Hideaki Nitta
Hiroshima University
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Publication
Featured researches published by Hideaki Nitta.
Haematologica | 2015
Hideaki Nitta; Yasuhito Terui; Masahiro Yokoyama; Yuko Mishima; Noriko Nishimura; Kyoko Ueda; Yoshiharu Kusano; Naoko Tsuyama; Kengo Takeuchi; Yoshinobu Kanda; Kiyohiko Hatake
Recently, elevated peripheral blood monocyte counts at diagnosis have been shown to be an independent marker associated with poor prognosis in patients with both non-Hodgkin and Hodgkin lymphoma. In this study, we retrospectively analyzed the data from a total of 550 patients with diffuse large B-cell lymphoma and evaluated the relationship between central nervous system relapse and absolute monocyte counts at diagnosis. Twenty-six patients developed central nervous system relapse. The central nervous system relapse-free survival rate was significantly lower in patients with the absolute monocyte counts ≥0.51×109/L (87.8% versus 96.4%; P<0.001). This association was independently significant after adjusting for other significant factors, including systemic relapse as a time-dependent covariate by multivariate analysis (hazard ratio 2.46; 95% confidence intervals 1.05–5.75; P=0.039). These results suggest that the absolute monocyte count at diagnosis is an independent significant risk factor for central nervous system relapse in patients with diffuse large B-cell lymphoma.
British Journal of Haematology | 2010
Hideaki Nitta; Keichiro Mihara; Akira Sakai; Akiro Kimura
Paris), E Cheuret, I Glorieux, N Montjaux, S Lebon, JY le Tallec (Toulouse), Y Lakhdari, E Saliba (Tours), C Mignot, ML Moutard (Trousseau, Paris), N Benbrik, D Soupre (Vannes), A Cailho, C Coudy (Versailles), C Ringenbach (Villefranche sur Sâone), N Blanc, MJ Boivin, F Guillot (Villeneuve Saint-Georges) as local clinicians. D Allard, L Hertz-Pannier, B Husson (radiology), MN Varlet (obstetric), B Tardy (haemostasis).
British Journal of Haematology | 2012
Hideaki Nitta; Yuka Harada; Hideo Hyodo; Akiro Kimura; Hironori Harada
Fogarty, P.F. (2009) Chronic immune thrombocytopenia in adults: epidemiology and clinical presentation. Hematology/Oncology Clinics of North America, 23, 1213–1221. Kuter, D.J., Bussel, J.B., Lyons, R.M., Pullarkat, V., Gernsheimer, T.B., Senecal, F.M., Aledort, L.M., George, J.N., Kessler, C.M., Sanz, M.A., Liebman, H.A., Slovick, F.T., de Wolf, J.T., Bourgeois, E., Guthrie, Jr, T.H., Newland, A., Wasser, J.S., Hamburg, S.I., Grande, C., Lefre‘re, F., Lichtin, A.E., Tarantino, M.D., Terebelo, H.R., Viallard, J.F., Cuevas, F.J., Go, R.S., Henry, D. H., Redner, R.L., Rice, L., Schipperus, M.R., Guo, D.M. & Nichol, J.L. (2008) Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet, 37, 95–403. Severinsen, M.T., Engebjerg, M.C., Farkas, D.K., Jensen, A.Ø., Nørgaard, M., Zhao, S. & Sørensen, H.T. (2010) Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study. British Journal of Haematology, 152, 360–362. Stasi, R. (2011) Pathophysiology and therapeutic options in primary immune thrombocytopenia. Blood Transfusion, 9, 262–273. Tagariello, G., Sartori, R., Radossi, P., Maschio, N., Risato, R. & Stasi, R. (2011) Romiplostim for the early management of severe immune thrombocytopenia unresponsive to conventional treatment. British Journal of Haematology. Doi: 10.1111/j.1365-2141.2011.08950.x. [Epub ahead of print].
British Journal of Haematology | 2018
Hideaki Nitta; Akihiko Gotoh; Masaru Tanaka; Yasunobu Sekiguchi; Yasunori Ota; Masaaki Noguchi; Norio Komatsu
Baumann, U., Fern andez-S aiz, V., Rudelius, M., Lemeer, S., Rad, R., Knorn, A.M., Slawska, J., Engel, K., Jeremias, I., Li, Z., Tomiatti, V., Illert, A.L., Targosz, B.S., Braun, M., Perner, S., Leitges, M., Klapper, W., Dreyling, M., Miething, C., Lenz, G., Rosenwald, A., Peschel, C., Keller, U., Kuster, B. & Bassermann, F. (2014) Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis. Nature Medicine, 20, 1401–1409. Fadeel, B. & Grzybowska, E. (2009) HAX-1: a multifunctional protein with emerging roles in human disease. Biochimica et Biophysica Acta, 1790, 1139–1148. Han, J., Goldstein, L.A., Hou, W., Froelich, C.J., Watkins, S.C. & Rabinowich, H. (2010) Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. Journal of Biological Chemistry, 285, 22461–22472. Jitkaew, S., Trebinska, A., Grzybowska, E., Carlsson, G., Nordstr€ om, A., Lehti€ o, J., Fr€ ojmark, A.S., Dahl, N. & Fadeel, B. (2009) N-tosyl-Lphenylalanine chloromethyl ketone induces caspase-dependent apoptosis in transformed human B cell lines with transcriptional downregulation of anti-apoptotic HS1-associated protein X-1. Journal of Biological Chemistry, 284, 27827–27837. Kilpinen, S., Autio, R., Ojala, K., Iljin, K., Bucher, E., Sara, H., Pisto, T., Saarela, M., Skotheim, R.I., Bj€ orkman, M., Mpindi, J.P., Haapa-Paananen, S., Vainio, P., Edgren, H., Wolf, M., Astola, J., Nees, M., Hautaniemi, S. & Kallioniemi, O. (2008) Systematic bioinformatic analysis of expression levels of 17,330 human genes across 9,783 samples from 175 types of healthy and pathological tissues. Genome Biology, 9, R139. Klein, C., Grudzien, M., Appaswamy, G., Germeshausen, M., Sandrock, I., Sch€affer, A.A., Rathinam, C., Boztug, K., Schwinzer, B., Rezaei, N., Bohn, G., Melin, M., Carlsson, G., Fadeel, B., Dahl, N., Palmblad, J., Henter, J.I., Zeidler, C., Grimbacher, B. & Welte, K. (2007) HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). Nature Genetics, 39, 86–92. Kwiecinska, A., Ottosson-Wadlund, A., Ceder, R., Grafstr€ om, R.C., Bj€ orck, E., Nordenskj€ old, M., Porwit, A. & Fadeel, B. (2011) HAX-1 expression in human B lymphoma. Leukemia, 25, 868–872. Peckl-Schmid, D., Wolkerstorfer, S., K€ onigsberger, S., Achatz-Straussberger, G., Feichtner, S., Schwaiger, E., Zaborsky, N., Huemer, M., Gratz, I.K., Schibli, R., Lamers, M., Crameri, R., Moser, K., Luger, E.O. & Achatz, G. (2010) HAX1 deficiency: impact on lymphopoiesis and B-cell development. European Journal of Immunology, 40, 3161–3172. Rajkumar, S.V., Dimopoulos, M.A., Palumbo, A., Blade, J., Merlini, G., Mateos, M.V., Kumar, S., Hillengass, J., Kastritis, E., Richardson, P., Landgren, O., Paiva, B., Dispenzieri, A., Weiss, B., LeLeu, X., Zweegman, S., Lonial, S., Rosinol, L., Zamagni, E., Jagannath, S., Sezer, O., Kristinsson, S.Y., Caers, J., Usmani, S.Z., Lahuerta, J.J., Johnsen, H.E., Beksac, M., Cavo, M., Goldschmidt, H., Terpos, E., Kyle, R.A., Anderson, K.C., Durie, B.G. & Miguel, J.F. (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. The Lancet Oncology, 15, e538–e548. Ramsay, A.G., Keppler, M.D., Jazayeri, M., Thomas, G.J., Parsons, M., Violette, S., Weinreb, P., Hart, I.R. & Marshall, J.F. (2007) HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin avb6. Cancer Research, 67, 5275–5284.
Journal of Clinical Oncology | 2016
Masahiro Yokoyama; Yoshiharu Kusano; Anna Takahashi; Norihito Inoue; Tadahiro Gunji; Hideaki Nitta; Kyoko Ueda; Noriko Nishimura; Yuko Mishima; Yasuhito Terui; Kiyohiko Hatake
e21605Background: Cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP) is standard therapy for patients (pts) with CD20 positive non-Hodgkin lymphomas (CD20+NHLs). America...
Internal Medicine | 2011
Hideaki Nitta; Yuka Harada; Yoshiko Okikawa; Masayoshi Fujii; Koji Arihiro; Akiro Kimura; Hironori Harada
Blood | 2017
Hideaki Nitta; Akihiko Gotoh; Masaru Tanaka; Tomonori Ochiai; Yasunori Ota; Norio Komatsu
Annals of Oncology | 2016
Yoshiharu Kusano; Yasuhito Terui; Masahiro Yokoyama; Noriko Nishimura; Yuko Mishima; Kyoko Ueda; Hideaki Nitta; Tadahiro Gunji; Norihito Inoue; Anna Takahashi; Kiyohiko Hatake
Annals of Oncology | 2014
Aya Ouchi; Masahiro Yokoyama; Kengo Takeuchi; Yoshiharu Kusano; Hideaki Nitta; Kyoko Ueda; Noriko Nishimura; Naoko Tsuyama; Yasuhito Terui; Kiyohiko Hatake
Annals of Oncology | 2013
Noriko Nishimura; Yasuhito Terui; Aya Ouchi; Kyoko Ueda; Hideaki Nitta; Masahiro Yokoyama; Naoko Tsuyama; Kengo Takeuchi; Kiyohiko Hatake