Hoffmann D
United States Department of Agriculture
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The New England Journal of Medicine | 1986
Gregory N. Connolly; Deborah M. Winn; Stephen S. Hecht; Jack E. Henningfield; Bailus Walker; Hoffmann D
Smokeless tobacco (snuff and chewing tobacco) is reemerging as a popular form of tobacco, particularly among male adolescents. In different regions of the United States, from 8 to 36 percent of male high-school students are regular users. The use of smokeless tobacco has been shown to cause oral-pharyngeal cancer. The strongest link is with cancers of the cheek and gum. White mucosal lesions (leukoplakia) are found in 18 to 64 percent of users, often at the site where the tobacco was held. Other associations have been suggested for cancers of the esophagus, larynx, and pancreas. Nitrosamines, found in high concentrations in smokeless tobacco, most likely have a role in its carcinogenicity. Other health problems include periodontal disease, acute elevations of blood pressure, and dependence. In early 1986, after action at the state level, Congress enacted a federal law requiring health-warning labels on packages of smokeless tobacco and a ban on electronic advertising. Other regulatory measures under consideration include raising state and federal excise taxes, tightening controls on advertising, and prohibiting sales to minors. In view of the recent growth of this problem, policy makers are taking the opportunity to intervene with preventive measures to protect a new generation of tobacco users.
IARC scientific publications | 1984
Hoffmann D; Klaus D. Brunnemann; John D. Adams; Stephen S. Hecht
Journal of Agricultural and Food Chemistry | 1984
Steven G. Carmella; Stephen S. Hecht; T. C. Tso; Hoffmann D
Cancer Research | 1984
Assieh A. Melikian; Shantu Amin; Stephen S. Hecht; Hoffmann D; John Pataki; Ronald G. Harvey
Progress in Experimental Tumor Research | 1983
Hoffmann D; Ernst L. Wynder; Abraham Rivenson; Edmond J. LaVoie; Stephen S. Hecht
IARC scientific publications | 1982
Hoffmann D; John D. Adams; Klaus D. Brunnemann; Abraham Rivenson; Stephen S. Hecht
IARC scientific publications | 1980
Hoffmann D; John D. Adams; Piade Jj; Stephen S. Hecht
Progress in Experimental Tumor Research | 1979
Hoffmann D; Abraham Rivenson; Stephen S. Hecht; J. Hilfrich; N. Kobayashi; Ernst L. Wynder
Archive | 1981
Stephen S. Hecht; G. David McCoy; Chi-Hong B. Chen; Hoffmann D
IARC scientific publications | 1991
Hoffmann D; Melikian Aa; Brunnemann Kd