Huaijun Zhu

Infrared spectroscopic analysis of 5,248 urinary stones from Chinese patients presenting with the first stone episode

A series of 5,248 urinary stones was analyzed by Fourier transform infrared spectroscopy between 1999 and 2008. This study evaluated the percentage of each stone type and the association with sex and age in Chinese stone formers presenting with the first stone episode. The overall sex ratio (male:female) was 2.34:1. Results showed that the preponderant type of stone was calcium oxalate, followed by carbapatite, anhydrous uric acid, struvite and cystine. Struvite stones in this study accounted for a relatively low rate compared to that reported by others. Of 5,248 stones, only 38.1% had one component, 42.5% consisted of two components, and 20.4% consisted of three components. Our results also showed the higher percentage of carbapatite stones in females than in males and the increment of anhydrous uric acid stones with age. In addition, the percentage of calcium oxalate stones decreased with increase in the percentage of carbapatite stones over the period.

The effect of plum juice on the prevention of struvite calculus formation in vitro

Study Type – Prevention (cohort)

Greater and Lesser Ischiadic Foramina as Path of Shock Wave Lithotripsy for Distal Ureteral Stone in Children

PURPOSE We evaluated the efficacy and safety of shock wave lithotripsy in the supine position through the greater and lesser ischiadic foramina as a path of shock wave to treat distal ureteral stones in young children. MATERIALS AND METHODS We treated 22 young children with distal urinary calculi using the Dornier Compact S lithotriptor between 1997 and 2007. The study population consisted of 15 boys and 7 girls 6 months to 7 years old (mean +/- SD 5.4 +/- 2.1 years). Stone size ranged from 5 to 16 mm (mean 6.8). All patients were treated in the supine position under dissociative anesthesia with ketamine. The focused shock wave targeted the stone in the distal ureter through the greater and lesser ischiadic foramina. RESULTS Number of shocks ranged from 600 to 3,000 (mean +/- SD 2,346.2 +/- 483.7). Energy per pulse ranged from level 4 to 5 (mean 4.5). Treatment time varied from 20 to 40 minutes (mean 31). Stone-free rate at 2 weeks after lithotripsy was 77.3%, which increased to 100% at 3 months after a single lithotripsy session. No serious side effects were observed. CONCLUSIONS Shock wave lithotripsy in the supine position through the greater and lesser ischiadic foramina as the path of shock wave treats distal ureteral stones in young children with an excellent success rate and few side effects.

Plasma interleukin-22 levels are associated with prediabetes and type 2 diabetes in the Han Chinese population

The objective of the present study was to investigate the relationship between plasma interleukin‐22 (IL‐22) levels and prediabetes or type 2 diabetes, and search the relevance between plasma concentrations of IL‐22 and selected diabetes risk factors in Chinese people.

Comparison of Efficacy of German and Chinese Electromagnetic Shock Wave Lithotripters: Dornier Compact S vs Huikang MZ-SWL-V

OBJECTIVES To compare the treatment efficacy of Dornier Compact S and a Chinese electromagnetic shock wave lithotripter (Huikang MZ-SWL-V) in a large series. METHODS We retrospectively reviewed the outcome of shock wave lithotripsy (SWL) in 13,954 consecutive patients with upper urinary tract stones from December 1996 to December 2008 with Dornier Compact S (9124 cases) and Huikang MZ-SWL-V (4830 cases). An intramuscular injection of 50 mg pethidine was given to the patients with Dornier Compact S but not to those with Huikang MZ-SWL-V. Treatment outcomes were assessed by the stone-free rate at three months, the retreatment rate, the auxiliary procedure rate, and the effectiveness quotient. The pain scores were evaluated by visual analog scales, where 0 = pain and 10 = unbearable pain. RESULTS The overall stone-free rate at 3 months, retreatment rate, and ancillary procedure rate for Dornier Compact S were 95.9%, 13.4%, and 2.2%, respectively, and they were 85%, 29.6%, and 10.2%, respectively, for Huikang MZ-SWL-V. The overall efficiency quotients of Dornier Compact S and Huikang MZ-SWL-V were 83% and 60.8%, respectively. However, the pain scores in the Dornier group (6-10) were higher than those in the Huikang group (1-5). Three clinically significant subcapsular hematomas were detected in the Dornier group but there were none in the Huikang group. CONCLUSIONS Dornier Compact S is more effective than Huikang MZ-SWL-V, but SWL with Huikang machine could be performed with milder pain and without analgesia, and a lower significant hematoma rate was observed in Huikang group.

NUDT15 R139C Variants Increase the Risk of Azathioprine-induced Leukopenia in Chinese Autoimmune Patients

The aim of this study was to investigate the influence of NUDT15 R139C, thiopurine S-methyltransferase (TPMT), and 6-TGN on azathioprine (AZA) induced leukopenia in Chinese autoimmune patients. Among 87 enrolled patients, 23 (26.4%) had leukopenia. The NUDT15 R139C variant was associated with leukopenia (p = 1.86 × 10−7; OR: 7.59; 95% CI: 3.16–18.21). However, TPMT genotype was not shown to be correlated with the incidence of leukopenia (p = 0.95). There was no significant difference of 6-TGN concentration between patients with or without leukopenia (p = 0.15) and no association was found in patients with NUDT15 R139C variants alleles (p = 0.62). Finally, we found that the range of 6-TGN concentrations in autoimmune diseases was much lower than the established 6-TGN monitoring range for inflammatory bowel diseases. Therefore, the variant of NUDT15 R139C is strongly associated with AZA-induced leukopenia in Chinese patients with various autoimmune diseases such as systemic lupus erythematosus, Sjögrens syndrome, etc.