Hiroyuki Ushio
Mitsubishi
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Publication
Featured researches published by Hiroyuki Ushio.
Pharmaceuticals | 2013
Hiroyuki Ushio; Seigo Ishibuchi; Koichi Oshita; Noriyasu Seki; Hirotoshi Kataoka; Kunio Sugahara; Kunitomo Adachi; Kenji Chiba
Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immunomodulator. Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys. Our results suggest that Y-320, an orally active inhibitor for IL-17 production, provides a useful therapy for RA.
Archive | 2000
Hiroyuki Ushio; Seigo Ishibuchi; Youichiro Naito; Naoki Sugiyama; Takafumi Kawaguchi; Kenji Chiba; Makio Ohtsuki; Yoichi Naka
Archive | 2001
Hiroyuki Ushio; Youichiro Naito; Naoki Sugiyama; Takafumi Kawaguchi; Makio Ohtsuki; Kenji Chiba
Archive | 1996
Takashi Futamura; Tsugio Ikebe; Junichi Maeda; Nobuhiro Sakurai; Hiroyuki Ushio; 隆史 二村; 順一 前田; 伸弘 櫻井; 次男 池部; 博之 牛尾
Archive | 1976
Masumi Atsukawa; Kazumi Kamei; Naoharu Shinoda; Hiroyuki Ushio
Archive | 1996
Hiroshi Tanaka; Takanobu Kuroita; Seigo Ishibuchi; Hiroyuki Ushio; Takashi Futamura; Yoshitaka Ohashi; Kazuhiro Yano
Archive | 2001
Kenji Chiba; Yukio Hoshino; Masahiko Kagoshima; Hirotoshi Kataoka; Yoichiro Naito; Koichi Oshita; Hiroyuki Ushio; 洋一郎 内藤; 健治 千葉; 浩一 尾下; 幸夫 星野; 裕敏 片岡; 博之 牛尾; 正彦 鹿子嶋
Archive | 1976
Masumi Atsukawa; Hiroyuki Ushio; Haruo Kuwabara; Kyoji Kubo
Letters in Drug Design & Discovery | 2008
Hiroyuki Ushio; Seigo Ishibuchi; Kunitomo Adachi; Kouichi Oshita; Kenji Chiba
Archive | 2002
Kenji Chiba; Seigou Ishibuchi; Takashi Kawaguchi; Yoichiro Naito; Yoichi Naka; Makio Otsuki; Naoki Sugiyama; Hiroyuki Ushio; 洋一 中; 洋一郎 内藤; 健治 千葉; 真希夫 大槻; 貴史 川口; 直樹 杉山; 博之 牛尾; 正剛 石渕