Hojung Kim
Konkuk University
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Publication
Featured researches published by Hojung Kim.
Archives of Pharmacal Research | 2006
Young-Ah Yoon; Hojung Kim; Yoongho Lim; Yhong-Hee Shim
Due to consumer reluctance to take synthetic drugs for nematode infections and the appearance of resistance to anthelminthic drugs, new drugs from natural products must be developed.Caenorhabditis elegans is one of the freely living nematodes and serves as a good model system for screening anthelminthic drugs. In this study, thirteen flavonoid derivatives were tested for anthelminthic activity and the relationships between their activities and structures were investigated. The structural information combined with the data for the larval growth inhibition ofC. elegans provided meaningful structural insights in the search for new anthelminthic drugs.
Bioorganic & Medicinal Chemistry Letters | 2009
Ha Lim Oh; Haeyoung Lim; Youl-Hee Cho; Hyun Chul Koh; Hojung Kim; Yoongho Lim; Chul-Hoon Lee
This study was aimed to elucidate the novel structure of HY251 isolated from the roots of Aralia continentalis and to evaluate its detailed inhibition mechanisms on cell cycle progression in HeLa cells. The structure of HY251 was elucidated based on the interpretation of the NMR spectra, as 3-propyl-2-vinyl-1,2,3,3a,3b,6,7,7a,8,8a-decahydrocyclopenta[a]indene-3,3a,7a,8a-tetraol. The flow cytometric analysis revealed an appreciable G(1) phase arrest in HeLa cells treated with 100 microM of HY251. This HY251-induced G(1) phase arrest is associated with decreased expression of cyclin D3 and up-regulation of p21(CIP1) and p27(KIP1), via p53 phosphorylation at Ser-15 by transcriptional up-regulation of ATM, which resulted in increased hypophosphorylated pRb in HeLa cells.
Journal of Plant Physiology | 2008
Jae Hyung Ko; Bong Gyu Kim; Jeong Ho Kim; Hojung Kim; Chae Eun Lim; Jun Lim; Chan Lee; Yoongho Lim; Joong-Hoon Ahn
Bulletin of The Korean Chemical Society | 2006
Yeong-Hui Park; Yong-Uk Lee; Hojung Kim; Youngshim Lee; Young-Ah Yoon; Byeong-Ho Mun; Yu-Hun Jeong; Jung-Hun An; Yhong-Hee Shim; Yoongho Lim
Magnetic Resonance in Chemistry | 2006
Hojung Kim; Byoung-Ho Moon; Joong-Hoon Ahn; Yoongho Lim
Bioorganic & Medicinal Chemistry Letters | 2008
Hojung Kim; Eunjung Lee; Jihye Kim; Bora Jung; Youhoon Chong; Joong-Hoon Ahn; Yoongho Lim
Bulletin of The Korean Chemical Society | 2006
Bong Gyu Kim; Hojung Kim; Jeong Ho Kim; Yoongho Lim; Joong-Hoon Ahn
Journal of Microbiology and Biotechnology | 2007
Jungmo Young; Younghee Park; Yong-Uk Lee; Hojung Kim; Yhong-Hee Shim; Joong-Hoon Ahn; Yoongho Lim
Bulletin of The Korean Chemical Society | 2007
Hojung Kim; Eunjung Lee; Jihye Kim; Jin Young Kim; Haeyoung Lim; Chul-Hoon Lee; Joong-Hoon Ahn; Youhoon Chong; Yoongho Lim
Bulletin of The Korean Chemical Society | 2005
Jinyoung Kim; Youngshim Lee; Hojung Kim; Seock-Yong Kang; Kwang-su Park; Jun-Ho Cho; Yun-Yeong Lee; Byeong-Soo Kim; Yoongho Lim; Youhoon Chong