Hirokatsu Nagura
Tokyo Institute of Technology
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Featured researches published by Hirokatsu Nagura.
Bioscience, Biotechnology, and Biochemistry | 2004
Noritaka Iwai; Takuma Ebata; Hirokatsu Nagura; Tomoya Kitazume; Kazuo Nagai; Masaaki Wachi
We have previously reported that a novel S-benzylisothiourea derivative, S-(3,4-dichlorobenzyl)isothiourea, tentatively named A22, induced spherical cells in Escherichia coli. To elucidate the structural element(s) required for inducing these spherical cells, the biological activity of S-benzylisothiourea derivatives and related compounds toward E. coli cells was investigated. S-(4-Chlorobenzyl)isothiourea revealed spherical cell-inducing activity, although being slightly less potent than A22, and S-benzylisothiourea itself showed much less activity. S-Cyclohexylmethylisothiourea did not show antibacterial activity and had little effect on the cell shape. S-Heptylisothiourea showed antibacterial activity and induced elongated cells rather than spherical cells. Benzylisothiocyanate inhibited cell growth but did not induce spherical cells. S-Ethylisothiourea, benzylthiocyanate, benzylisocyanate, and N-phenylthiourea did not show any activity under the present experimental conditions. These results indicate that the S-benzylisothiourea structure was necessary and sufficient for inducing spherical cells and that 3- and/or 4-chloro-substitution of the S-benzyl group enhanced this activity.
Bioscience, Biotechnology, and Biochemistry | 2007
Noritaka Iwai; Takuya Fujii; Hirokatsu Nagura; Masaaki Wachi; Tomoya Kitazume
We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.
Tetrahedron | 2007
Hirokatsu Nagura; Satoru Murakami; Toshio Fuchigami
Tetrahedron | 2009
Hirokatsu Nagura; Shinsuke Inagi; Toshio Fuchigami
Tetrahedron | 2010
Hirokatsu Nagura; Shunsuke Kuribayashi; Yutaka Ishiguro; Shinsuke Inagi; Toshio Fuchigami
Journal of Fluorine Chemistry | 2007
Bakenova Zagipa; Hirokatsu Nagura; Toshio Fuchigami
Chemical Communications | 2008
Yuichiro Kishi; Hirokatsu Nagura; Shinsuke Inagi; Toshio Fuchigami
Journal of Fluorine Chemistry | 2004
Tomoya Kitazume; Hirokatsu Nagura; Shinichi Koguchi
Synlett | 2008
Hirokatsu Nagura; Toshio Fuchigami
Synlett | 2007
Asami Hidaka; Bakenova Zagipa; Hirokatsu Nagura; Toshio Fuchigami