Huma Shareef

Anti-urease activity of Mimusops elengi Linn (Sapotaceae).

Aim: Mimusops elengi L. (Sapotaceae) commonly known as Bakul is a small to large evergreen tree found all over the different parts of the world. Literature survey showed no reports on the anti urease activity of the flowers and leaves of Mimusops elengi. The present study was therefore envisaged to evaluate the anti urease activity of the methanolic extracts (MFE and MLE) of M. elengi. Study Design: Assessment of anti urease activity and total phenolic contents. Methodology: For the determination of total phenolic content of M. elengi extracts (MFE and MLE) the reaction mixture contained 50% Folin-Ciocalteu reagent (0.5 mL), 20% (w/v) sodium carbonate solution (2.5 mL), and gallic acid solution (1, 2.5, 5, 10, 25, 50, 100 g/ml) or sample extracts (1.0 Original Research Article Zahid et al.; EJMP, 6(4): 223-230, 2015; Article no.EJMP.2015.058 224 mL). Urease inhibition activity was determined by mixing Urease (Jack bean) method was employed for urease inhibition activity. Results: From the standard calibration curve of gallic acid the total phenolic contents in extracts (MFE and MLE) was found to be 7.50.28 mg/g, 96.84.6 mg/g. Urease inhibitory activity of M. elengi extracts (MFE and MLE) was comparable with standard Thiourea. The percentage urease inhibition of Thiourea was found to be 98.2%, IC50 88.2 ± 0.01 g/ml. The maximum urease inhibitory activity was shown by the leaves extract (MLE) i. e, 77.9% (IC50 62.1±1.20 g/ml) while methanolic extract of flower (MFE) produced 47.6% urease inhibition activity. The total phenolic contents in both methanolic extracts (MFE and MLE) was found to be 7.50.28 mg/g, 96.84.6 mg/g respectively. Conclusion: It is, therefore, concluded that this plant can be a sources to isolate some natural urease inhibitory agents.

Medicinal Importance of Holoptelea Integrifolia (Roxb).Planch - Its Biological and Pharmacological Activities

Medicinal plants have assumed greater importance in the recent days, due to the tremendous potential they offer in formulating new drugs which afflict humankind against many diseases. During the past one century there had been a rapid growth of allopathic system of medical treatment in Pakistan and India. There is now a growing focus on the importance of medicinal plants and the traditional health systems in solving the healthcare problems of the world. Most developing countries have viewed traditional medical practice as an integral part of their culture. Medicinal plants have curative properties due to the presence of various complex chemical substances of different composition, which are found as secondary metabolites in one or more parts of the plants. These metabolites according to their chemical skeleton are grouped as alkaloids, glycosides, corticosteroids, essential oil, etc. Plants like Holoptelea integrifolia (Roxb.) Planch (Family: Ulmaceae), is gaining greater importance due to various pharmacological effects for example: analgesic, anti-inflammatory and antibacterial activities in the treatment of diseases. This plant contains a variety of chemical compounds that have been considered for the treatment of cancer of bladder, convulsions, inflammation, topical ulcers, rheumatic inflammation, fever and dysentery. In this article the pharmacognostic characteristics of Holoptelea integrifolia, its medicinal significance and pharmacological effects have been presented.

Genus Allium: The Potential Nutritive and Therapeutic Source

The two Allium species, Onion ( Allium cepa L.) and garlic ( Allium sativum L.) are the most edible and oldest cultivated plants. These two species have not only beneficial effects against disease also they have nutritive potential. They are very rich sources of several phytonutrients, electrolytes, carbohydrates, minerals, and vitamins and documented to have a significant identical pharmacological characteristic including hypocholestremic, hypotensive, hypoglycecmic, antithrombotic and anti allergic as well as wide range of biological activities such as anti-inflammatory, antimicrobial, antifungal and antioxidants. This review article will scan the nature with understanding, thinking, realizing and utilization of these two herbs for their therapeutic source in adding together their nutritive potential. In this review we focused on the nutritional attributes along with their curative potential of species of Allium genus (onion and garlic) belonging to the family Alliaceae. DOI: http://dx.doi.org/10.6000/1927-5951.2011.01.02.11