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Hong Yong

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Publication

Featured researches published by Hong Yong.

Bioorganic & Medicinal Chemistry Letters | 2000

Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives.

Richard F. Clark; Zhenkun Ma; Sanyi Wang; George Griesgraber; Michael D. Tufano; Hong Yong; Leping Li; Xiaolin Zhang; Angela M. Nilius; Daniel T. W. Chu; Yat Sun Or

A series of novel 6-O-substituted erythromycin A derivatives has been synthesized. Good in vitro antibacterial activity has been demonstrated for analogues incorporating a variety of structural features. The methodology disclosed is expected to find application in the design of future macrolide antibiotics that target the prevalent bacterial resistance problem.

Archive | 2006

Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

Jeffrey J. Rohde; Qi Shuai; James T. Link; Jyoti R. Patel; Jurgen Dinges; Bryan K. Sorensen; Hong Yong; Vince S.C. Yeh; Ravi Kurukulasuriya

Journal of Medicinal Chemistry | 2001

Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens

Zhenkun Ma; Richard F. Clark; Antony A. Brazzale; Sanyi Wang; Michael Rupp; Leping Li; George W. Griesgraber; Suoming Zhang; Hong Yong; Ly Tam Phan; Peter A. Nemoto; Daniel T. W. Chu; Jacob J. Plattner; Xiaolin Zhang; Ping Zhong; Zhensheng Cao; Angela M. Nilius; Virginia D. Shortridge; Robert K. Flamm; Michael J. Mitten; Jon Meulbroek; Patty Ewing; Jeff Alder; Yat Sun Or

Archive | 2008

Treatment of central nervous system disorders

R. Scott Bitner; Kaitlin E. Browman; Michael E. Brune; Yixian Chen; Jurgen Dinges; Karla Drescher; Peer B. Jacobson; Hwan-Soo Jae; Ravi Kurukulasuriya; James T. Link; David J. Madar; Jyoti R. Patel; Marina A. Pliushchev; Jeffrey J. Rohde; Lynne E. Rueter; Qi Shuai; Bryan K. Sorensen; Jiahong Wang; Karsten Wicke; Martin Winn; Dariusz Wodka; Vince Yeh; Hong Yong

Journal of Medicinal Chemistry | 2006

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279) : A very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes

David J. Madar; Hana Kopecka; Daisy Pireh; Hong Yong; Zhonghua Pei; Xiaofeng Li; Paul E. Wiedeman; Stevan W. Djuric; Thomas W. von Geldern; Michael G. Fickes; Lakshmi Bhagavatula; Todd Mcdermott; Steven J. Wittenberger; Steven J. Richards; Kenton L. Longenecker; Kent D. Stewart; Thomas H. Lubben; Stephen J. Ballaron; Michael A. Stashko; Michelle A. Long; Heidi Wells; Bradley A. Zinker; Amanda K. Mika; David W. A. Beno; Anita J. Kempf-Grote; James S. Polakowski; Jason A. Segreti; Glenn A. Reinhart; Ryan M. Fryer; Hing L. Sham

Bioorganic & Medicinal Chemistry Letters | 2006

Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors

Vince S.C. Yeh; Jyoti R. Patel; Hong Yong; Ravi Kurukulasuriya; Steven Fung; Katina Monzon; William J. Chiou; Jiahong Wang; DeAnne Stolarik; Hovis M. Imade; David W. A. Beno; Michael E. Brune; Peer B. Jacobson; Hing L. Sham; James T. Link

Bioorganic & Medicinal Chemistry Letters | 2004

Synthesis and antibacterial activity of novel bifunctional macrolides.

Irini Akritopoulou-Zanze; Kathleen M. Phelan; Thomas Marron; Hong Yong; Zhenkun Ma; Greg G. Stone; Melissa M. Daly; Dena M Hensey; Angela M. Nilius; Stevan W. Djuric

Bioorganic & Medicinal Chemistry Letters | 2005

Design, synthesis and structure–activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae

Hong Yong; Yu Gui Gu; Richard F. Clark; Thomas Marron; Zhenkun Ma; Niru B. Soni; Gregory G. Stone; Angela M. Nilius; Kennan C. Marsh; Stevan W. Djuric

Archive | 2001

Anti-infective agents useful against multidrug-resistant strains of bacteria

Zhenkun Ma; Peter A. Nemoto; Suoming Zhang; Hong Yong; Yat Sun Or

Archive | 2003

Tricyclic macrolide antibacterial compounds

Yu-Gui Gu; Zhenkun Ma; Hong Yong

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Collaboration

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James T. Link

Icos

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Bryan K. Sorensen

University of Pittsburgh

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Jeffrey J. Rohde

Harvard University

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Stevan W. Djuric

Albert Einstein College of Medicine

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David J. Madar

Indiana University Bloomington

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Martin Winn

University of Pittsburgh

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Richard F. Clark

University of California

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Kent D. Stewart

Research Triangle Park

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Kenton L. Longenecker

University of Virginia

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Michael D. Tufano

University of Illinois at Chicago

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