Hiroji Ina

A total synthesis of (+)-Castanospermine

Abstract A stereoselective total synthesis of (+)-castanospermine has been achieved via non-carbohydrate approach utilizing a chiral allylic alcohol as a versatile building block.

The chiral total synthesis of (–)-oncinotine

The first chiral synthesis of (–)-oncinotine 1 in natural form has been achieved starting from the protected (S)-N-benzyloxycarbonyl-2-piperidylacetaldehyde 3 based on a new route involving 17-membered ring formation via iminium cyclization, which establishes the 17R absolute configuration of natural 1.