Hsin-Yu Huang

New Syntheses of 1-Benzoyltetrahydroisoquinoline Derivatives Using Polymer-supported Bis(trifluoroacetoxyiodo)benzene

The reaction of N-benzenesulfonyl-β-phenethylamines with α-benzoyl sulfides using polymer-supported bis(trifluoroacetoxyiodo)benzene (PSBTI) gives moderate to good yields of the corresponding 1-benzoyltetrahydroisoquinoline derivatives.

Allylation of meldrum's acids by allylic alcohols using tetrakis[triphenylphosphine]-palladium(0) catalysts

Meldrums acids can be allylated by allylic alcohols using tetrakis[triphenylphosphine]palladium(0) [(PPh 3 ) 4 Pd] as a catalyst in benzene at 80°C without prior activation of allylic hydroxy group.

Ionic liquid in organic synthesis : The pictet-spengler reaction

We have demonstrated the use of the room temperature ionic liquid, 1-butyl-3-methylimidazoliumhexafluorophosphate ([bmim]PF 6 ), as an environmentally benign solvent for the preparation of 2-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid ethyl ester derivatives through Pictet-Spengler reaction using phenyliodine(III) bis(trifluoroacetate) (PIFA) under mild conditions.