Hong Dai

Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing a 2-Chloro-5-thiazolyl Moiety

A series of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety were synthesized. Their structures were confirmed by (1)H NMR, (13)C NMR, and elemental analysis. The preliminary bioassays showed that all of the title compounds had low acaricidal activity against Tetranychus cinnabarinus . However, most of them exhibited excellent insecticidal activity against Aphis medicagini at the dosage of 0.5 mg/mL, and some compounds still showed good insecticidal activity against A. medicagini even at the dosage of 0.2 mg/mL. Meanwhile, some title compounds displayed fungicidal and plant growth regulatory activities.

Synthesis and Insecticidal Activity of N-Substituted (1,3-Thiazole)alkyl Sulfoximine Derivatives

The N-substituted alkyl sulfoximine derivatives are a new chemical family of neonicotinoid insecticides. We have designed and synthesized 10 (1,3-thiazole)alkyl sulfoximine derivatives. All compounds were identified by (1)H and (13)C nuclear magnetic resonance (NMR), IR, and elemental analyses. Preliminary bioassays indicated that some title compounds exhibited good insecticidal activities at 10 mg/L against Myzus persicae . The relationship between structure and biological activity was also discussed.

Synthesis and herbicidal activities of 2-cyano-3-benzylaminoacrylates containing thiazole moiety.

Two series of novel 2-cyano-3-benzylaminoacrylates containing long-chain thiazole ring moiety were synthesized as herbicidal inhibitors of photosystem II (PS II) electron transportation. Their structures were confirmed by (1)H NMR and elemental analysis. The bioassay showed that these compounds retain high herbicidal activities and especially compounds 13a and 13h have excellent herbicidal activities.

Synthesis and Biological Activities Evaluation of New 4-(2,4-Difluorophenyl)-N-aryl-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine

Abstract Fifteen new thiazol-2-amine derivatives containing the 2,4-difluorophenyl unit and 1H-1,2,4-triazole moiety were synthesized. Their structures of all these new compounds have been confirmed by 1H NMR spectra and elemental analysis. The antifungal and plant-growth-regulatory activities of the title compounds are discussed.

1-Methyl-5-phen-oxy-3-trifluoro-methyl-1H-pyrazole-4-carbaldehyde oxime.

In the title compound, C12H10F3N3O2, the dihedral angle between the phenyl and pyrazole rings is 96.6 (3)°. In the crystal, pairs of O—H⋯N hydrogen bonds link the molecules, forming inversion dimers. Weak intermolecular C—H⋯F hydrogen bonds are also observed.

Synthesis and Biological Activity of 1 H -1,2,4-Triazole Alcohol Derivatives

Eight new 1 H -1,2,4-triazole alcohol derivatives containing a ferrocenyl moiety were synthesized. In addition, four unexpected compounds, which are the hydroxyl of the title compounds being methylated by methanol, were obtained. The structures of all these new compounds have been confirmed with 1 H NMR spectra, MS, and elemental analyses. The antifungal and plant growth regulatory activities of these compounds are discussed.

Synthesis and Bioactivity of Novel Pyridine Phenyl Ethers Bearing N-heterocycles

In order to find novel pyridine phenyl ether lead compounds, a series of novel pyridine phenyl ether derivatives containing N-heterocycles were prepared by the strategy of active substructure combination. Their structures were determined by H NMR, C NMR, IR and elemental analysis. Preliminary bioassay data displayed that some of the designed compounds exhibited good insecticidal activity. Additionally, some target compounds showed significant anti-tumor activities.

5-(3-Chloro-phen-ylsulfan-yl)-1-methyl-3-trifluoro-methyl-1H-pyrazole-4-carbaldehyde O-[(2-chloro-1,3-thia-zol-5-yl)meth-yl]oxime.

In the title compound, C16H11Cl2F3N4OS2, the benzene ring and the thiazole ring make dihedral angles of 83.2 (3) and 78.3 (3)°, respectively, with the pyrazole ring. The crystal packing shows S⋯N contacts of 3.309 (2) Å.

5-(4-Chloro­phen­oxy)-1-methyl-3-tri­fluoro­methyl-1H-pyrazole-4-carbaldehyde O-[(2-chloro­pyridin-5-yl)meth­yl]oxime

In the title molecule, C18H13Cl2F3N4O2, the intramolecular distance between the centroids of the benzene and pyridine rings is 3.953 (3) Å, and the trifluoromethyl group is rotationally disordered over two orientations in a 0.678 (19):0.322 (19) ratio. The crystal packing exhibits weak intermolecular C—H⋯F interactions.

2-(2,3-Dimethyl­phen­oxy)-1-(pyridin-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanone

The title compound, C17H16N4O2, a potent fungicidal agent, has been synthesized and its crystal structure determined. The dihedral angles between the planes of the pyridinyl and triazole rings, and between the substituted phenyl and triazole rings are 82.7 (2)° and 77.0 (3)°, respectively.