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Harri Hakala

University of Turku

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Publication

Featured researches published by Harri Hakala.

Letters in Organic Chemistry | 2009

Labeling of Oligopeptides with Luminescent Lanthanide(III) Chelates on Solid Phase

Jari Peuralahti; Lassi Jaakkola; Harri Hakala; Veli-Matti Mukkala; Jari Hovinen

Synthesis of a building block based on 6,6’-(1H-pyrazole-1,3-diyl)bis(pyridine) (3) that allows introduction of photoluminescent lanthanide(III) chelates to the synthetic oligopeptides on solid phase using the standard Fmoc chemistry is described. Since the ligand based on (3) forms luminescent chelates with Eu, Sm, Tb and Dy ions, the ligand is highly useful for multiparametric homogenous assays simplifying considerably the preparation of chelates needed in these applications.

Bioconjugate Chemistry | 1999

AMINOOXY FUNCTIONALIZED OLIGONUCLEOTIDES : PREPARATION, ON-SUPPORT DERIVATIZATION, AND POSTSYNTHETIC ATTACHMENT TO POLYMER SUPPORT

Harri Salo; Harri Hakala; Thazha P. Prakash; Andrei M. Kawasaki; Muthiah Manoharan; Harri Lönnberg

Nucleic Acids Research | 1998

Simultaneous detection of several oligonucleotides by time-resolved fluorometry: The use of a mixture of categorized microparticles in a sandwich type mixed-phase hybridization assay

Harri Hakala; Harri Salo; Harri Lönnberg

Bioconjugate Chemistry | 1997

Time-Resolved Fluorescence Detection of Oligonucleotide Hybridization on a Single Microparticle: Covalent Immobilization of Oligonucleotides and Quantitation of a Model System

Harri Hakala; Harri Lönnberg

Bioconjugate Chemistry | 2002

Introduction of lanthanide(III) chelates to oligopeptides on solid phase.

Jari Peuralahti; Harri Hakala; Veli-Matti Mukkala; Kristiina Loman; Pertti Hurskainen; Outi Mulari; Jari Hovinen

Clinical Chemistry | 1997

Sensitive bioaffinity assays with individual microparticles and time-resolved fluorometry

Timo Lövgren; Pia Heinonen; Päivi Lehtinen; Harri Hakala; Johanna Heinola; Raimo Harju; Harri Takalo; Veli-Matti Mukkala; Ruth Schmid; Harri Lönnberg; Kim Pettersson; Antti Iitiä

Bioconjugate Chemistry | 1997

DETECTION OF OLIGONUCLEOTIDE HYBRIDIZATION ON A SINGLE MICROPARTICLE BY TIME-RESOLVED FLUOROMETRY: HYBRIDIZATION ASSAYS ON POLYMER PARTICLES OBTAINED BY DIRECT SOLID PHASE ASSEMBLY OF THE OLIGONUCLEOTIDE PROBES

Harri Hakala; Pia Heinonen; Antti Iitiä; Harri Lönnberg

Archive | 2004

Novel chelating agents and chelates and their use

Jari Hovinen; Veli-Matti Mukkala; Harri Hakala; Jari Peuralahti

Archive | 2004

Chelating agents and highly luminescent and stable chelates and their use

Jari Hovinen; Veli-Matti Mukkala; Harri Hakala; Jari Peuralahti

Bioconjugate Chemistry | 2005

Solid-phase synthesis of oligonucleotides labeled with luminescent lanthanide(III) chelates.

Lassi Jaakkola; Jari Peuralahti; Harri Hakala; Jenni Kunttu; Pekka Tallqvist; Veli-Matti Mukkala; and Alice Ylikoski; Jari Hovinen

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Collaboration

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Veli-Matti Mukkala

University of Turku

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Harri Lönnberg

University of Turku

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Jari Hovinen

University of Turku

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Jari Peuralahti

PerkinElmer

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Kaj Blomberg

Åbo Akademi University

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Ilkka Hemmilä

PerkinElmer

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Lassi Jaakkola

PerkinElmer

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Pertti Hurskainen

PerkinElmer

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Pia Ollikka

PerkinElmer

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Alice Ylikoski

University of Turku

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