Helmut Kaspers

TRIAZOLYL-O,N-ACETALS, CHEMISTRY, ACTIVITY AND STRUCTURE

Abstract The synthesis, biological activity and structure activity relationships of phenoxy-triazolyl-methanes are reported. The synthesis of these compounds is demonstrated for triadimefon, starting from a-chloropinacolone. The biological activity of phenoxy-triazolyl-methanes, the so-called triazolyl-0,N-acetals covers mainly protective, curative, eradicative, and systemic control of powdery mildews, scab and rust. On a series of triazolyl-0,N-acetals rnonosubstituted in the phenyl ring, Spearman rank correlation is investigated. In accordance with this rank correlation, the QSAR shows a good intercorrelation of activity of triazolyl-0,N-acetals against Erysiphe cichoracearurn in protective greenhouse tests and the lipophilicity data π, RM and Verloops sterie parameter B4.