Haruyasu Sawami

OBSERVATIONS ON ALLERGIC ENCEPHALITIS EXPERIMENTALLY PRODUCED BY THE USE OF GRAY MATTER PHOSPHATIDE

According to the r e p r t of Cenfani i i.l]i, Miyagatcw and I s h i i (2), and Koritschner apd Schtoeinburg (3), certain symptoms of the central nervous system are produced when brain tissue is injected into animals. In 1932, Hurst discovered that paralysis is often the outcome of repeated subcutaneous or intramuscular injection of the brain emulsion in rabbits. Rivers , Sprzoat and Berry (4) observed in 3933 that upon intramuscular injection of the emulsion and the alcoholic extract of rabbits’ brains into monkeys, symptoms of the central nervous system will ensue, with inflammation or the nervous system, accompanied by perivascular demyelination a s histological representation. In 1935 R i w r s and Schwentkcr’ ( 5 ) , on the basis of the idea of this experiment, conststed clinically ptosis, masklike facies, facial paralysis, abnormal posture of the head, blindness, and ataxia. They added, thereafter, in reference to histological symptoms, perivascular hyperplasia of niicroglia cells, and’infiltration of mononuclear cells 3s we!l as of multinuclear leucocytes, while also admitting the appearance of hemorrhagic lesion and perivascular demyelinstion in the progressive stage. Ferraro’s and Jert:is’ (\6) retest also confirmed these findings. Morgan in 1946, and Kabat , WoZ f and Bezar in 1946, using Freund’s adjuvant together with homologous or heterologous nerve tissue, succeeded in reducing the incubation period up to the outbreak of the acute disseminated encephrllomyelitis in monkeys. In 1947 Morrison (7 I repeated subcutaneous and intraperitonal injection of autohydrolysed suspension of the spinal cord, etc. producing again symptoms of the central nervous system. Histologically there were found perivascular reactions of hematogenous cells m d interstitial cells, followed by demyelination, ~