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Dive into the research topics where Hirokatsu Nagura is active.

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Featured researches published by Hirokatsu Nagura.


Bioscience, Biotechnology, and Biochemistry | 2004

Structure-Activity Relationship of S-Benzylisothiourea Derivatives to Induce Spherical Cells in Escherichia coli

Noritaka Iwai; Takuma Ebata; Hirokatsu Nagura; Tomoya Kitazume; Kazuo Nagai; Masaaki Wachi

We have previously reported that a novel S-benzylisothiourea derivative, S-(3,4-dichlorobenzyl)isothiourea, tentatively named A22, induced spherical cells in Escherichia coli. To elucidate the structural element(s) required for inducing these spherical cells, the biological activity of S-benzylisothiourea derivatives and related compounds toward E. coli cells was investigated. S-(4-Chlorobenzyl)isothiourea revealed spherical cell-inducing activity, although being slightly less potent than A22, and S-benzylisothiourea itself showed much less activity. S-Cyclohexylmethylisothiourea did not show antibacterial activity and had little effect on the cell shape. S-Heptylisothiourea showed antibacterial activity and induced elongated cells rather than spherical cells. Benzylisothiocyanate inhibited cell growth but did not induce spherical cells. S-Ethylisothiourea, benzylthiocyanate, benzylisocyanate, and N-phenylthiourea did not show any activity under the present experimental conditions. These results indicate that the S-benzylisothiourea structure was necessary and sufficient for inducing spherical cells and that 3- and/or 4-chloro-substitution of the S-benzyl group enhanced this activity.


Bioscience, Biotechnology, and Biochemistry | 2007

Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

Noritaka Iwai; Takuya Fujii; Hirokatsu Nagura; Masaaki Wachi; Tomoya Kitazume

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.


Tetrahedron | 2007

Photochemical generation of difluoromethyl radicals having various functional groups and their highly regioselective addition to olefins and aromatic substitution

Hirokatsu Nagura; Satoru Murakami; Toshio Fuchigami


Tetrahedron | 2009

Electrochemical fluoro-selenenylation of electron-deficient olefins

Hirokatsu Nagura; Shinsuke Inagi; Toshio Fuchigami


Tetrahedron | 2010

Electrochemical iodofluorination of electron-deficient olefins

Hirokatsu Nagura; Shunsuke Kuribayashi; Yutaka Ishiguro; Shinsuke Inagi; Toshio Fuchigami


Journal of Fluorine Chemistry | 2007

Electrolytic partial fluorination of organic compounds: 89: Regioselective anodic fluorination of tetrazolyl sulfides

Bakenova Zagipa; Hirokatsu Nagura; Toshio Fuchigami


Chemical Communications | 2008

Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts.

Yuichiro Kishi; Hirokatsu Nagura; Shinsuke Inagi; Toshio Fuchigami


Journal of Fluorine Chemistry | 2004

One step synthesis of 2-substituted 3-tri-(or di-)fluoromethyl-2-propenals in an ionic liquid

Tomoya Kitazume; Hirokatsu Nagura; Shinichi Koguchi


Synlett | 2008

Regioselective Electrochemical Monofluorination of α-Sulfonyl Sulfides

Hirokatsu Nagura; Toshio Fuchigami


Synlett | 2007

Regioselective Anodic Fluorination of α-(Arylthio)benzylphosphonate Esters, α-(Arylthio)methylphosphonate Esters and Their Analogues

Asami Hidaka; Bakenova Zagipa; Hirokatsu Nagura; Toshio Fuchigami

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Toshio Fuchigami

Tokyo Institute of Technology

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Shinsuke Inagi

Tokyo Institute of Technology

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Tomoya Kitazume

Tokyo Institute of Technology

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Bakenova Zagipa

Tokyo Institute of Technology

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Masaaki Wachi

Tokyo Institute of Technology

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Noritaka Iwai

Tokyo Institute of Technology

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Shunsuke Kuribayashi

Tokyo Institute of Technology

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Asami Hidaka

Tokyo Institute of Technology

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Satoru Murakami

Tokyo Institute of Technology

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