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Dive into the research topics where Hoda Y. Tomoum is active.

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Featured researches published by Hoda Y. Tomoum.


Epilepsia | 2004

Physical Growth and Endocrinal Disorders during Pubertal Maturation in Girls with Epilepsy

Hamed A. El-Khayat; Fatma Z. Abd El-Basset; Hoda Y. Tomoum; Saeid M. Tohamy; Amira A. Zaky; Mervat S. Mohamed; Suzan M. Hakky; Nancy S. El Barbary; Nermin M. Nassef

Summary:  Purpose: This study investigated the effect of epilepsy and/or antiepileptic drugs (AEDs) on the physical growth, pubertal development, and androgenic status of girls with epilepsy between ages 8 and 18 years.


Epilepsia | 2003

Physical and Hormonal Profile of Male Sexual Development in Epilepsy

Hamed A. El-Khayat; Hamed M. Shatla; Gihan K. H. Ali; Mohammad O. Abdulgani; Hoda Y. Tomoum; Hussein A. Attya

Summary:  Purpose: This study was designed to investigate the effect of epilepsy and antiepileptic drugs (AEDs) on both the physical and hormonal aspects of the sexual development of male patients with epilepsy.


Pediatric Neurology | 2010

Melatonin and Sleep-Related Problems in Children With Intractable Epilepsy

Hamed A. El-Khayat; Sahar M. A. Hassanein; Hoda Y. Tomoum; Iman A. Abd-Elhamid; Tarek Asaad; Amany El-Wakkad

Children with epilepsy have high rates of sleep problems. Melatonin has been advocated in treatment of sleep disorders, and its beneficial effect has been confirmed in insomnia. The aim of this study was to assess melatonin levels in children with intractable epilepsy and its relation to pattern of sleep and characteristics of seizure disorder, as well as the effect of melatonin therapy on those parameters. The study was conducted on 23 children with intractable epilepsy and 14 children with controlled seizures. Patients were evaluated by psychometric sleep assessment and assay of diurnal and nocturnal melatonin levels. Children with intractable epilepsy received oral melatonin before bedtime. They were reassessed after 3 months. Children with intractable epilepsy had higher scores for each category of sleep walking, forcible teeth grinding, and sleep apnea. At the end of therapeutic trial, patients with intractable epilepsy exhibited significant improvement in bedtime resistance, sleep duration, sleep latency, frequent nocturnal arousals, sleep walking, excessive daytime sleepiness, nocturnal enuresis, forcible teeth grinding, sleep apnea, and Epworth sleepiness scores. There was also significant reduction in seizure severity. Thus, use of melatonin in patients with intractable seizures was associated with improvement of both many sleep-related phenomena and the severity of seizures.


Clinical Nutrition | 2010

Anthropometry and body composition analysis in children with cerebral palsy

Hoda Y. Tomoum; Nagia B. Badawy; Nayera E. Hassan; Khadija M. Alian

BACKGROUND & AIMS This study was undertaken to describe anthropometry, body composition parameters and assess serum levels of leptin and other biochemical markers of the nutritional status in a sample of Egyptian children with cerebral palsy(CP). METHODS Anthropometric measurements (body weight, knee height, head, mid-upper arm, waist and hip circumferences, triceps and subscapular skin-fold thickness) were taken. Using the bioelectrical impedance technique, total body water(TBW), fat-free mass, fat mass, fat percentage and basal metabolic rate(BMR) were calculated. Serum levels of total proteins, albumin, ferritin and leptin were measured. Results were compared to that of healthy controls. RESULTS Patients had significantly lower anthropometric measurements than controls, except for mid-upper arm and hip circumferences, and subscapular skin-fold thickness which were not different in both groups. Fat mass, fat free mass, fat percentage, TBW and BMR were lower in the patients. Serum protein and leptin levels were not different in patients and controls, though other biochemical markers were reduced in the patients. Patients with more severe motor handicap had lower skin-fold thickness, fat percentage and serum ferritin than those with milder affection. CONCLUSION Parameters of growth, body composition analysis and nutritional status are significantly altered in CP patients especially those with severe motor handicap and oromotor dysfunction.


Epilepsia | 2008

Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy

Hamed A. El-Khayat; Nancy A. Soliman; Hoda Y. Tomoum; Maher A. Omran; Amany S. El-Wakad; Rania H. Shatla

Purpose: We aimed to evaluate the effect of epilepsy on the reproductive hormones levels among female patients, and to investigate the frequency of catamenial pattern of seizures.


Journal of Child Neurology | 2007

Plasma interleukin-1β levels in children with febrile seizures

Hoda Y. Tomoum; Nagya M. Badawy; Afaf Abdelaleem Mostafa; Manal Y. Harb

Proinflammatory and anti-inflammatory cytokines regulate the febrile response during infection. In this study, the role of cytokines in the pathogenesis of febrile seizures was investigated, through comparing levels of interleukin-1β in the peripheral blood of children with febrile seizures and in a matched control group of children with febrile illnesses without seizures. The study included 33 children with febrile seizures (mean ± SD, 29.94 ± 14.9 months) and 38 controls with comparable age, sex, and type of infection. A laboratory workup for the diagnosis of infection was performed, and interleukin-1β levels were assessed by enzyme-linked immunosorbent assay for the patients and the control groups immediately on arrival at the hospital. The plasma levels of interleukin-1β were comparable in the patients and the control group (mean ± SD, 7.321 ± 3.123 and 8.087 ± 4.8 pg/mL, respectively). Furthermore, there was no significant difference when comparing the plasma levels of interleukin-1β in patients with simple and complex types of febrile seizures. Plasma interleukin-1β levels did not show a significant correlation to either the duration of the last seizure, the number of the previous attacks of febrile convulsion, or the degree of temperature. However, interleukin-1β levels were negatively correlated to the duration from the last seizure attack (r = −.8). Thus, the results of the present study do not support the hypothesis that increased production of interleukin-1β is involved in the pathogenesis of febrile seizures in children.


European Journal of Paediatric Neurology | 2010

Growth hormone levels in children and adolescents with epilepsy.

Hamed A. El-Khayat; Gamal Samy Aly; Hoda Y. Tomoum; Rasha Mamdouh; Abdelmalik K. Al-Badani; Essam I. Mohamed

BACKGROUND Patients with epilepsy often complain of symptoms that may be caused by disturbances in their hormonal balance. Disturbances in physical growth has been previously described. The aim of this study was to evaluate the effect of epilepsy and/or anti-epileptic drugs on the physical growth of patients with idiopathic epilepsy, as well as on the growth hormone (GH) and insulin growth factor-1 (IGF-1) status in those patients. METHODS The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine. Anthropometric measurements [occipitofrontal circumference, weight, height, body mass index, span, and midarm circumference] were taken. Serum levels of GH before and after provocation with L-dopa and of IGF-1 were assessed. Results were compared to a matched control group. RESULTS The height measurements were reduced in patients with epilepsy compared to the controls group. Though weight values were not significantly different, the body mass indices of the patients were significantly higher than controls, especially in patients on valproate therapy. Basal GH levels showed no significantly variation between patients and controls. However, post provocation GH and IGF-1 levels were significantly lower in patients. The type of epilepsy, disease duration, and the degree of seizure control had no significant effect on the studied parameters. In conclusion, physical growth seems to be affected in patients with epilepsy. This may be due to hormonal imbalance as evident by reduced post provocation GH levels and IGF-1 levels in the included group of patients.


Journal of Child Neurology | 2008

Lipid profile, apolipoproteins A and B in children with epilepsy.

Hoda Y. Tomoum; Maha Mohammed Awadallah; Dina A. Fouad; A. Ali

In this study, lipid profile was assessed, and the intimal wall thickness of both carotid arteries in children with idiopathic epilepsy was measured. The study comprised 22 children with idiopathic epilepsy on either carbamazepine or valproate. A profile including triglycerides, total cholesterol, low-density and high-density lipoproteins cholesterol, apolipoproteins AI and B, and Duplex estimation of intimal wall thickness of carotid arteries were performed. Patients on carbamazepine showed increase in total cholesterol, low-density and high-density lipoproteins cholesterol, and decrease in apolipoprotein AI levels compared with controls. Levels of total cholesterol, low-density lipoproteins cholesterol, and apolipoprotein AI were reduced in patients receiving valproate compared with controls, whereas total cholesterol, high-density lipoproteins cholesterol, and apolipoprotein AI were reduced compared with those receiving carbamazepine. Carotid arteries intimal wall thickness was not significantly changed in any of the studied groups. Although atherogenic ratios are not changed, the lowered apolipoprotein AI levels may suggest an increased risk for coronary heart disease.


Pediatrics International | 2010

Lead exposure and its association with pubertal development in school-age Egyptian children: Pilot study

Hoda Y. Tomoum; Gehan Ahmed Mostafa; Nanees Ahmed Ismail; Samah Mohammed Ahmed

Background:  The aim of the present study was to determine blood lead levels in a group of Egyptian school‐age children and assess its relationship to pubertal development.


Journal of Child Neurology | 2010

Infantile spinal muscular atrophy with respiratory distress type 1: a case report.

Abdulaziz AlSaman; Hoda Y. Tomoum

The condition, currently known as spinal muscular atrophy with respiratory distress type 1, is an unusual variant of spinal muscular atrophy type 1 that is characterized by early respiratory failure due to diaphragmatic paralysis. The defective gene, the immunoglobulin μ-binding protein 2 (IGHMBP2 gene), of this autosomal recessive disorder is located on chromosome 11q13 and encodes immunoglobulin μ-binding protein 2. The natural history and phenotypic spectrum of the disease are still not clear. The authors present the first genetically proven case of spinal muscular atrophy with respiratory distress type 1 to be reported from Saudi Arabia. The parents are first cousins and the causative gene sequencing revealed mutation in exon 7 reported for the first time in a homozygous form. The clinical scenario of the case is discussed. The findings in the muscle magnetic resonance imaging (MRI) are presented.

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