Hiroyuki Chiba | Researchain

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Featured researches published by Hiroyuki Chiba.

Organic Letters | 2015

Novel and Efficient Chromium(II)-Mediated Desulfonylation of α-Sulfonyl Ketone

Kazato Inanaga; Takashi Fukuyama; Manabu Kubota; Yuki Komatsu; Hiroyuki Chiba; Akio Kayano; Katsuya Tagami

A novel and efficient method for the Cr(II)-mediated desulfonylation of α-sulfonyl ketone by a Cr-ligand-Mn system has been developed during the course of process research on Halaven (eribulin mesylate). This reaction is dramatically accelerated in the presence of an appropriate bipyridyl-type ligand. This system is applicable to reduction of α-sulfur-substituted ketones. In addition, a Cr-Cp2ZrCl2-Mn catalytic system is also applicable to desulfonylation of α-sulfonyl ketone.

Synlett | 2013

Commercial Manufacture of Halaven®: Chemoselective Transformations En Route to Structurally Complex Macrocyclic Ketones

Brian Austad; Trevor L. Calkins; Charles E. Chase; Francis G. Fang; Thomas E. Horstmann; Yongbo Hu; Bryan M. Lewis; Xiang Niu; Thomas A. Noland; John D. Orr; Matthew J. Schnaderbeck; Huiming Zhang; Naoki Asakawa; Naoki Asai; Hiroyuki Chiba; Takashi Hasebe; Yorihisa Hoshino; Hiroyuki Ishizuka; Takashi Kajima; Akio Kayano; Yuki Komatsu; Manabu Kubota; Hirofumi Kuroda; Mamoru Miyazawa; Katsuya Tagami; Tomohiro Watanabe

Organic Process Research & Development | 2016

Application of Continuous Flow for DIBAL-H Reduction and n-BuLi Mediated Coupling Reaction in the Synthesis of Eribulin Mesylate

Takashi Fukuyama; Hiroyuki Chiba; Hirofumi Kuroda; Teiji Takigawa; Akio Kayano; Katsuya Tagami

Organic Process Research & Development | 2016

Application of a Rotor–Stator High-Shear System for Cr/Mn-Mediated Reactions in Eribulin Mesylate Synthesis

Takashi Fukuyama; Hiroyuki Chiba; Teiji Takigawa; Yuki Komatsu; Akio Kayano; Katsuya Tagami

Archive | 2000

Carbapenem compound crystals and interjection preparations

Hiroyuki Chiba; Masahiko Tsujii; Astsushi Koiwa; Shin Sakurai; Akio Kayano; Hiroyuki Ishizuka; Hiroyuki Saito; Taiju Nakamura; Ikuo Kushida; Yasuyuki Suzuki; Takako Yoshiba; Kazuhide Ashizawa; Masahiro Sakurai; Eiichi Yamamoto

Archive | 2012

Microreactor process for halichondrin b analog synthesis

Hiroyuki Chiba; Takashi Fukuyama; Yuki Komatsu; Teiji Takigawa

Archive | 2006

Crystals of 5-[2-amino-4-(2-furyl) pyrimidin-5-yl]-1-methylpyridin-2(1H)-one and processes for preparing the same

Hitoshi Harada; Hiroshi Ishihara; Yoshiaki Sato; Hiroyuki Chiba; Teiji Takigawa

Archive | 2000

CRYSTALS OF CARBAPENEM DERIVATIVES AND PHARMACEUTICAL PREPARATIONS FOR INJECTION

Hiroyuki Chiba; Masahiko Tsujii; Atsushi Koiwa; Shin Sakurai; Akio Kayano; Hiroyuki Ishizuka; Hiroyuki Saito; Taiju Nakamura; Ikuo Kushida; Yasuyuki Suzuki; Takako Yoshiba; Kazuhide Ashizawa; Masahiro Sakurai; Eiichi Yamamoto

Archive | 2000