Harish Sehdev

Comparison of the efficiency of second-trimester nasal bone hypoplasia and increased nuchal fold in Down syndrome screening.

OBJECTIVEnThe purpose of this study was to compare the efficiency of second-trimester nasal bone hypoplasia (NB) and increased nuchal fold (NF) in Down syndrome screening.nnnSTUDY DESIGNnThis was a prospective multicenter cohort study of women who underwent an anatomic survey between 16 and 22 weeks of gestation. The fetal NB and other markers of fetal aneuploidy that included NF were evaluated. NB was defined either as an absent NB or length of <0.75 multiples of the median for the gestational age. Two definitions of increased NF (>5 mm and >6 mm) were evaluated. Fetuses or infants with Down syndrome were compared with those fetuses without for the presence of NB and increased NF.nnnRESULTSnAmong 4373 pregnancies that were evaluated over a 5-year period, there were 50 pregnancies with Down syndrome. NB evaluation was obtained in 3936 of 4373 pregnancies (90%); NF was evaluated in all of the fetuses. Absent NB was seen in 14/49 cases (29%), and NF of >6 mm was seen in 6 of 50 cases (12%) with Down syndrome.nnnCONCLUSIONnNasal bone and nuchal fold are efficient markers for Down syndrome. Absent nasal bone was a better predictor of Down syndrome, compared with nuchal fold, and should be a standard marker when a second-trimester genetic sonogram is performed.

Can transabdominal ultrasound identify women at high risk for short cervical length

To determine whether transabdominal cervical length screening could identify women at high risk for having a short cervix on transvaginal ultrasound.

OC053: The efficiency of second-trimester nasal bone (NB) hypoplasia as a Down syndrome marker in low versus high-risk groups

treatment. The enhanced area of 62 lesions i 66.7% j was a bit larger than that of the 2D measurement. In 3 cases, the post-treatment CEUS showed no obvious ablated area within the tumor, who were given another HIFU treatment once with increased therapeutic dosage. The average ablation volume (without enhancement in CEUS) of the leiomyomas after HIFU treatment was 82.9% ± 19%. The mean volume of the tumors was 60.0% ± 29.1% (P < 0.05) decreased compared with that of the pre-treatment, 6 months later. Symptoms of all cases improved or disappeared after treatment. There was no serious side-effect of the treatment observed. Conclusions: CEUS can visualize the circulatory condition of the tumor and thus play an important role in HIFU treatment of uterine leiomyomas.

OC8.05: The association between the Biparietal diameter and Nasal bone ratio (BPD/NB) and fetal aneuploidy in pregnancies between 15–22 weeks gestation

Objective: Our objective is to evaluate the efficiency of BPD/NB ratio as an independent marker for fetal aneuploidy. Methods: Prospective cohort study of women presenting for anatomic survey between 15 and 22 weeks of gestation. The fetal nasal bone (NB) and other markers of fetal aneuploidy including: nuchal fold, femur (FL) and humeral (HL) lengths, choroid plexus cysts, major fetal anomaly, echogenic bowel, pyelectasis and hypoplastic fifth digits, were evaluated. NB hypoplasia was defined as a BPD/NB ratio > 11. Short FL and HL were defined as measurements 11.0 is a marker for fetal aneuploidy. However, as an isolated marker, the efficiency of nasal bone hypoplasia as an isolated marker is modest.