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Archives of Toxicology | 1987

Recovery process of tracheal mucosa of guinea pigs exposed to isopropyl alcohol

Yoshihiro Ohashi; Yoshiaki Nakai; Hiroshi Ikeoka; Hiroyuki Koshimo; Yusuke Esaki; Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko

The toxicity of isopropyl alcohol (IPA) on the tracheal mucosa was studied experimentally with special reference to the recovery process of the organ. The results showed that 400 ppm IPA has an acute effect on the mucociliary system in the tracheal mucosa, and that recovery from such degeneration can occur in 2 weeks. When functional and morphological damage was induced by a higher level (5500 ppm) of IPA, recovery did not occur in 2 weeks. The conclusion is that the present allowable level of IPA is reasonable from the viewpoint of the effects of short-term exposure to IPA on the tracheal mucosa. In addition, a higher level of IPA exposure has longer-term effects on the tracheal mucosa, and workers exposed to such a higher level of IPA vapor should be given careful otolaryngological follow-up observations.


Environmental Research | 1988

Toxicity of isopropyl alcohol exposure on the nasal mucociliary system in the guinea pig

Yoshihiro Ohashi; Yoshiaki Nakai; Hiroyuki Koshimo; Yusuke Esaki; Hiroshi Ikeoka; Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko

The toxicity of isopropyl alcohol (IPA) on the nasal mucosa in the guinea pig was experimentally studied, with special reference to the recovery process of the organ. The results showed that 400 ppm of IPA has an acute effect on the nasal mucosa and the recovery from such degeneration can occur in 2 weeks. When functional and morphological damages were induced by a higher level (5500 ppm) of IPA, it took over 2 weeks for complete recovery from such damage. The conclusion is that the present allowable level of IPA is reasonable from a viewpoint of the effect of short-term exposure to IPA on the nasal mucosa. In addition, a higher level of IPA exposure has a longer-term effect on the nasal mucociliary system in the guinea pig, and workers exposed to such a higher level of IPA should be given careful otolaryngological observation.


Journal of Applied Toxicology | 1987

Acute effects of isopropyl alcohol exposure on the middle ear mucosa

Yoshihiro Ohashi; Yoshiaki Nakai; Hiroshi Ikeoka; Hiroyuki Koshimo; Yusuke Esaki; Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko


Journal of Applied Toxicology | 1988

An experimental study on the respiratory toxicity of isopropyl alcohol

Yoshihiro Ohashi; Yoshiaki Nakai; Hiroshi Ikeoka; Hiroyuki Koshimo; Yusuke Esaki; Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko


Environmental Research | 1993

Comparison of the neurotoxicity of several chemicals estimated by the peripheral nerve conduction velocity in rats

Keiko Teramoto; Fumiko Wakitani; Shun'ichi Horiguchi; T. Jo; T. Yamamoto; Hiroshi Mitsutake; Hiroyuki Nakaseko


Journal of Urban Living and Health Association | 1991

Comparison of Acute Toxicity of Several Organic Solvents Estimated by the Values of LD50 and LC50

Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko; Fumiko Wakitani; Hidenori Tanaka


Japanese journal of industrial health | 1991

Toxicity of Isopropyl Alcohol(IPA). Part 2. Repeated Inhalation Exposures in Rats.

Hiroyuki Nakaseko; Keiko Teramoto; Shun'ichi Horiguchi; Fumiko Wakitani; Tadasi Yamamoto; Muneo Adachi; Hidenori Tanaka; Sin'ichiro Hozu


Journal of Urban Living and Health Association | 1990

The Significance of Basophilic Stippled Cell as an Index of Lead Exposure (2)

Shun'ichi Horiguchi; Katsuya Kurosawa; Ginji Endo; Ikuko Kiyota; Kozo Shinagawa; Keiko Teramoto; Fumiko Wakitani; Hiroyuki Nakaseko; Toshio Kawaraya


Journal of Urban Living and Health Association | 1985

Effects of Isopropyl Alcohol Exposure on the Respiratory Tract Mucosa in Guinea Pigs

Shun'ichi Horiguchi; Keiko Teramoto; Hiroyuki Nakaseko; Yoshiaki Nakai; Yoshihiro Ohashi; Hiroshi Ikeda; Hiroyuki Koshimo; Yusuke Esaki


Osaka city medical journal | 1983

Health Examination with Liver function - Tests of Lead Workers

Shun'ichi Horiguchi; Ikuko Kiyota; Keiko Teramoto; Mitsuru Kageyama; Fumio Tojo; Hiroyuki Nakaseko

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