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Hidehiko Okazawa

Tohoku University

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Annals of Nuclear Medicine | 1995

Clinical application of62Zn/62Cu positron generator: Perfusion and plasma pool images in normal subjects

Hidehiko Okazawa; Yasuhisa Fujibayashi; Yoshiharu Yonekura; Nagara Tamaki; Sadahiko Nishizawa; Yasuhiro Magata; Koichi Ishizu; Tatsuro Tsuchida; Norihiro Sadato; Junji Konishi; Akira Yokoyama; Ren Iwata; Tatsuo Ido

We have developed a new62Zn/62Cu positron generator, and applied it for PET imaging of perfusion and plasma volume in 5 normal subjects. The generator makes it possible by a simple procedure to obtain62Cu eluate and labeling compounds sufficiently every 40–60 minutes.62Cu labeled pyruvaldehyde bis(N4-methylthiosemicarbazone) copper II (62Cu-PTSM) was employed for cerebral and my ocardial perfusion imaging and62Cu labeled human serum albumin-dithiosemicarbazone (62Cu-HSA-DTS) was used for plasma pool imaging. The images of cerebral blood flow, cerebral plasma volume and myocardial perfusion were excellent. In addition, the analysis of tissue activity and blood activity demonstrated the microspheric character of62Cu-PTSM. Correction of arterial activity with the standard disappearance curve of62Cu-PTSM suggested the possibility of quantifying blood flow. The results of this study indicate the capability of the62Zn/62Cu generator for wide clinical use without an in-house cyclotron.

Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Development of an automatic Copper-62 ATSM preparation module in aseptic condition

Tetsuya Mori; Kenji Takaki; Yasushi Kiyono; Yasuhisa Fujibayashi; Hidehiko Okazawa

Society of Nuclear Medicine Annual Meeting Abstracts | 2012

Evaluation of radiobromine-labeled (2S,{alpha}S)-2-({alpha}-(2-bromophenoxy)benzyl)morpholine as an imaging probe for brain norepinephrine transporter

Yasushi Kiyono; Tetsuya Mori; Tatsuya Asai; Yasuhisa Fujibayashi; Hidehiko Okazawa

Society of Nuclear Medicine Annual Meeting Abstracts | 2011

A novel application of radiolabeled Cu-ATSM as an indicator of intercellular over-reduced states in disorders with mitochondrial dysfunction: Studies with cybrids carrying mitochondrial DNA mutation from MELAS patients

Yukie Yoshii; Makoto Yoneda; Masamichi Ikawa; Takako Furukawa; Yasushi Kiyono; Tetsuya Mori; Hiroshi Yoshii; Nobuyuki Oyama; Hidehiko Okazawa; Yasuhisa Fujibayashi

Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Different distribution of Cu-ATSM and FDG in head-and-neck cancers

Hidehiko Okazawa; Myungmi Oh; Takashi Kudo; Yasushi Kiyono; Tetsuya Mori; Masato Kobayashi; Yasuhisa Fujibayashi

Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Functional estrogen receptor {alpha} imaging PET with 16{alpha}-[18F]fluoro-17{beta}-estradiol in endometrial carcinoma

Tetsuya Tsujikawa; Yoshio Yoshida; Takashi Kudo; Tetsuji Kurokawa; Yasushi Kiyono; Yasuhisa Fujibayashi; Hidehiko Okazawa

Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Application of radioiodinated (2S,{alpha}S)-2-[{alpha}-(2-iodophenoxy)benzyl]morpholine to neuroendocrine tumor imaging.

Yasushi Kiyono; Ryuichi Nishii; Julius Balatoni; Yukie Yoshii; Masato Kobayashi; Yasuhiro Magata; Hidehiko Okazawa; Yasuhisa Fujibayashi; Juri Gelovani

Society of Nuclear Medicine Annual Meeting Abstracts | 2008

Effect of intravenous adenosine-tri-phosphate (ATP) on cerebral blood flow by bolus 15O-labeled water PET study on human volunteers

Raihan Hussain; Tatsuro Tsuchida; Takashi Kudo; Tsujikawa Tetsuya; Masato Kobayashi; Yasuhisa Fujibayashi; Hidehiko Okazawa

Society of Nuclear Medicine Annual Meeting Abstracts | 2008

Histological differentiation in lung cancer with 3-point imaging of FDG-PET

Tatsuro Tsuchida; Yoshiki Demura; Hidehiko Okazawa; Tetsuya Tsujikawa; Takashi Kudoh; Hirohiko Kimura

Society of Nuclear Medicine Annual Meeting Abstracts | 2008

Emission segmented attenuation correction method without transmission scan can accurately measure tissue tracer concentration on small animal PET

Masato Kobayashi; Takashi Kudo; Yasushi Kiyono; Tetsuya Tsujikawa; Mitsuo Watanabe; Hidehiko Okazawa; Yasuhisa Fujibayashi

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Yasuhisa Fujibayashi

Washington University in St. Louis

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Yasushi Kiyono

University of Fukui

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Tetsuya Mori

University of Fukui

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Takashi Kudo

Kyoto University

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Masato Kobayashi

Waseda University

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Tatsuro Tsuchida

University of Fukui

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Tetsuya Tsujikawa

University of Fukui

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Takako Furukawa

Kansai Medical University

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Yasuhiro Magata

Hamamatsu University

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Yukie Yoshii

National Institute of Radiological Sciences

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