Hayati Güneş
Namik Kemal University
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Featured researches published by Hayati Güneş.
Toxicology and Industrial Health | 2016
Hayati Güneş; Dumrul Gulen; Reyhan Mutlu; Abdullah Gumus; Tekin Tas; Aynur Eren Topkaya
Aim: To evaluate the antibacterial effect of curcumin with the minimum inhibitory concentration (MIC) method in standard bacterial strains. Methods: The in vitro antibacterial activity of curcumin was evaluated against methicillin-sensitive Staphylococcus aureus (MSSA) (ATCC 29213), methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 6633), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922) and Klebsiella pneumoniae (ATCC 700603) using the macrodilution broth susceptibility test method. After incubation in tubes, the antibacterial activity of curcumin was detected by a lack of turbidity, which indicated the inhibition of bacterial growth. The concentration in the tube with the highest dilution showing no turbidity was defined as the MIC. Results: The curcumin MIC values were 175 µg/ml, 129 µg/ml, 219 µg/ml, 217 µg/ml, 163 µg/ml, 293 µg/ml and 216 µg/ml against P. aeruginosa, B. subtilis, MSSA, MRSA, E. coli, E. faecalis and K. Pneumonia, respectively. Conclusion: This study revealed antibacterial effects of curcumin against standard bacterial strains in high concentrations. Animal experiments have demonstrated that curcumin applied at high doses has strong antibacterial activity. There is a need for further in vivo studies to shed light on antibacterial effects of curcumin with high concentrations.
International Journal of General Medicine | 2016
Ilknur Erdem; Senay Elbasan Omar; Ridvan Kara Ali; Hayati Güneş; Aynur Eren Topkaya
Objective Infections are among the most important causes of morbidity and mortality in patients with systemic lupus erythematosus (SLE) but are rare initial presentation of the disease. Therefore, in this study, we describe a case of Streptococcus pneumoniae sepsis in a young woman with previously undiagnosed SLE. Case report A 23-year-old female patient was admitted to our outpatient clinic complaining of high fever (40°C), chills, fatigue, generalized myalgia, and cough with brown sputum for 5 days. Blood cultures grew gram-positive coccus defined as S. pneumoniae using standard procedures. Antinuclear antibody was positive at a titer of 1/1,000, and anti-double-stranded DNA was positive at 984 IU/mL. She was diagnosed with SLE. Her respiratory symptoms and pleural effusion were considered to be due to pulmonary manifestation of SLE. Conclusion The underlying immunosuppression caused by SLE could have predisposed the patient to invasive pneumococcal disease. It may also occur as a primary presenting feature, although a rare condition.
ANKEM Dergisi | 2014
Omer Kurt; Hayati Güneş; Abdullah Gumus; Reyhan Mutlu; Aynur Eren Topkaya
Escherichia coli, üriner sistem infeksiyonlarından (ÜSİ) en sık izole edilen mikroorganizmadır. Son zamanlarda ülkemizde üropatojen E.coli suşlarında, ÜSİ tedavisinde sık kullanılan antibiyotiklere karşı duyarlılıkta azalma görülmektedir. Bu çalışmada, ÜSİ ön tanısıyla üroloji polikliniğinden gönderilen idrar kültürlerinden izole edilen E.coli suşlarının siprofloksasin, nitrofurantoin ve fosfomisin duyarlılıkları, Clinical and Laboratory Standards Institute (CLSI) önerileri doğrultusunda disk difüzyon yöntemi ile belirlenmiş; genişlemiş spektrumlu beta-laktamaz (ESBL) üretimi çift disk sinerji yöntemiyle araştırılmıştır. İncelenen E.coli izolatlarında en yüksek direnç oranı % 32.1 ile siprofloksasine karşı saptanmış, bunu % 5.1 ile nitrofurantoin ve % 4.5 ile fosfomisin takip etmiştir. ESBL pozitiflik oranı % 22.5 olarak tespit edilmiştir. Direnç oranları ESBL pozitif ve negatiflerde sırasıyla siprofloksasine karşı % 85.3 ve % 17.3 nitrofurantoine karşı % 12.6 ve % 2.9, fosfomisine karşı ise % 13.9 ve % 1.9 olarak saptanmıştır. Bölgemizde siprofloksasine direnç oranında yükselme gözlenmesine karşın fosfomisin ve nitrofurantoin, ÜSİ tedavisinde iyi birer alternatif olmayı sürdürmektedir.
Libyan Journal of Medicine | 2013
Hayati Güneş; Mustafa Dogan
Brucellosis is a zoonotic disease caused by Brucella spp. and is still a serious problem of public health for some regions around the world such as the Mediterranean Sea, Middle East, Latin America, and Asia. (Published: 14 February 2013) Citation: Libyan J Med 2013, 8 : 20417 - http://dx.doi.org/10.3402/ljm.v8i0.20417
Bozok Tıp Dergisi | 2012
Hayati Güneş; Mustafa Dogan
Agri Devlet Hastanesi’nde 2006-2009 Yillarinda Saptanan Intestinal Parazit Prevalans ve Dagilimi
Medical Science and Discovery | 2015
Zafer Ciftci; Mahmut Deniz; Hayati Güneş; Abdullah Gumus; Erdogan Gultekin; Aynur Eren Topkaya
Journal of Medical Cases | 2015
Ilknur Erdem; Mucahit Dogru; Seyfi Emir; Ridvan Kara Ali; Senay Elbasan; Reyhan Mutlu; Hayati Güneş; Aynur Eren Topkaya
International Journal of Basic and Clinical Medicine | 2015
Hayati Güneş; Remzi Altın; Levent Cem Mutlu; Mustafa Dogan; Mustafa Oran; Salman Işık; Gürdal Salt; Ayşe Demet Kaya
International Journal of Basic and Clinical Medicine | 2014
Levent Cem Mutlu; Remzi Altın; Hayati Güneş; Mustafa Dogan; Mustafa Oran; Salman Işık; Gürdal Salt; Ayşe Demet Kaya
Genel Tip Dergisi | 2014
Mustafa Oran; Hayati Güneş; Oguzhan Yildirim; Meltem Oznur; Tuncay Koç; İbrahim Gelincik; Rafet Mete