Jian‐Bing Liu

Synthesis and Evaluation of Novel Ferrocenyl Thiazole Derivatives as Anticancer Agents

Novel ferrocenyl‐containing thiazole derivatives have been synthesized from 2‐amino‐4‐ferrocenyl‐5‐(1H‐1,2,4‐triazole‐1‐yl)‐1,3‐thiazole and substituted benzoyl chloride. The structures of these compounds have been characterized by 1H NMR, elemental analysis and X‐ray diffraction analysis. Evaluation of anticancer activities showed that some of them possessed some degree of anticancer activity.

Synthesis and Biological Activity of 1 H -1,2,4-Triazole Alcohol Derivatives

Eight new 1 H -1,2,4-triazole alcohol derivatives containing a ferrocenyl moiety were synthesized. In addition, four unexpected compounds, which are the hydroxyl of the title compounds being methylated by methanol, were obtained. The structures of all these new compounds have been confirmed with 1 H NMR spectra, MS, and elemental analyses. The antifungal and plant growth regulatory activities of these compounds are discussed.

2-(2,3-Dimethyl­phen­oxy)-1-(pyridin-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanone

The title compound, C17H16N4O2, a potent fungicidal agent, has been synthesized and its crystal structure determined. The dihedral angles between the planes of the pyridinyl and triazole rings, and between the substituted phenyl and triazole rings are 82.7 (2)° and 77.0 (3)°, respectively.