Hwi-Gon Kim
Pusan National University
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Publication
Featured researches published by Hwi-Gon Kim.
PLOS ONE | 2014
Sang-Mo Kwon; J. Lee; Sang Hun Lee; Seok-Yun Jung; Da-Yeon Kim; Songhwa Kang; So Young Yoo; Jong-Kyu Hong; Ji Hye Park; Jung-Hee Kim; Sung-Wook Kim; Yeon-Ju Kim; Sun Jin Lee; Hwi-Gon Kim; Takayuki Asahara
Introduction Despite the crucial role of endothelial progenitor cells (EPCs) in vascular regeneration, the specific interactions between EPCs and hematopoietic cells remain unclear. Methods In EPC colony forming assays, we first demonstrated that the formation of EPC colonies was drastically increased in the coculture of CD34+ and CD34− cells, and determined the optimal concentrations of CD34+ cells and CD34− cells for spindle-shaped EPC differentiation. Results Functionally, the coculture of CD34+ and CD34− cells resulted in a significant enhancement of adhesion, tube formation, and migration capacity compared with culture of CD34+ cells alone. Furthermore, blood flow recovery and capillary formation were remarkably increased by the coculture of CD34+ and CD34− cells in a murine hind-limb ischemia model. To elucidate further the role of hematopoietic cells in EPC differentiation, we isolated different populations of hematopoietic cells. T lymphocytes (CD3+) markedly accelerated the early EPC status of CD34+ cells, while macrophages (CD11b+) or megakaryocytes (CD41+) specifically promoted large EPC colonies. Conclusion Our results suggest that specific populations of hematopoietic cells play a role in the EPC differentiation of CD34+ cells, a finding that may aid in the development of a novel cell therapy strategy to overcome the quantitative and qualitative limitations of EPC therapy.
Journal of Obstetrics and Gynaecology Research | 2012
Dong-Hyung Lee; Seung-Chul Kim; Jong-Kil Joo; Hwi-Gon Kim; Young-Jin Na; Jong-Young Kwak; Kyu-Sup Lee
Aim: Hormones and inflammation have been implicated in the pathological process of endometriosis; therefore, we investigated the combined effects of 17β‐estradiol (E2) and peritoneal fluid obtained from patients with endometriosis (ePF) or a control peritoneal fluid (cPF) obtained from patients without endometriosis on the release of monocyte chemotactic protein‐1 (MCP‐1) by monocytes and the role of signaling pathways.
Journal of Obstetrics and Gynaecology Research | 2010
Choong-Sik Ha; Bo-Sun Joo; Seung-Chul Kim; Jong-Kil Joo; Hwi-Gon Kim; Kyu-Sup Lee
Aims: This study investigated whether estrogen administration during superovulation enhances oocyte quality using a mice model. We also investigated whether this estrogen treatment regulates the expressions of angiogenic factors, such as vascular endothelial growth factor (VEGF) and endothelial nitric oxide synthase (eNOS), in the ovary.
Toxicology Letters | 2014
Hye Jin Choi; Hwi-Gon Kim; Juil Kim; Seong-Hwan Park; Jiyeon Park; Chang Gyu Oh; Kee Hun Do; Seung Joon Lee; Young Chul Park; Soon Cheol Ahn; Yong Sik Kim; Yuseok Moon
Carrageenan (CGN), a widely used food additive, has been shown to injure the epithelial barrier in animal models. This type of damage is a clinical feature of inflammatory bowel disease (IBD) in humans. In the present study, the effects of CGN on pro-apoptotic responses associated with macrophage inhibitory cytokine 1 (MIC-1) regulation in human enterocytes were evaluated. CGN up-regulated the expression of MIC-1 that promoted epithelial cell apoptosis. Although MIC-1 induction was dependent on pro-apoptotic p53 protein, the pro-survival protein activating transcription factor 3 (ATF3) was negatively regulated by p53 expression. However, MIC-1 enhanced the expression of the pro-survival protein ATF3 in enterocytes exposed to CGN. Functionally, MIC-1-mediated epithelial cell apoptosis was counteracted by the pro-survival action of ATF3 in response to CGN exposure. These findings demonstrated that the counterbalance between MIC-1 and ATF3 is critical for deciding the fate of enterocytes under the food chemical stress.
Journal of Menopausal Medicine | 2013
Hwi-Gon Kim; Yong Jung Song; Yong Jin Na; Ook-Hwan Choi
Primary vaginal cancer combined with uterine prolapse is very rare. We present a case of 80-year-old postmenopausal women complaints of something coming out per vagina for the past 20 years, along with blood stained discharge, foul odor leukorrhea, and severe pelvic pain for the last 3 months. A 4 × 5 cm ulcer was present on middle third of vaginal wall with marked edema and ulceration of surrounding tissue. The prolapse was reduced under intravenous sedation in operating room. On gynecologic examination, uterus was normal in size, no adnexal mass was examined, and both parametrium were thickened. Papanicolaou smear was normal. Biopsy of the ulcer at vaginal wall revealed invasive squamous cell carcinoma of vagina. Magnetic Resonance Imaging of abdomen and pelvis showed left hydronephrosis and liver metastasis. Positron emission tomography (PET)/computed tomography (CT) revealed metastasis to lung, liver and iliac bone. She died from progression of disease one month after diagnosis.
Clinical and Experimental Reproductive Medicine | 2018
Ju-Eun Jeong; Bo-Sun Joo; Chang-Woon Kim; Hwi-Gon Kim; Jong-Kil Joo; Kyu-Sup Lee
Objective This study conducted a preliminary examination of the effects of three-area laser-assisted zona thinning (LAZT) during the cleavage stage of embryo development on the hatching process in human in vitro fertilization-embryo transfer (IVF-ET) with subjects of advanced female age or frozen-thawed (FT) embryos. Methods Eight-cell stage embryos were treated with LAZT in three areas of the zona pellucida at 120° intervals. The control group was embryos without LAZT. Of the 72 consecutive fresh cycles and the 28 FT embryo transfer cycles, the patients in 55 fresh cycles and 17 FT cycles declined LAZT, and those cycles were defined as the control group. Results In the fresh cycles, the pregnancy rates were similar in the LAZT and control groups. However, in the FT cycles, the pregnancy rate was significantly higher in the LAZT group than in the control group (45.5% in the LAZT group vs. 23.5% in the control group, p<0.05). Conclusion These results show that multi-area LAZT resulted in significantly improved pregnancy outcomes in human 8-cell embryos compared to controls.
Journal of Menopausal Medicine | 2013
Hwi-Gon Kim; Yong Jung Song; Yong Jin Na; Ook-Hwan Choi
Adenoid basal carcinoma of the uterine cervix is uncommon neoplasia mostly occurring in postmenopausal women. It has excellent prognosis and a favorable clinical course. In addition, adenoid basal carcinoma is differentiated from adenoid cystic carcinoma by histologic and cellular morphologies, and immunohistochemistry. In this paper, we present the case of a 22 year old Korean female. She initially had a high-grade squamous intraepithelial lesion (HSIL) on Pap smear and a subsequent cervical loop electrosurgical excision procedure (LEEP) specimen revealing adenoid basal carcinoma. The lesion showed the histologic characteristics of adenoid basal carcinoma. Because of the lesions low potential for recurrence and metastasis, the young primipara had a conization procedure performed and has been under close observation.
Obstetrics & gynecology science | 2007
Hoo-Hyung Lee; Hwi-Gon Kim; Sung-Kyoo Jang; Ook-Hwan Choi
The Journal of Korean Society of Menopause | 2013
Jae-Heok Jeong; Hwi-Gon Kim; Ki-Hyung Kim; Ook-Hwan Choi
Obstetrics & gynecology science | 2010
Soo-Hyeon Moon; Seong-Eui Lee; Hwi-Gon Kim; Ook-Hwan Choi; Kyu-Sup Lee; Yong-Jin Na