Hongjie Pan

Enantioselective 6-exo-Bromoaminocyclization of Homoallylic N-Tosylcarbamates Catalyzed by a Novel Monophosphine-Sc(OTf)3 Complex

A highly enantioselective 6-exo-bromoaminocyclization of (E)-homoallylic N-tosylcarbamates catalyzed by a novel monophosphine-Sc(OTf)3 complex is described, giving a wide variety of optically active oxazinanones with high enantioselectivities.

Organocatalytic asymmetric biomimetic transamination of α-keto acetals to chiral α-amino acetals

This paper describes a chiral base-catalyzed asymmetric biomimetic transamination of α-keto acetals. A wide variety of α-amino acetals containing various functional groups can be synthesized in 50–85% yield and 82–86% ee.

A Concise Approach to the Dalesconol Skeleton

A rapid approach to the skeleton of dalesconol A and B, unprecedented immunosuppressants, has been achieved through a convergent strategy featuring a carbocation-mediated dearomatization-cyclization and a following one-pot consecutive operation.

Phosphine Oxide–Sc(OTf)3 Catalyzed Highly Regio- and Enantioselective Bromoaminocyclization of (E)-Cinnamyl Tosylcarbamates. An Approach to a Class of Synthetically Versatile Functionalized Molecules

A highly regio- and enantioselective bromoaminocyclization of (E)-cinnamyl tosylcarbamates catalyzed by a chiral phosphine oxide-Sc(OTf)3 complex is described. A wide variety of optically active aryl 5-bromo-1,3-oxazinan-2-ones can be obtained with high yield and enantioselectivity.

A Facile Approach to Optically Active Hydroquinoline‐2‐carboxylates by a One‐Pot Asymmetric Michael/Transamination/Cyclization Process

An efficient one-pot synthesis of optically active hydroquinoline-2-carboxylates from 1,3-cyclohexanediones, β,γ-unsaturated α-keto ester, and benzylamine in the presence of a chiral base catalyst and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) with good diastereoselectivity and high enantioselectivity is described. The reaction proceeds by a sequential asymmetric Michael/transamination/cyclization process.

Synthesis of Optically Active Deuterated Primary Amines via Reduction of N-tert-Butanesulfinyl Aldimines

Optically active deuterated primary amines have been obtained with 78-98% ees from chiral N-tert-butanesulfinyl aldimines via reduction with N-Selectride and subsequent alcoholysis.

Phosphine oxide-Sc(OTf) 3 catalyzed enantioselective bromoaminocyclization of tri -substituted allyl N -tosylcarbamates

Phosphine oxide-Sc(OTf)3 catalyzed regio- and enantioselective bromoaminocyclization of tri-substituted allyl N-tosylcarbamates is described. A wide variety of optically active tertiary 5-bromo-1,3-oxazinan-2-ones can be obtained with high regio-and enantioselectivity.

CCDC 1417724: Experimental Crystal Structure Determination

Related Article: Hongjie Pan, Hu Huang, Weigang Liu, Hua Tian, and Yian Shi|2016|Org.Lett.|18|896|doi:10.1021/acs.orglett.5b03459