Huang Ding
Xinjiang Medical University
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Publication
Featured researches published by Huang Ding.
Heart | 2010
Liang Xiaohui; Xu Xinjuan; Ma Yanping; Sun Lihua; Ma Yitong; Huang Ding; Yang Yining
Objective To investigate augmentation index (AIx) and the affecting factors in Xinjiang Uygur health adults. Methods The total of 2366 Uygur natural adults were investigated. 559 health adults (male 251, female 308) were selected in the study and the mean age was (44.95±11.87) years. All the subjects were measured the following indexes: questionnaire, physical examination, fasting blood glucose, blood lipid, renal function and C-reactive protein (CRP). Central systolic blood pressure (cSBP) and central augmentation index (AIx) were measured by Sphygmocor. Results AIx in female was higher than in male (male: 18.52±11.27, female: 29.84±8.44, p<0.05). The same result was found in different age groups. Unadjusted correlation analysis showed AIx was positively related to age in both genders (male: r=0.548, female=0.405, p<0.05), as well as adjusted other influential factors (male: r=0.182, female=0.234, p<0.05). Multivariate regression analysis showed that cSBP, systolic blood pressure (SBP), age, weight and CRP were main factors which affected AIx in male, while age, cSBP, SBP, height and CRP were main factors which affected AIx in female. Conclusion AIx in female was higher than in male. AIx was positively related to age in both genders. Age, cSBP, SBP and CRP were main factors affected AIx in Xinjiang Uygur health adults.
Heart | 2010
Yu Zixiang; Ma Yitong; Yang Yining; Huang Ding; Ma Xiang; Liu Fen
Objective To estimate the prevalence of metabolic syndrome (MS) in Xinjiang Kazak populations. Methods A cross sectional study was conducted in 1610 kazak participants aged from 19 to 98 (mean±SD, 46.7±12; 654 men and 956 women) year in Xinjiang Yili. The International Diabetes Federation consensus worldwide definition in 2005 was used in the study. According to IDF 2005 criteria, populations were divided into MS group and non-MS group. Results The crude prevalence rate of MS by the IDF 2005 criteria was 40.1% (44.8% in men and 36.9% in women). Conclusions MS is highly prevalent in Kazak populations in, Xinjiang, particularly among men. To find out high-risk MS groups is an important measure for preventing early atherosclerosis.
Heart | 2010
Xie Xiang; Ma Yitong; Yang Yining; Fu Zhenyan; Li Xiaomei; Huang Ding; Ma Xiang; Chen Bangdang; Liu Fen
Background Both Low plasma HDL cholesterol (HDL-C) and inflammatory responses are associated with an increased risk of coronary artery disease (CAD). Serum amyloid A protein (SAA) is not only an inflammatory factor but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of HDL. However, the relationship between genetic polymorphisms of SAA and CAD remains unclear. Methods 4 Single Nucleotide Polymorphisms (SNPs) (rs12218, rs1059559, rs2229338, and rs2468844) of SAA1 and SAA2 gene were genotyped in 1580 CAD patients and 1914 age- and sex-matched controls by the use of PCR-restriction fragment length polymorphism (PCR-RFLP) analysis. Results The CC genotype and C allele of rs12218 and the GG genotype and G allele of rs2468844 were more common in the CAD patients than in the control subjects, respectively (all p<0.001). After adjusted for diabetes mellitus, hypertension, smoking, drinking and lipid disorders by use of logistic regression, the SNPs rs12218 (OR=5.906, 95% CI 2.877 to 12.124, p<0.001) and rs2468844 (OR=4.102, 95% CI 2.018 to 8.129, p<0.001) still differed significantly between the CAD patients and control subjects. Conclusion These data suggest that genetic polymorphisms of SAA1/2 gene significantly increased the risk of CAD in a Chinese Han population.
Heart | 2010
Xie Xiang; Ma Yitong; Yan Yining; Fu Zhenyan; Li Xiaomei; Huang Ding
Aims Serum amyloid A protein (SAA) is not only an inflammatory factor, but also an apolipoprotein that can replace apolipoprotein A1 (apoA1) as the major apolipoprotein of HDL, which has been linked to atherosclerosis. However, the relationship between genetic polymorphisms and common carotid artery intima-media thickness (IMT) in healthy subjects remains unclear. We investigated the role of the SAA1 and SAA2 gene polymorphisms with IMT in a cohort of healthy subjects participating in the Cardiovascular Risk Survey (CRS) study. Methods Anthropometric and B-mode ultrasound of the carotid IMT were measured in 1914 subjects (849 men; 1065 women) recruited from 7 cities in Xinjiang, the west China. Four SNPs (rs12218, rs2229338, rs1059559, and rs2468844) were genotyped by use of PCR—restriction fragment length polymorphism (PCR-RFLP) method. Results There was significant difference between mutational genotype (CC+CT genotype) and wild genotype (TT genotype) of rs12218 in carotid IMT [(0.070±0.03) cm vs (0.084±0.03) cm; p<0.001)], and the difference remains significant after multi-adjusted (adjusted for the sex, age, blood pressure, BMI and HDL) [(0.068±0.002 cm vs 0.081±0.003 p =0.008)]. This relationship was also observed in rs246 8844 after multi-adjusted but did not found in rs222 9338 and rs105 9559 before and after multi-adjusted. Conclusions Both rs12218 of the SAA1 gene and rs246 8844 of SAA2 gene are associated with carotid IMT in healthy Chinese Han subjects.
Heart | 2010
Xie Xiang; Ma Yitong; Yang Yining; Fu Zhenyan; Ma Xiang; Huang Ding; Li Xiaomei; Chen Bangdang; Liu Fen
Aim The relationship between alcohol consumption and carotid atherosclerosis had been reported in some epidemiologic studies. But the results were conflicting in different researches. In the present study, we investigated the association between alcohol intake and carotid atherosclerosis in Chinese Han, Uighur, and Hazakh population. Methods and Results The study population sample comprised 13 037 Chinese people (5277 Han, 4572 Uighur, and 3188 Hazakh) aged 35 years and over, who participated a Cardiovascular Risk Survey between June 2007 and September 2009. Daily alcohol consumption was determined by the number and frequency of alcoholic beverages consumed. The carotid artery parameters including common carotid artery intima-media thickness (CCA-IMT) and carotid plaques were measured using high-resolution B-mode ultrasonography. In Han or Hazakh, carotid IMT as a function of alcohol consumption was depicted as a J-shaped curve with a nadir for the alcohol intake category of 20 to 29.9 g/d; In Uighur, the similar curve with a nadir of 30 to 49.9 g/d was observed. For the prevalence of carotid plaques, we also observed the similar curves in Han and Hazakh but not in Uighur. After adjusted for the age, sex, blood pressure, body mass index, smoking, GLU, total cholesterol, HDL, and LDL, the J-shaped curves remain existence. Conclusions Our results indicated that moderate drinking is a protective factor for carotid atherosclerosis. But the definition of moderate drinking should be difference in Han, Uighur and Hazakh population.
Heart | 2010
Xie Xiang; Ma Yitong; Yang Yining; Huang Ding; Li Xiaomei; Ma Xiang; Chen Bangdang; Liu Fev
Aim A low ankle-to-brachial index (ABI) is a strong correlate of cardiovascular disease and subsequent mortality. The relationship between ABI and alcohol consumption remains unclear. Methods and Results Data are from the Cardiovascular Risk Survey (CRS), a multi-ethnical community-based study of 14 593 Chinese people (5749 Han, 4747 Uighur, and 4097 Hazakh) aged 35 years and over at baseline in June 2007 to March 2010. The relationship between alcohol intake and ABI were determined by use of analysis of covariance and multivariable regressions. In men, a linear correlation between alcohol consumption and ABI was found by one-factor analysis of variance (p<0.001); After adjusted for the age, sex, ethnicity, blood pressure, body mass index, smoking, GLU, total cholesterol, HDL, and LDL, the difference remains significant (p=0.007). The multivariate-adjusted OR for peripheral artery disease was significantly higher in men who consumed >60.0 g/d (OR=1.997, 95% CI 1.500 to 2.989) and was significantly lower in men who consumed 20.0–40.0 g/d compared with never drinking, respectively (p=0.01, p=0.027, respectively, data not shown). Neither ABI nor PAD was correlated with alcohol intake in women. Conclusions Our results indicated that in Chinese men, moderate drinking is a protective factor but heavier drinking is a risk factor for peripheral arteriosclerosis.
PLOS ONE | 2015
An Yong; Wang Yong-Tao; Ma Yitong; Wulasihan Muhuyati; Huang Ying; Adi Dilare; Yang Yining; Ma Xiang; Li Xiaomei; Xie Xiang; Huang Ding; Liu Fen; Chen Bangdang
PLOS ONE | 2015
An Yong; Wang Yong-Tao; Ma Yitong; Wulasihan Muhuyati; Huang Ying; Adi Dilare; Yang Yining; Ma Xiang; Li Xiaomei; Xie Xiang; Huang Ding; Liu Fen; Chen Bangdang
PLOS ONE | 2015
An Yong; Wang Yong-Tao; Ma Yitong; Wulasihan Muhuyati; Huang Ying; Adi Dilare; Yang Yining; Ma Xiang; Li Xiaomei; Xie Xiang; Huang Ding; Liu Fen; Chen Bangdang
PLOS ONE | 2015
An Yong; Wang Yong-Tao; Ma Yitong; Wulasihan Muhuyati; Huang Ying; Adi Dilare; Yang Yining; Ma Xiang; Li Xiaomei; Xie Xiang; Huang Ding; Liu Fen; Chen Bangdang