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Dive into the research topics where Hoffmann D is active.

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Featured researches published by Hoffmann D.


The New England Journal of Medicine | 1986

The reemergence of smokeless tobacco

Gregory N. Connolly; Deborah M. Winn; Stephen S. Hecht; Jack E. Henningfield; Bailus Walker; Hoffmann D

Smokeless tobacco (snuff and chewing tobacco) is reemerging as a popular form of tobacco, particularly among male adolescents. In different regions of the United States, from 8 to 36 percent of male high-school students are regular users. The use of smokeless tobacco has been shown to cause oral-pharyngeal cancer. The strongest link is with cancers of the cheek and gum. White mucosal lesions (leukoplakia) are found in 18 to 64 percent of users, often at the site where the tobacco was held. Other associations have been suggested for cancers of the esophagus, larynx, and pancreas. Nitrosamines, found in high concentrations in smokeless tobacco, most likely have a role in its carcinogenicity. Other health problems include periodontal disease, acute elevations of blood pressure, and dependence. In early 1986, after action at the state level, Congress enacted a federal law requiring health-warning labels on packages of smokeless tobacco and a ban on electronic advertising. Other regulatory measures under consideration include raising state and federal excise taxes, tightening controls on advertising, and prohibiting sales to minors. In view of the recent growth of this problem, policy makers are taking the opportunity to intervene with preventive measures to protect a new generation of tobacco users.


IARC scientific publications | 1984

Formation and analysis of N-nitrosamines in tobacco products and their endogenous formation in consumers.

Hoffmann D; Klaus D. Brunnemann; John D. Adams; Stephen S. Hecht


Journal of Agricultural and Food Chemistry | 1984

Roles of Tobacco Cellulose, Sugars, and Chlorogenic Acid as Precursors to Catechol in Cigarette Smoke

Steven G. Carmella; Stephen S. Hecht; T. C. Tso; Hoffmann D


Cancer Research | 1984

Identification of the Major Adducts Formed by Reaction of 5-Methylchrysene Anti-Dihydrodiol-Epoxides with DNA in Vitro

Assieh A. Melikian; Shantu Amin; Stephen S. Hecht; Hoffmann D; John Pataki; Ronald G. Harvey


Progress in Experimental Tumor Research | 1983

Skin Bioassays in Tobacco Carcinogenesis

Hoffmann D; Ernst L. Wynder; Abraham Rivenson; Edmond J. LaVoie; Stephen S. Hecht


IARC scientific publications | 1982

Tobacco specific N-nitrosamines: occurrence and bioassays.

Hoffmann D; John D. Adams; Klaus D. Brunnemann; Abraham Rivenson; Stephen S. Hecht


IARC scientific publications | 1980

Chemical studies on tobacco smoke LXVIII. Analysis of volatile and tobacco-specific nitrosamines in tobacco products.

Hoffmann D; John D. Adams; Piade Jj; Stephen S. Hecht


Progress in Experimental Tumor Research | 1979

Model studies in tobacco carcinogenesis with the Syrian golden hamster.

Hoffmann D; Abraham Rivenson; Stephen S. Hecht; J. Hilfrich; N. Kobayashi; Ernst L. Wynder


Archive | 1981

The Metabolism of Cyclic Nitrosamines

Stephen S. Hecht; G. David McCoy; Chi-Hong B. Chen; Hoffmann D


IARC scientific publications | 1991

Studies in tobacco carcinogenesis.

Hoffmann D; Melikian Aa; Brunnemann Kd

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Ruth Young

National Institutes of Health

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T. C. Tso

United States Department of Agriculture

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Andre Castonguay

National Institutes of Health

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Bailus Walker

National Institutes of Health

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Chi hong B. Chen

National Institutes of Health

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Deborah M. Winn

National Institutes of Health

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Dorothy Lin

National Institutes of Health

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G. D. McCoy

New York Medical College

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