Hidetoshi Satoh

P-126 Diagnosis of Cardiac Amyloidosis with Quantitative Analysis of Myocardial Technetium-99m-Pyrophosphate Scintigraphy

Objective: To determine the correlation of Duke treadmill score with gated SPECT-MPI in patients evaluated for chest pain. Methods: We conducted a retrospective study on 200 consecutive patients referred to our imaging laboratory for evaluation of chest pain by using stress MPI from January to August 2008. DTS was calculated after exercise testing and categorized as low, moderate and high subgroups. Subsequent gated SPECT-MPI was performed and stratified according to severity of perfusion defect. Spearmans rho was applied to determine the correlation. Results: The overall result shows positive linear correlation between DTS and MPI (p 0.001). Out of 200 patients, 136 (68%) had low DTS, 51 (25.5%) had moderate and 13 (6.5%) had high DTS respectively. In low DTS group 129 (95%) patients had low risk MPI and 7 (5%) had intermediate risk MPI. In moderate risk DTS group 25 (49%) had low risk MPI whereas 15 (29.5%) and 11 (21.5%) had intermediate and high risk MPI respectively. In high DTS group all 13 patients had high risk MPI. Conclusion: On the basis of our findings it can be hypothesized that patients with high DTS can be referred for coronary angiography without imaging and patients with low DTS can be followed on medical management. However for definite conclusion diagnostic accuracy need to be determine in further studies.