvent, thereby inducing directional depletion interactions between the particles.

Cell mechanics : combining speed with precision

The mechanical response of cells is a powerful biophysical marker for cell state. Information on a cell’s elasticity can, for instance, be used to distinguish between different cell phenotypes, or between healthy and diseased cells.

Kinetic model for the mechanical response of suspensions of sponge-like particles

A dynamic two-scale model is developed that describes the stationary and transient mechanical behavior of concentrated suspensions made of highly porous particles. Particularly, we are interested in particles that not only deform elastically, but also can swell or shrink by taking up or expelling the viscous solvent from their interior, leading to rate-dependent deformability of the particles. The fine level of the model describes the evolution of particle centers and their current sizes, while the shapes are at present not taken into account. The versatility of the model permits inclusion of density- and temperature-dependent particle interactions, and hydrodynamic interactions, as well as to implement insight into the mechanism of swelling and shrinking. The coarse level of the model is given in terms of macroscopic hydrodynamics. The two levels are mutually coupled, since the flow changes the particle configuration, while in turn the configuration gives rise to stress contributions, that eventually determine the macroscopic mechanical properties of the suspension. Using a thermodynamic procedure for the model development, it is demonstrated that the driving forces for position change and for size change are derived from the same potential energy. The model is translated into a form that is suitable for particle-based Brownian dynamics simulations for performing rheological tests. Various possibilities for connection with experiments, e.g. rheological and structural, are discussed.