Haruki Wakasa

Some problems on the histopathological diagnosis of non-Hodgkin's malignant lymphoma -- a proposal of a new type.

A new classification for non‐Hodgkins malignant lymphoma is proposed as the one suited for the Lymphomas in Japan, which is to provide a new subtype “pleomorphic” for those more or less rapid‐growing lymphomas of peripheral T‐cell nature, along with another subtype lymphoblastic, after Nathwani et al. for those of central T‐cell nature. The proposal is based on the result of the investigation by the Study Group for Histopathological Diagnosis on Malignant Lymphoma that (1) the presence of a significant number of T‐cell lymphomas with peculiar “pleomorphism” is responsible for the very low reproducibility rate of histopathological diagnosis on the diffuse, mixed L&H type of Rappaport classification, and (2) the relative incidence of lymphoms of peripheral T‐cell nature including the so‐called adult T‐cell leukemia is much higher in Japan than in the Western countries.

Cutaneous T cell lymphoma associated with recurrent panniculitis and reactive histiocytosis.

As is the case in other areas of research where advances in basic science have changed concepts in clinical medicine, it has become evident that clinical or morphological criteria alone no longer suffice to classify lymphocytic neoplasms. A definition of the subclass of the cells involved, their immunocytochemical characteristics, and their original role in the immune system appears necessary to arrive at more accurate diagnosis, prognosis, and more appropriate treatment for this group of diseases.

Cytological Findings of Leiomyoma and Leiomyosarcoma of the Stomach

The purpose of this study is to compare cytological findings of leiomyoma and leiomyosarcoma of the stomach. The two groups of 7 cases with leiomyoma and 4 cases with leiomyosarcoma were analysed Cytological materials were obtained by direct smear method from surgical specimen, and observed microscopically under 1000×magnification with Pap. staining.1. leiomyoma cells: The means of the minor axis diameter of nuclei was found to be 4.6μ and narrowly distributed. Nuclei were cigar-shaped with rounded tips and contained normally stained granular chromocenters.2. leiomyosarcoma cells: Nuclei of most cells were oval or rounded shaped and pleomorphic, containing deeply stained granular chromocenters and clumpy chromocenters.The means of minor axis diameter was 7.5μ and showed a wide scattered distribution pattern.It may be concluded that differential diagnosis by these cytological findings between leiomyoma and leiomyosarcoma could be made.