Hiroshi Mitsui

Absorption of various drugs through the rabbit's respiratory mucosa in vitro

ZusammenfassungDie Aufnahme von DOTC, AKM, CEZ, PC-G, Predonisolon und menschlichem IgG durch die Trachealmucosa des Kaninchens wurde mit der Doppelkammermethode geprüft. Als Resultat zeigte sich, daß die Trachealmucosa sowohl kleine Moleküle als auch Makromoleküle resorbieren konnte. Durch die Interzeüularspalten wurde DOTC, ein kleines Molekül von dem Trachealepithelium durch Diffusion resorbiert. Das menschliche IgG, ein Makromolekül, wurde durch den Mechanismus des Energie verbrauchenden Transportprozesses resorbiert. Die vorliegende Studie läßt neue Wege für die Verwendung einer intrarespiratorischen Verabreichung von Arzneien erkennen und kann wichtigen Erkenntnissen über den Mechanismus der respiratorischen Allergie führen.SummaryThe absorption of doxycycline (DOTC), bekanamycin (AKM), cefazolin (CEZ), penicillin G (PC-G), predonisolone, and human IgG through the rabbits tracheal mucosa was examined using the double-chamber method. The results indicate that the tracheal mucosa can absorb both small molecules and macromolecules. Passing through the intercellular space, DOTC, a small molecule, was absorbed through the tracheal epithelium by diffusion. Human IgG, a macromolecule, was absorbed by the mechanism of an energy-consuming transport process. This study of the absorption of drugs through the respiratory mucosa could open up new areas in the utilization of intrarespiratory administration of drugs and lead to a better understanding of the mechanisms involved in respiratory allergies.

Application of Mucodyne to Chronic Sinusitis.

The therapeutic effect of S-carboxymethyl cystein (S-CMC, Mucodyne®) was examined in 54 patients with chronic sinusitis. A dose of 1500mg/day of S-CMC was administered to the patients for 4 weeks, and its effectiveness was evaluated at the end of treatment.1) The overall efficacy rate was 78.7% and the efficacy rate for good responses was 46.8%.2) An adverse reaction was noted in only one patient (1.9%).

A Clinical Examination of Malignant Tumor of the Palatine Tonsil

From 1961 to 1980, 45 patients with malignant tumor of the palatine tonsil were treated at the Department of Otolaryngology, Mie University Hospital. Of these, 12 patients were cancer and 33 sarcoma.Tonsillar cancer predominantly affected the male, whereas sarcoma was found in the male and female almost equally. The age distribution of tonsillar cancer was uniform, while there were two peaks in the fourth and seventh decades of life for tonsillar sarcoma. Eighty-three percent of cancer was squamous cell carcinoma, and all the sarcoma cases were malignant lymphoma of which 94% were reticulum cell sarcoma. Seventy-five percent of carcinoma were stage III or IV, while 94% of malignant lymphoma were stage I or II at the time of diagnosis. Sore throat was the most commonly encountered chief complaint for both carcinoma and malignant lymphoma. Three patients (25%) of those with carcinoma and four (12%) malignant lymphoma patients complained of a lump in the neck.All the patients with tonsillar malignancy underwent radiation therapy, and chemotherapy was also used in nine patients (75%) with carcinoma and 19 (58%) with malignant lymphoma. Crude survival rates for tonsillar cancer was 64% for 1 year, 20% for 2 years, 11% for 3 years and 0% for 5 years, and for malignant lymphoma of the palatine tonsil it was 45% for 1 year, 40% for 2 years, 37% for 3 years and 22% for 5 years.Although both carcinoma and malignant lymphoma had poor prognosis in this study, the preliminary results of combined radiation and chemotherapy for malignant lymphoma were encouraging. It was found that the total radiation dose of 5, 000-7, 000rads for carcinoma and 4, 000-6, 000rads for malignant lymphoma of the palatine tonsil was satisfactory in this study.

A Case of a Sewing Needle Foreign Body in the Pharyngeal Wall

A case of a pharyngeal foreign body was reported with a review of the literature. A 19-year-old woman voluntarily swallowed a sewing needle. Though the foreign body was invisible in the pharyngeal region, X-ray examination revealed a concealed needle in front of the second cervical vertebra. Under general anesthesia with tracheotomy, the patient was placed in the supine position, with the head excessively extended. The concealed needle in the suspected area which was surrounded by Ligaclips® on three points was confirmed by an image amplifier. The needle was removed from the posterior wall of the pharynx perorally. The psychiatrist pointed out that she was irritable and emotionally unstable.We analyzed 49 cases of foreign bodies in the pharynx and esophagus treated in the Department of Otolaryngology, Mie University Hospital during the period of 1975-1980, as well as 5 cases of concealed needles in these areas reported in the Japanese literature.