Hiroya Fujino

Ciliated hepatic foregut cyst: A report of one case and a review of the literature

We encountered a patient with a ciliated hepatic foregut cyst (CHFC), which is an uncommon cystic lesion of the liver and hard to distinguish from malignant tumor in imaging features. Cases of CHFC are very rare, five cases were reported in the 19th century and 53 cases in the 20th century. The histogenesis of CHFC is still unclear, but most authors consider that it could arise from the embryonic foregut. A few cases of CHFC mimicking neoplasm were reported. When the diagnosis of CHFC was obtained by fine needle aspiration, close follow-up is necessary in order to find early malignant change.

Healing Process of Experimental Esophageal Ulcers Induced by Acetic Acid in Rats

We studied the healing of acetic acid-induced esophageal ulcers in rats with respect to the cellular kinetics. Esophageal ulcers were induced by topical application of acetic acid to the serosal surface. Well-demarcated circular or elliptical ulcers had developed by day 3 after the acid treatment. These ulcers began to decrease in size from day 7 and had healed by day 14. Histological and cellular kinetic findings, with bromodeoxyuridine (BrdU), were degeneration of the esophageal mucosa on day 1 and ulcer formation on day 3, with an increase in the number of BrdU-labeled cells in the esophageal mucosa around the ulcer. On day 7, regenerated epithelium was found to extend towards the ulcer base and the regenerated epithelium had become thicker, with papilla formation, by day 10. On day 14, the ulcer base was covered with thickened regenerated mucosa, with a decrease in the number of BrdU-labeled cells. Marked proliferative activity of the regenerated mucosa and thickening of the esophageal mucosa, with papilla formation, were observed during the healing process.

Six cases of cytomegalovirus hepatitis in healthy adults.

本邦では比較的稀な健常成人に発症したサイトメガロウイルス(CMV)肝炎6症例を経験したので,それらの臨床病理学的特徴につき検討し,さらにEBウイルス(EBV)肝炎と比較検討した.CMV肝炎発症患者は,若年男性に多く,発症時期は夏から秋に多かった.CMV肝炎の臨床像は,発熱等の感冒様症状,肝脾腫がしばしばみられ,血清トランスアミナーゼの上昇は軽度であった.CMV肝炎とEBV肝炎の比較では,CMV肝炎発症年齢はEBV肝炎発症年齢に比べて有意に高齢であった.血清GPT値はCMV肝炎の方が,EBV肝炎に比べて有意に低値であった.CMV肝炎2症例の肝組織像では,核内封入体はみられず,門脈域及び類洞内への単核球の浸潤,肝細胞壊死,胆管障害の所見を認めた.