Hideharu Matsubara

Experimental Study on Meniere's Disease

Experimental hydrops caused by underabsorption of endolymphatic fluid is a model of remissional stage of Menieres disease. In this study, another type of model, ie, hydrops caused by overproduction of endolymphatic fluid, was accomplished by applying various pressures into scala media through a micropipette via stria vascularis. This type of hydrops could be a model of attacks of Menieres disease. By using two types of the model, effects of glycerol administration and of opening the endolymphatic sac were discussed.

Bilateral Meniere’s Disease

A survey of 265 Japanese patients with Menieres disease revealed bilateral involvement in approximately 29% of all these patients. Somatic and psychiatric aspects of bilateral Menieres disease were as follows. (1) The duration of the disease in cases of bilateral involvement was significantly longer than cases of unilateral involvement. (2) An abnormal general condition, a more extensive degree of hearing loss and neurotic type were frequently diagnosed in cases of bilateral involvement. Based on these results, it was concluded that psychiatric management and prevention of aggravation of deafness should be part of the management of treatment in bilateral Menieres disease.

Treatment of Ménière’s Disease with Isosorbide

The effects of isosorbide – a dehydric alcohol formed by the abstraction of two molecules of water from one of sorbitol – on Meniere’s disease were examined, first using a model and then clinically. (

Clinical Factors Relating to the Positive Glycerol Test for Ménière’s Disease

In order to investigate the clinical factors relating to positive glycerol tests, 51 patients with Ménières disease were subjected to a complete battery of audiometric examinations, including the short increment sensitivity index, Bekesy, alternate binaural loudness balance, speech discrimination and pure-tone audiometry tests, both before and after glycerol ingestion. The correlation between positive glycerol tests and vestibular response, cochlear symptoms, age at onset and disease duration was investigated. High ratios of positive tests were obtained in the following categories of patients with Ménières disease: elderly patients with vertiginous attacks; patients with high-level hearing loss; nystagmus patients, and patients with fluctuating hearing loss.

Righting Reflex of the Head and Body

頭部の立ち直り反射と, 体の立ち直り反射の相互関係を検討する目的で, 頭部加速度と重心動揺を同時記録する装置を考案し, 検討した. その結果, 次の事がわかった.1) 開眼時の重心動揺に対し, 頭位は正頭位の事が多い.2) 閉眼時の重心動揺 (移行) に伴い, これに相当する重力の方向に対する頭部傾斜が認められる. しかし, 頭部傾斜は, 重心移動相当量以上のものではない.3) 重心の高い人, 低い人で, 一定量の重心移動に際し, 頭部傾斜に差は認めない.4) 前庭迷路障害例では, 得られる記録図のパターンは, 正常者のそれと全く異なる.

A Multi-channel Telemetric System for the ENT-Ward

The analysis of physiological data on patients in the ward is essential for the study of their normal and pathological basis. Linked by cable to recording device, the patients are very limited in their movements. The telemetry method permits the study of the subject in real time and recording from unrestrained, behaving patients.Features of the telemetry system in our ENT-ward were described with some typical examples of the use. This technique, easy to use at night, offers a considerable progress in otolaryngologic clinic and research.