Henri Cousse

Analyse conformationnelle CNDO/2 de nouveaux derives cyclopropaniques bifonctionnels

Resume The conformational analysis and the electronic structure of t-butyl cyclopropyl ketones are investigated within the framework of the CNDO/2 approximation; in every case, the cis isomer is found to be preferred with an unusual conformation of the substituent with respect to the cyclopropane ring. Interaction between the oxygen of OH or OCH3 substituents and the carbonyl oxygen atom is observed.

Variations in amino acid composition of phytoplanktonic production in sewage treatment ponds at Meze. Effects on the valorization of microalgal biomass

Abstract 1. 1. Fatty acids composition of phytoplankton in sewage treatment ponds of Meze evolves over time with taxonomic origins of the population. 2. 2. The major types seen in the course of an annual cycle are differentiated by the unsaturation level of their total fatty acids. 3. 3. This level is high for Bacillaryophyceae, lower for Cyanophyceae, between the two preceding levels for chlorophyceae. 4. 4. Only the fractions rich in polyunsaturated fatty acids can represent an essential constituent of feeding regime in aquaculture. 5. 5. Due to the presence of short-sequenced saturated fatty acids, reputed tobe skin irritants, liposoluble extracts of the phytoplankton represent only a limited interest for cosmetic trade.

Analyse conformationnelle theorique et activite anti-depressive de nouveaux derives cyclopropaniques bifonctionnels: Midalcipran et isomeres

Abstract (Theoretical conformational analysis and anti-depressive effectiveness of new bifunctional cyclopropanic derivatives: Midalcipran and relatives) The conformational analysis of Midalcipran, a novel anti-depressor agent, was achieved through a concerted use of the CNDO/2 quantum technique and of some new specific software for micro-computers, such as APPLE ///, which are able to design and sort preferred conformations. The anti-depressive activity is then attributed to the existence in the molecule of a “double-locked” rigid lactamic pattern highly suitable for receptor recognition.

Do glycylanilide anxiolytics need a seven-membered structure to be active? A quantum mechanical study

Abstract A theoretical conformational analysis of two glycylanilide drugs, A and B, is presented. A and B differ by only one methyl group but do not have the same therapeutic behaviour, B being a promising anxiolytic (C.D.I. code name: oxazafone) whereas A has no real activity. The effectiveness of B is demonstrated to be due to a strongly preferred cis conformation for its peptidic segment while A is characterized by a corresponding trans conformation. Thus it seems that such a cis conformation of the peptidic segment within a glycine-amide chain is necessary for the anxiolytic activity. The seven-membered ring structure of Diazepam also appears to favour this cis conformation but is not actually necessary for anxiolytic activity.

On the synthesis and chemical behaviour of itanoxone and related compounds as cholesterol-regulating drugs: A quantum mechanical investigation

Abstract Judicious use of quantum mechanical calculation leads to conclusions about how to avoid side reactions in the synthesis of Itanoxone (I).