Howard Schachter

Ulcerative and Granulomatous Colitis—Validity of Differential Diagnostic Criteria: A Study of 100 Patients Treated by Total Colectomy

Excerpt One hundred patients with inflammatory disease of the colon treated by total colectomy during 1936-67 were subjected to independent clinical, pathologic, and radiologic restudy. Twenty-one ...

Consumption Coagulopathy in Miliary Tuberculosis

Abstract A 56-year-old woman required hospitalization and endotracheal intubation because of progressive respiratory distress associated with bilateral diffuse pulmonary infiltrates. Within 12 hr s...

Surgery and clinical progression in patients with Crohn's disease of the small and large intestine

Abstract Crohns disease frequently has been contrasted with ulcerative colitis, with emphasis upon the curative aspect of total colectomy in ulcerative colitis. The anatomic separation of these disorders has become less distinct in recent years, with the recognition of a type of tissue reaction similar to that of regional enteritis extending beyond the ileocecal valve to involve the colon. The extent and severity of recurrent Crohns disease demonstrated pathologically or radiologically do not always correlate with clinical signs and symptoms. In most studies this lack of correlation is not clearly indicated, nor is the nature of the clinical recurrence defined. In addition, little mention is made of the physiologic disability which may occur after surgery in the absence of anatomic recurrence. Selected cases illustrate the variety and magnitude of the clinical complications which may follow surgery for Crohns disease. These problems include the progression of the disease with recurrent fistulas, intestinal obstruction, and bleeding; the problems secondary to bowel resection, including postresectional malabsorption, diarrhea, and complications of ileostomy; and the occasionally relentless fatal course of granulomatous (Crohns) disease of the small and large intestine.

Ulcerative and Crohn's (Granulomatous) Colitis

Many cases originally diagnosed as chronic ulcerative colitis have been reclassified as Crohns disease of the colon. The clinical, radiographic and pathologic features of these two diseases often overlap, but characteristic features allow differentiation in most instances. Differential diagnosis is most helpful to the clinician in his consideration of complications, surgical management, and overall prognosis.

Crohnʼs Disease of the Gastrointestinal Tract

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