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Harriet W. Hamilton

Pfizer

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Publication

Featured researches published by Harriet W. Hamilton.

Bioorganic & Medicinal Chemistry Letters | 2002

Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring.

Harriet W. Hamilton; Gisele Nishiguchi; Susan Elizabeth Hagen; John Domagala; Peter Weber; Stephen J. Gracheck; Stefanie L Boulware; Eric C. Nordby; Hidetsura Cho; Takeshi Nakamura; Satoru Ikeda; Wataru Watanabe

A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.

Journal of Medicinal Chemistry | 1992

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors

William Chester Patt; Harriet W. Hamilton; Michael Douglas Taylor; Michael J. Ryan; David G. Taylor; Cleo Connolly; Annette M. Doherty; Sylvester R. Klutchko; Ila Sircar

Archive | 1987

N6-substituted Adenosines

Alexander James Bridges; Harriet W. Hamilton; Walter H. Moos; Deedee L. Szotek

Journal of Medicinal Chemistry | 1987

Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists.

Harriet W. Hamilton; Daniel F. Ortwine; Donald F. Worth; James A. Bristol

Archive | 1989

Renin inhibitors, method for using them, and compositions containing them

Annette Marian Doherty; Harriet W. Hamilton; John C. Hodges; Joseph Thomas Repine; Ila Sircar

Journal of Medicinal Chemistry | 1985

Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.

Harriet W. Hamilton; Daniel F. Ortwine; Donald F. Worth; Edward W. Badger; James A. Bristol; Robert F. Bruns; Stephen J. Haleen; Robert P. Steffen

Journal of Medicinal Chemistry | 1997

4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease

Bradley D. Tait; Susan Elizabeth Hagen; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Harriet W. Hamilton; J. V. N. Vara Prasad; Donna Ferguson; Neil Graham; Donald Hupe; Carolyn Nouhan; Peter J. Tummino; Christine Humblet; Elizabeth A. Lunney; Alexander Pavlovsky; John R. Rubin; Stephen J. Gracheck; Eric T. Baldwin; T. N. Bhat; John W. Erickson; and Sergei V. Gulnik; Beishan Liu

Journal of Medicinal Chemistry | 1997

Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors : The profound effect of polarity on antiviral activity

Susan Elizabeth Hagen; J.V.N. Vara Prasad; Frederick E. Boyer; John M. Domagala; Edmund L. Ellsworth; Christopher Gajda; Harriet W. Hamilton; Larry J. Markoski; Bruce A. Steinbaugh; Bradley D. Tait; Elizabeth A. Lunney; Peter J. Tummino; Donna Ferguson; Donald Hupe; Carolyn Nouhan; Stephen J. Gracheck; James M. Saunders; Steven VanderRoest

Journal of Medicinal Chemistry | 1986

Ribose-modified adenosine analogues as adenosine receptor agonists

Michael D. Taylor; Walter H. Moos; Harriet W. Hamilton; Deedee S. Szotek; William Chester Patt; Edward W. Badger; James A. Bristol; Robert F. Bruns; Thomas G. Heffner; Thomas E. Mertz

Archive | 1986

Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor

Edward W. Badger; Harriet W. Hamilton

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William Chester Patt

Pfizer

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Bharat Trivedi

Ohio State University

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James A. Bristol

University of New Hampshire

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Alexander James Bridges

Pfizer

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Robert F. Bruns

Eli Lilly and Company

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Susan Elizabeth Hagen

Pfizer

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Bradley D. Tait

Pfizer

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Cleo Connolly

Pfizer

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Stephen J. Gracheck

Pfizer

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Annette M. Doherty

Pfizer

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