Hermanns-Lê T

CHILDHOOD CUTANEOUS LEIOMYOSARCOMA

Abstract:u2003 Cutaneous leiomyosarcoma is a soft tissue neoplasm exhibiting an aggressive local behavior and a potential for distant metastases. It is rare during childhood and diagnosis can be challenging both clinically and histologically. Surgical excision with wide lateral and deep margins is the treatment of choice, whereas radiotherapy and chemotherapy are contraindicated. Long‐term follow‐up is necessary as recurrences are not infrequent.

Corneoxenometry: A Bioassay Exploring Skin Barrier Breaching

Some specific chemical compounds called penetration enhancers breach the skin barrier function after topical applications. It is important to predict the severity of alteration of the skin permeability barrier function. Corneoxenometry was designed as an ex vivo bioassay predicting on human stratum corneum the efficacy and the potential noxious effects of xenobiotics. The test substrate is a cyanoacrylate skin surface stripping harvested from normal or altered skin. Dose-response effects are conveniently tested while avoiding any skin hazards.

Effects of Hormone Replacement Therapy on Skin Viscoelasticity During Climacteric Aging

During perimenopause, the skin and a series of other organs become altered as prominent sex hormone declines. The natural climacteric is associated with a decline in functional properties of various tissues including viscoelasticity of the dermal connective tissue. There are many ways for assessing in vivo skin viscoelasticity, and the various procedures frequently measure distinct physical characteristics. The suction method has been selected by a majority of investigators looking at dermal functional changes during climacteric. Some women benefit from oral hormone replacement therapy (HRT) or transdermal estrogen therapy (TET) for controlling some unpleasant climacteric changes (osteoporosis, vasomotor instability, skin withering, dermal depletion in versican-hyaluronic acid, etc.). In particular, the hormonal repair exhibits some preventive and corrective effects in the functional decline of the dermal physical properties.