Tomoya Kitazume

Synthesis of fluorinated materials catalyzed by proline or antibody 38C2 in ionic liquid

Abstract The utility of reusable ionic liquid–proline (or aldolase antibody 38C2) reaction system, proceeding the aldol reactions, is described. Further, obtained α-chloro-β-hydroxy compounds were transformed to the optically active α,β-epoxy carbonyl compounds. The aldolase antibody 38C2–ionic liquid system was able to reuse in Michael additions and the reaction of fluoromethylated imines.

Structure-Activity Relationship Study of the Bacterial Actin-Like Protein MreB Inhibitors: Effects of Substitution of Benzyl Group in S-Benzylisothiourea

We comprehensively investigated the effects of substitution of the benzyl group in S-benzylisothiourea derivatives on antibacterial activity, because we found previously that some substitutions enhanced it. A 2,4-Cl2-derivative was found to be the most effective compound, it was stronger than the original one in Gram-negative rod shaped-bacteria such as Escherichia coli and Salmonella typhimurium.

Synthesis of fluoromethylated materials in ionic liquids

Abstract Syntheses of fluoromethylated materials via Michael additions with the Baylis–Hillman type reaction and the reaction of fluoromethylated imines with enamines in ionic liquid are described.

Synthesis and antibacterial activity of alaremycin derivatives for the porphobilinogen synthase

The preparation and the antibacterial activity of alaremycin derivatives such as their CF(3)-derivatives and (R)- and (S)-4-oxo-5-acetylaminohexanoic acid for the porphobilinogen synthase (PBGS), were described. The IC(50) values of the antibacterial activity of the prepared materials for the inhibitor of PBGS, were determined using PBGS assay.