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Featured researches published by Hojung Kim.


Archives of Pharmacal Research | 2006

Relationships between the larval growth inhibition of Caenorhabditis elegans by apigenin derivatives and their structures.

Young-Ah Yoon; Hojung Kim; Yoongho Lim; Yhong-Hee Shim

Due to consumer reluctance to take synthetic drugs for nematode infections and the appearance of resistance to anthelminthic drugs, new drugs from natural products must be developed.Caenorhabditis elegans is one of the freely living nematodes and serves as a good model system for screening anthelminthic drugs. In this study, thirteen flavonoid derivatives were tested for anthelminthic activity and the relationships between their activities and structures were investigated. The structural information combined with the data for the larval growth inhibition ofC. elegans provided meaningful structural insights in the search for new anthelminthic drugs.


Bioorganic & Medicinal Chemistry Letters | 2009

HY251, a novel cell cycle inhibitor isolated from Aralia continentalis, induces G1 phase arrest via p53-dependent pathway in HeLa cells.

Ha Lim Oh; Haeyoung Lim; Youl-Hee Cho; Hyun Chul Koh; Hojung Kim; Yoongho Lim; Chul-Hoon Lee

This study was aimed to elucidate the novel structure of HY251 isolated from the roots of Aralia continentalis and to evaluate its detailed inhibition mechanisms on cell cycle progression in HeLa cells. The structure of HY251 was elucidated based on the interpretation of the NMR spectra, as 3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8a-decahydrocyclopenta[a]indene-3,3a,7a,8a-tetraol. The flow cytometric analysis revealed an appreciable G(1) phase arrest in HeLa cells treated with 100 microM of HY251. This HY251-induced G(1) phase arrest is associated with decreased expression of cyclin D3 and up-regulation of p21(CIP1) and p27(KIP1), via p53 phosphorylation at Ser-15 by transcriptional up-regulation of ATM, which resulted in increased hypophosphorylated pRb in HeLa cells.


Journal of Plant Physiology | 2008

Four glucosyltransferases from rice: cDNA cloning, expression, and characterization

Jae Hyung Ko; Bong Gyu Kim; Jeong Ho Kim; Hojung Kim; Chae Eun Lim; Jun Lim; Chan Lee; Yoongho Lim; Joong-Hoon Ahn


Bulletin of The Korean Chemical Society | 2006

NMR Data of Flavone Derivatives and Their Anti-oxidative Activities

Yeong-Hui Park; Yong-Uk Lee; Hojung Kim; Youngshim Lee; Young-Ah Yoon; Byeong-Ho Mun; Yu-Hun Jeong; Jung-Hun An; Yhong-Hee Shim; Yoongho Lim


Magnetic Resonance in Chemistry | 2006

Complete NMR signal assignments of flavonol derivatives.

Hojung Kim; Byoung-Ho Moon; Joong-Hoon Ahn; Yoongho Lim


Bioorganic & Medicinal Chemistry Letters | 2008

A flavonoid gossypin binds to cyclin-dependent kinase 2

Hojung Kim; Eunjung Lee; Jihye Kim; Bora Jung; Youhoon Chong; Joong-Hoon Ahn; Yoongho Lim


Bulletin of The Korean Chemical Society | 2006

Synthesis of Ermanin, 5,7-Dihydroxy-3,4'-dimethoxyflavone from Kaempferol, 3,5,7,4'-Tetrahydroxyflavone with Two O-Methyltransferases Expressed in E. coli

Bong Gyu Kim; Hojung Kim; Jeong Ho Kim; Yoongho Lim; Joong-Hoon Ahn


Journal of Microbiology and Biotechnology | 2007

Antimicrobial effects of flavone analogues and their structure-activity relationships.

Jungmo Young; Younghee Park; Yong-Uk Lee; Hojung Kim; Yhong-Hee Shim; Joong-Hoon Ahn; Yoongho Lim


Bulletin of The Korean Chemical Society | 2007

Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2

Hojung Kim; Eunjung Lee; Jihye Kim; Jin Young Kim; Haeyoung Lim; Chul-Hoon Lee; Joong-Hoon Ahn; Youhoon Chong; Yoongho Lim


Bulletin of The Korean Chemical Society | 2005

Synthesis of Naringenin Amino Acid Esters as Potential CDK2 Inhibitors

Jinyoung Kim; Youngshim Lee; Hojung Kim; Seock-Yong Kang; Kwang-su Park; Jun-Ho Cho; Yun-Yeong Lee; Byeong-Soo Kim; Yoongho Lim; Youhoon Chong

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