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Hiromi Baba

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Publication

Featured researches published by Hiromi Baba.

Bioorganic & Medicinal Chemistry Letters | 1993

4,5,6,7-Tetrahdryo-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiiotensin II receptor antagonists

Takashi Yanagisawa; Naoto Ueyama; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Seiichiro Mochizuki; Kazukiro Kozakai; Tsuyoshi Tomiyama

Abstract 1,4,5,6,7,8-hexahydrocycloheptimidazoles and 4,5,6,7-tetrahydro-8-oxo-cycloheptimidazolones were synthesized as potential angiotensin-II (AII) receptor antagonists. One of these, 11c, KT3-671, was more potent than losartan with a pA2 value of 10.04 and At1 specific with an IC50 of 0.8 nM. In an in vivo study, it had long lasting action on blood pressure in RHR rat at a dose of 3 mg/kg.

Chemical & Pharmaceutical Bulletin | 1994

Nonpeptide Angiotensin II Receptor Antagonists. I. Synthesis and Biological Activity of Pyridine Derivatives

Naoto Ueyama; Takashi Yanagisawa; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Seiichiro Mochizuki; Kazuhiro Kosakai; Tsuyoshi Tomiyama

Archive | 1993

Cycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Makoto Haketa

Archive | 1994

Carboxymethylidenecycloheptimidazole derivatives, method of manufacturing the same and therapeutic agents containing these compounds

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Hiromi Baba

Archive | 1994

Carboximetilidencicloheptimidazol derivatives and method for preparing them.

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Hiromi Baba

Archive | 1994

Dérivés du carboxyméthylidènecycloheptimidazole, méthode pour leur fabrication et agents thérapeutiques les contenant.

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Hiromi Baba

Archive | 1994

Derivados de carboximetilidencicloheptimidazol y metodo para prepararlos.

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Hiromi Baba

Archive | 1994

Neue Carboxymethylidencycloheptimidazol-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als antihypertensive und anticongestive Mittel New Carboxymethylidencycloheptimidazol derivatives, processes for their preparation and their use as antihypertensive agents and anticongestive

Hiromi Baba; Akira Tomiyama; Tsuyoshi Tomiyama; Naoto Ueyama; Takashi Yanagisawa

Archive | 1994

New Carboxymethylidencycloheptimidazol derivatives, processes for their preparation and their use as antihypertensive agents and anticongestive

Hiromi Baba; Akira Tomiyama; Tsuyoshi Tomiyama; Naoto Ueyama; Takashi Yanagisawa

Archive | 1993

Dérivés de cycloheptimidazole, procédé pour les préparer et composition pharmaceutique et agents thérapeutiques les contenant.

Tsuyoshi Tomiyama; Akira Tomiyama; Takashi Yanagisawa; Naoto Ueyama; Tomoyuki Kawai; Motoharu Sonegawa; Hiromi Baba; Makoto Haketa

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Collaboration

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Takashi Yanagisawa

National Institute of Radiological Sciences

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Tsuyoshi Tomiyama

Tohoku University

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Naoto Ueyama

Hokuriku University

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Tomoyuki Kawai

Hokuriku University

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Motoharu Sonegawa

Astellas Pharma

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Kazuhiro Kosakai

Tohoku University

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