Heikki Ruotsalainen

Iodinated melatonin: preparation and characterization of the molecular structure by mass and 1H NMR spectroscopy.

Synthetic melatonin was iodinated by treatment with potassium iodide in the presence of an oxidizing agent, Iodo-Gen. The iodination products of melatonin were extracted with chloroform and separated by HPLC. The fraction showing immunoreactivity with respect to melatonin antisera was characterized as iodomelatonin by mass spectrometry, so that the substitution of iodine had occurred at a ring carbon atom. 1H NMR spectra showed the iodine to be incorporated at the C-2 position of the indole moiety. The N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide (2-iodomelatonin) reported here is more useful than [3H]melatonin as a tracer in melatonin radioimmunoassay. This method offers also the possibility of preparing iodinated serotonin and other indoleamines for biological studies.

Thermal decomposition of hydrated copper(II) 5-substituted salicylates

Abstract Trihydrates of copper(II) 5-chloro-, copper(II) 5-bromo-, and copper(II) 5-iodosalicylates and dihydrate of copper(II) 5-nitrosalicylate have been prepared and characterized on the basis of elemental analysis and IR studies. The thermal behaviour of these salicylate hydrates has been determined employing TG, DTG and DSC techniques. The decomposition reaction mechanism of these complexes was studied by analyzing the decomposition products with MS and IR spectroscopy. CuO has been detected as the final product in the decomposition processes.

Kinetic and mechanistic studies on the decomposition of some hydrous iron(II) salicylato complexes

Abstract Hydrous iron(II) salicylate, iron(II) 5-chloro-, iron(II) 5-bromo-, iron(II) 5-iodo-, and iron(II) 5-nitrosalicylato complexes have been prepared and their mode of thermal decomposition investigated by thermogravimetry, differential scanning calorimetry, and mass spectrometry. The results show that the decomposition of the compounds occurs in three stages and the final product, at about 700–773 K, is Fe2O3 for all complexes. The kinetics and thermodynamics of the isothermal dehydration of the complexes were studied by thermogravimetry and differential scanning calorimetry. The dehydration process seems to follow most closely a phase boundary reaction mechanism.

The spectrum of HCCF around 2200 cm−1

Abstract The i.r spectrum of HCCF in the region of the CC stretching vibration ν2 around 2200 cm−1 has been studied. The fundamental ν2 has been found to be in Fermi resonance with 2ν3, the overtone of the CF stretching band. The rotational structure of the bands has been investigated and the molecular constants involved have been derived.

Thermal decomposition of bis(1-hydroxy-4-sulfonato-2-naphthoic acid)copper(II) nonahydrate

Abstract A 1:2 copper(II) complex of 1-hydroxy-4-sulfonato-2-naphthoic acid, Cu(C11H7O6S)2 · 9H2O, has been prepared and characterized on the basis of elemental analysis and IR spectrometry. The thermal behaviour of the compound has been studied using TG, DTG and DSC techniques. The decomposition mechanism of the complex has been interpreted by analyzing the decomposition products with mass and IR spectrometry. The first three stages in the TG curve are the release of the water molecules. According to the MS spectra there are three evaporated decomposition products at 330 °C which are 1-naphthol, 1,4-naphthoquinone and phthalic anhydride. The final decomposition product is CuO.

Studies on the PMR Spectra of Oxetanes

Abstract The oxetane parts of 2-(4-methylphenyl) oxetane, 2-(2,4-dimethylphenyl)oxetane and 2-(2,4,6-tri-methylphenyl) oxetane have been analysed as the ABCDE spin systems from the 60 MHz PMR spectra. The chemical shifts and the proton-proton couplings of the protons in the oxetane rings have been solved through iterative calculations. The possible phenomena which may affect the chemical shifts and couplings have been investigated. One of the most dominating factor seems to be the non-planarity of the oxetane ring. The ring current effects of the 2-substituents and the field effects of the methyl groups shift the resonances of the oxetane ring protons.