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Hwang-Fun Lu

G. D. Searle & Company

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Publication

Featured researches published by Hwang-Fun Lu.

Bioorganic & Medicinal Chemistry Letters | 1997

Replacements for lysine in l-seryl-l-lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase

David L. Brown; Balekudru Devadas; Hwang-Fun Lu; Srinivasan Nagarajan; Mark E. Zupec; Sandra K. Freeman; Charles A. McWherter; Daniel P. Getman; James A. Sikorski

Abstract A survey of potential cyclic and acyclic lysine replacements in known l -seryl- l -lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good selectivity over the human enzyme. All of the heterocyclic lysine mimetics that were examined exhibited dramatically weaker affinity with the fungal enzyme.

Official Gazette of the United States Patent and Trademark Office Patents | 2001

Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors

John J. Talley; James A. Sikorski; Matthew J. Graneto; Jeffery S Carter; Bryan H. Norman; Balekudru Devadas; Hwang-Fun Lu

Journal of Medicinal Chemistry | 1997

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.

Balekudru Devadas; Sandra K. Freeman; Mark E. Zupec; Hwang-Fun Lu; Srinivasan Nagarajan; Nandini S. Kishore; Jennifer K. Lodge; David W. Kuneman; Charles A. McWherter; Dutt V. Vinjamoori; Daniel P. Getman; and Jeffrey I. Gordon; James A. Sikorski

Biopolymers | 1997

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.

James A. Sikorski; Balekudru Devadas; Mark E. Zupec; Sandra K. Freeman; David L. Brown; Hwang-Fun Lu; Srinivasan Nagarajan; Pramod P. Mehta; Arlene C. Wade; Nandini S. Kishore; Martin L. Bryant; Daniel P. Getman; C A McWherter; Jeffrey I. Gordon

Journal of Medicinal Chemistry | 1997

Conformationally constrained [p-(ω-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase

Srinivasan Nagarajan; Balekudru Devadas; Mark E. Zupec; Sandra K. Freeman; David L. Brown; Hwang-Fun Lu; Pramod P. Mehta; Nandini S. Kishore; Charles A. McWherter; Daniel P. Getman; Jeffrey I. Gordon; James A. Sikorski

Archive | 1996

Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

James A. Sikorski; Daniel P. Getman; Gary A. DeCrescenzo; Balekudru Devadas; John N. Freskos; Hwang-Fun Lu; Joseph J. McDonald

Archive | 2001

Heteroarylalkanoic acids as integrin receptor antagonists

Scrinivasan Raj Nagarajan; Ish K. Khanna; Michael B. Tollefson; Scott B. Mohler; Barbara Chen; Mark A. Russell; Balekudru Devadas; Thomas D. Penning; Lori A. Schretzman; Dale P. Spangler; Mark L. Boys; Nizal S. Chandrakumar; Hwang-Fun Lu

Archive | 2001

Cycloalkyl alkanoic acids as integrin receptor antagonists

Ish Kurmar Khanna; Michael Clare; Alan F. Gasiecki; Thomas Edward Rogers; Barbara B. Chen; Mark A. Russell; Hwang-Fun Lu

Archive | 1999

Amino benzenepropanoic acid compounds and derivatives thereof

Joe T. Collins; Balekudru Devadas; Hwang-Fun Lu; James W. Malecha; Julie M. Miyashiro; Srinivasan Nagarajan; Joseph G. Rico; Thomas E. Rogers

Archive | 2003

R-isomer of beta amino acid compounds as integrin receptor antagonists derivatives

Thomas Edward Rogers; Peter G. Ruminski; Srinivasan Nagarajan; Balekudru Devadas; James W. Malecha; Lawrence M. Miller; Joseph G. Rico; Hwang-Fun Lu; Laura D. Marrufo; Joe T. Collins

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Balekudru Devadas

Washington University in St. Louis

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James A. Sikorski

Monsanto

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Thomas Edward Rogers

Monsanto

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Bryan H. Norman

Monsanto

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Jeffery S Carter

Pfizer

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Matthew J. Graneto

Monsanto

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Mark L. Boys

Pfizer

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Barbara B. Chen

Pfizer

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Bipinchandra Nanubhai Desai

Pfizer

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David L. Brown

Pfizer

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