Harvey Krieger

A comparative study of blood volume in dogs.

Conclusion 1. A comparison of 3 methods for the determination of blood volume was made on 10 dogs. 2. The average blood volumes expressed as per cent of body weight for the 3 methods were: T-1824, 10.5%; for red cells tagged with P32, 9.7%; and iodinated protein, 9.4%. 3. The iodinated protein method permitted accurate determinations of plasma volumes for a much longer period after injection than did the other two methods. This method was simple and direct. It permitted calculation of the volume within a few minutes after the samples were obtained. It appeared to have a decided advantage over blood volume estimation with P32 impregnated red blood cells and the T-1824 dye method.

I131-labeled serum albumin: its use in the study of cardiac output and peripheral vascular flow.

During the past several years a method for measuring plasma volumes has been under investigation in our laboratory (1, 2). This method involved the use of a tagged serum protein (I131-tagged albumin) and gave promising results which appeared useful. It became obvious that the slow rate of disappearance of tagged albumin from the blood would make this a satisfactory substance for the study of vascular flow measurements. Before this could be achieved, however, it was necessary to develop a number of instruments which would make it possible to detect small amounts of radioactivity by their gamma emission and to record the events rapidly enough so that critical alterations in dilution and mixing of the radioactive albumin could be recorded. The essence of the method which will be described concerns itself with measuring and recording the manner and rate in which iodinated plasma is mixed and diffused through the blood. The character of the curve which is obtained on isolated arteries has proved suitable for q...

Appearance of Protein Tagged with Radioactive Iodine in Thoracic Duct Lymph

Conclusions 1. The total lymph volume is not measurable, so that the exact amount of activated protein that is present in the body lymph, following intravenous injection of iodinated protein, cannot be calculated. However, it appears from this experiment that a negligible amount is present in the thoracic duct lymph 10 minutes after injection. 2. During the first hour there is a rapid increase in the lymph content of radioactive protein followed by a more gradual rise.

Palliation of Osseous Metastases from Breast Carcinoma with Radioactive Phosphorus Alone and in Combination with Adrenalectomy

The palliation of metastasizing carcinoma of the breast presents a tremendous problem to the clinician. Several therapeutic approaches have been proposed. Just before the turn of the century Schinzinger (12) and Beatson (1) showed that oophorectomy produced beneficial effects in premenopausal patients. In 1939 Ulrich (13) and Loeser (8) demonstrated that testosterone was beneficial in the palliation of bone metastases, and in 1944 estrogen was first used in postmenopausal women with metastases from carcinoma of the breast. Irradiation is the treatment of choice for local recurrences of mammary cancer and for isolated bone metastases. In almost every case, however, the disease eventually becomes so widespread that external radiation therapy is no longer practical. In 1950, two of the present authors (4) reported on the use of radioactive phosphorus for the treatment of widespread osseous metastases from carcinoma of the breast. They obtained subjective relief of pain in approximately three-fourths of the p...

SOME ASPECTS OF VASCULAR DISEASE OF THE SMALL INTESTINE.

VASCULAR compromise of the intestine may produce a broad spectrum of pathologic change; corresponding roentgen patterns are not specific for a given disease but reflect the stage of compromise. These patterns have been the subject of a previous paper (30). Recognition of an increasing number of cases of noncatastrophic vascular involvement of the small bowel has focused attention on their importance. Our experience would indicate that such minor insults are far more frequent than superior mesenteric occlusion. Some clinical, pathologic, and experimental aspects of this problem are presented in this paper. Arterial or arteriolar insufficiency and venous obstruction, congestion, and resultant oxygen deprivation may vary in degree. Similarly, the segment of small bowel involved may vary in length. The end-result depends upon an interplay between these factors and the collateral blood supply. Of all the intestinal layers, the mucosa is most sensitive to ischemia; therefore the earliest and mildest changes res...

THE RÔLE OF ACTH, CORTISONE AND HYDROCORTISONE IN SURGERY

Excerpt During the past few years a considerable amount of knowledge concerning the use and abuse of ACTH, cortisone and hydrocortisone in the treatment of surgical patients has accumulated. Metabo...