David J. Madar
Indiana University Bloomington
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by David J. Madar.
Journal of Medicinal Chemistry | 2015
Milan Bruncko; Le Wang; George S. Sheppard; Darren C. Phillips; Stephen K. Tahir; John Xue; Scott A. Erickson; Steve D. Fidanze; Elizabeth E. Fry; Lisa A. Hasvold; Gary J. Jenkins; Sha Jin; Russell A. Judge; Peter Kovar; David J. Madar; Paul Nimmer; Chang Park; Andrew M. Petros; Saul H. Rosenberg; Morey L. Smith; Xiaohong Song; Chaohong Sun; Zhi-Fu Tao; Xilu Wang; Yu Xiao; Haichao Zhang; Chris Tse; Joel D. Leverson; Steve W. Elmore; Andrew J. Souers
Myeloid cell leukemia 1 (MCL-1) is a BCL-2 family protein that has been implicated in the progression and survival of multiple tumor types. Herein we report a series of MCL-1 inhibitors that emanated from a high throughput screening (HTS) hit and progressed via iterative cycles of structure-guided design. Advanced compounds from this series exhibited subnanomolar affinity for MCL-1 and excellent selectivity over other BCL-2 family proteins as well as multiple kinases and GPCRs. In a MCL-1 dependent human tumor cell line, administration of compound 30b rapidly induced caspase activation with associated loss in cell viability. The small molecules described herein thus comprise effective tools for studying MCL-1 biology.
Tetrahedron Letters | 2001
David J. Madar; Hana Kopecka; Daisy Pireh; Jonathan Pease; Marina Pliushchev; Richard J. Sciotti; Paul E. Wiedeman; Stevan W. Djuric
Abstract A method for the intermolecular coupling of aryl bromides and oxazolidinones is described. Application to intermediates useful for the preparation of a known class of antibacterial agent and the synthesis of the known antibacterial oxazolidinone Dup-721 are described.
Tetrahedron Letters | 1993
William R. Roush; David J. Madar
Abstract The highly functionalized streptovaricin-damavaricin D aromatic precursors 12 and 15 have been prepared and coupled with propionaldehyde or unsaturated aldehydes 16 and 18 via aryllithium intermediates to give 2, 3 and 19.
Journal of Medicinal Chemistry | 2000
Stevan W. Djuric; Nwe Y. BaMaung; Basha A; Liu H; Luly; David J. Madar; Sciotti Rj; Tu Np; Wagenaar Fl; Paul E. Wiedeman; Zhou X; Stephen J. Ballaron; Joy Bauch; Chen Yw; Chiou Xg; Thomas A. Fey; Donna M. Gauvin; Gubbins E; Gin C. Hsieh; Kennan C. Marsh; Karl W. Mollison; Pong M; Shaughnessy Tk; Sheets Mp; Morey L. Smith; James M. Trevillyan; Usha Warrior; Wegner Cd; George W. Carter
Archive | 2001
David J. Madar; Daisy Pireh; Hana Kopecka; Steven W. Djuric; Paul E. Wiedeman
Archive | 1999
Nwe Y. BaMaung; Anwer Basha; Stevan W. Djuric; Earl J. Gubbins; Jay R. Luly; Noah P. Tu; David J. Madar; Usha Warrior; Paul E. Wiedeman; Xun Zhou; Richard J. Sciotti; Frank L. Wagenaar
Archive | 2008
R. Scott Bitner; Kaitlin E. Browman; Michael E. Brune; Yixian Chen; Jurgen Dinges; Karla Drescher; Peer B. Jacobson; Hwan-Soo Jae; Ravi Kurukulasuriya; James T. Link; David J. Madar; Jyoti R. Patel; Marina A. Pliushchev; Jeffrey J. Rohde; Lynne E. Rueter; Qi Shuai; Bryan K. Sorensen; Jiahong Wang; Karsten Wicke; Martin Winn; Dariusz Wodka; Vince Yeh; Hong Yong
Journal of Medicinal Chemistry | 2006
Zhonghua Pei; Xiaofeng Li; Kenton L. Longenecker; Thomas W. von Geldern; Paul E. Wiedeman; Thomas H. Lubben; Bradley A. Zinker; Kent D. Stewart; Stephen J. Ballaron; Michael A. Stashko; Amanda K. Mika; David W. A. Beno; Michelle A. Long; Heidi Wells; Anita J. Kempf-Grote; David J. Madar; Todd S. McDermott; Lakshmi Bhagavatula; Michael G. Fickes; Daisy Pireh; Larry R. Solomon; Marc R. Lake; Rohinton Edalji; Elizabeth H. Fry; Hing L. Sham; James M. Trevillyan
Archive | 2008
Xilu Wang; Xiaohong Song; Steven W. Elmore; Milan Bruncko; David J. Madar; Andrew J. Souers; Lisa A. Hasvold; Le Wang; Zhi-Fu Tao; Aaron R. Kunzer
Biochemistry | 2006
Kenton L. Longenecker; Kent D. Stewart; David J. Madar; Clarissa Jakob; Elizabeth H. Fry; Sherwin Wilk; Chun W. Lin; Stephen J. Ballaron; Michael A. Stashko; Thomas H. Lubben; Hong Yong; Daisy Pireh; Zhonghua Pei; Fatima Z. Basha; Paul E. Wiedeman; Thomas W. von Geldern; and James M. Trevillyan; Vincent S. Stoll