Hong-Wu Zhao
Beijing University of Technology
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Publication
Featured researches published by Hong-Wu Zhao.
Organic Letters | 2017
Hong-Wu Zhao; Yue-Yang Liu; Yu-Di Zhao; Hai-Liang Pang; Xiao-Qin Chen; Xiu-Qing Song; Ting Tian; Bo Li; Zhao Yang; Juan Du; Ning-Ning Feng
In the presence of TMSCl, the [3 + 2] cycloaddition of oxazol-5-(4H)-ones with nitrones proceeded smoothly and furnished the desired isoxazolidin-5-ones with high diastereoselectivities in reasonable chemical yields. The chemical structure of the title compounds was firmly confirmed by X-ray single-crystal structure analysis.
RSC Advances | 2017
Hong-Wu Zhao; Yu-Di Zhao; Yue-Yang Liu; Li-Jiao Zhao; Ning-Ning Feng; Hai-Liang Pang; Xiao-Qin Chen; Xiu-Qing Song; Juan Du
In the presence of Na2CO3, azaoxyallyl cations in situ generated from α-halohydroxamates with nitrones readily underwent [3 + 3] cycloaddition, and gave rise to 1,2,4-oxadiazinan-5-one derivatives in 56–99% chemical yields. The chemical structure of the title compounds was unambiguously identified by X-ray single crystal structure analysis.
RSC Advances | 2016
Hong-Wu Zhao; Hai-Liang Pang; Bo Li; Ting Tian; Xiao-Qin Chen; Xiu-Qing Song; Wei Meng; Zhao Yang; Yue-Yang Liu; Yu-Di Zhao
In the presence of K2CO3, the [4 + 2] cycloaddition of α-halogeno hydrazones with azodicarboxylic acid derivatives proceeded efficiently, and delivered novel non-aromatic 1,2,3,6-tetrahydro-1,2,3,4-tetrazines in moderate to excellent chemical yields.
RSC Advances | 2015
Hong-Wu Zhao; Xiao-Qin Chen; Zhao Yang; Ting Tian; Bo Li; Wei Meng; Xiu-Qing Song; Hai-Liang Pang
In the presence of Et3N, the [3 + 2] cycloaddition of isatins, 2-(aminomethyl)pyridine and isatin-based imines proceeded readily, and furnished novel imidazolidine-dispirooxindoles in up to 84% yield with up to >99:1 diastereoselectivity. The relative configuration of the imidazolidine-dispirooxindoles was firmly confirmed on the basis of X-ray single crystal structure analysis. The reaction mechanism was assumed to account for the diastereoselective formation of the imidazolidine-dispirooxindoles.
RSC Advances | 2016
Hong-Wu Zhao; Bo Li; Ting Tian; Xiu-Qing Song; Hai-Liang Pang; Xiao-Qin Chen; Zhao Yang; Wei Meng
In the presence of 10 mol% of Na2CO3, the desired imidazolidine-spirooxindoles were obtained in 81–99% yield with up to 99 : 1 dr by means of the diastereoselective [3 + 2] cycloaddition of N-acylhydrazine-derived imines with 3-isothiocyanato oxindoles. Single-crystal X-ray structure analysis was conducted to determine the relative stereochemistry of the imidazolidine-spirooxindoles. Diastereoselective access to the imidazolidine-spirooxindoles was hypothesized by the proposed mechanism.
RSC Advances | 2017
Hong-Wu Zhao; Yu-Di Zhao; Yue-Yang Liu; Li-Jiao Zhao; Xiu-Qing Song; Xiao-Qin Chen; Hai-Liang Pang; Juan Du; Ning-Ning Feng
Promoted by Et3N, the 1,3-dipolar [3 + 3] cycloaddition of α-halohydroxamate-based azaoxyallylcations with hydrazonoyl chloride-derived nitrile imines occurred efficiently, and furnished desired products in acceptable chemical yields. The chemical structure of the title compounds was firmly confirmed by an X-ray single crystal structure analysis.
RSC Advances | 2017
Hong-Wu Zhao; Hai-Liang Pang; Yu-Di Zhao; Yue-Yang Liu; Li-Jiao Zhao; Xiao-Qin Chen; Xiu-Qing Song; Ning-Ning Feng; Juan Du
In the presence of sodium carbonate, the [4 + 2] cycloaddition of α-halogeno hydrazones to imines proceeded readily, and furnished 2,3,4,5-tetrahydro-1,2,4-triazines in moderate to high chemical yields.
Synthetic Communications | 2013
Jin-Ling Li; Hong-Wu Zhao; Xiao Qin; Jin Cui; Shi Su; Hai-Long Li; Yuan-Yuan Yue; Xiu-Qing Song
Abstract A series of chiral phenylpyridines possessing a fused chiral bridge were synthesized diastereoselectively via cascade cyclizations, where N-acyliminium ions including an enantiopure α-amino acid residue were involved. The absolute configuration of the synthesized phenylpyridines was identified unambiguously by using nuclear Overhauser effect difference and circular dichroism (CD) measurements on the basis of literature methods. [Supplementary materials are available for this article. Go to the publishers online edition of Synthetic Communications® for the following free supplemental resources: Full experimental and spectral details.] GRAPHICAL ABSTRACT
Synthetic Communications | 2009
Hong-Wu Zhao; Rugang Zhong; Hong Yan; Wei Yang; Jin Cui; Wenting Hua
Abstract An array of novel chiral aromatic heterocyclic macrocycles, which may show potential enantiomeric recognition to variable D- and L-amino acids, were synthesized in acceptable yield. The desired macrocycles 3a–c and 4a–c were obtained via the condensation reaction of chiral diamine intermediates 2a–c with 2,5-bis(o-chloroformylphenyl)-1,3,4-triazole 5 in a presence of Et3N in a highly diluted dichloromethane solution at room temperature.
Journal of Organic Chemistry | 2018
Hong-Wu Zhao; Ning-Ning Feng; Jia-Ming Guo; Juan Du; Wan-Qiu Ding; Li-Ru Wang; Xiu-Qing Song
Under the catalysis of chiral palladium(0)/ligand complex, the [4 + 2] cycloaddition between vinyl benzoxazinanones and barbiturate-based olefins proceeded readily and provided barbiturate-fused spirotetrahydroquinolines in up to 96% chemical yield with up to >99:1 dr and 97% ee. The absolute configuration of barbiturate-fused spirotetrahydroquinolines was clearly identified by X-ray single crystal structure analysis. The reaction mechanism was proposed to shed light on the enantioselective formation of barbiturate-fused spirotetrahydroquinolines.