Hyeong-n Ji
Chungbuk National University
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Publication
Featured researches published by Hyeong-n Ji.
Reproductive Toxicology | 2009
Dongsun Park; Jeong Hee Jeon; Sunhee Shin; Seong Soo Joo; Dae-Hyuck Kang; Seol-Hee Moon; Min-Jung Jang; Yeoung Mi Cho; Jae Wook Kim; Hyeong-Jin Ji; Byeongwoo Ahn; Ki-Wan Oh; Yun-Bae Kim
The effects of green tea extract (GTE) on the fetal development and external, visceral and skeletal abnormalities induced by cyclophosphamide were investigated in rats. Pregnant rats were daily administered GTE (100mg/kg) by gavage for 7 d, from the 6th to 12th day of gestation, and intraperitoneally administered with cyclophosphamide (11mg/kg) 1h after the final treatment. On the 20th day of gestation, maternal and fetal abnormalities were determined by Cesarian section. Cyclophosphamide was found to reduce fetal and placental weights without increasing resorption or death. In addition, it induced malformations in live fetuses; 94.6%, 41.5% and 100% of the external (skull and limb defects), visceral (cleft palate and ureteric dilatation) and skeletal (acrania, vertebral/costal malformations and delayed ossification) abnormalities. When pre-treated with GTE, cyclophosphamide-induced body weight loss and abnormalities of fetuses were remarkably aggravated. Moreover, repeated treatment with GTE greatly increased mRNA expression and activity of hepatic cytochrome P-450 (CYP) 2B, which metabolizes cyclophosphamide into teratogenic acrolein and cytotoxic phosphoramide mustard, while reducing CYP3A expression (a detoxifying enzyme). The results suggest that repeated intake of GTE may aggravate cyclophosphamide-induced body weight loss and malformations of fetuses by modulating CYP2B and CYP3A.
Nutrients | 2015
Yang Hee Jo; Kyeong-Mi Choi; Qing Liu; Seon Beom Kim; Hyeong-Jin Ji; Myoung Hwan Kim; Sang-Kyung Shin; Seon-Gil Do; Eunju Shin; Gayoung Jung; Hwan-Soo Yoo; Bang Yeon Hwang; Mi Kyeong Lee
Obesity, which is characterized by excessive fat accumulation, is associated with several pathological disorders, including metabolic diseases. In this study, the anti-obesity effect of 6,8-diprenylgenistein (DPG), a major isoflavonoid of Cudrania tricuspidata fruits was investigated using high fat-diet (HFD)-induced obese mice at the doses of 10 and 30 mg/kg for six week. The body weight of the DPG-treated groups was significantly lower compared to the HFD-treated group. In addition, fat accumulation in epididymal adipose tissue and liver was dramatically decreased in the HFD + DPG groups. The food efficiency ratios of the HFD + DPG groups were also lower compared to the HFD group with the same food intake. Metabolic parameters that had increased in the HFD group were decreased in the HFD + DPG groups. Further studies demonstrate that DPG efficiently reduces lipogenic genes by regulation of transcription factors, such as peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer-binding protein α (C/EBPα), and hormones, such as leptin and adiponection. DPG also regulates acetyl-CoA carboxylase (ACC) and hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) by AMP-activated protein kinase (AMPK) activation. Taken together, DPG is beneficial for the regulation of obesity, especially resulting from high fat intake.
Journal of Ethnopharmacology | 2014
Seon Beom Kim; Byeongwoo Ahn; Myoung Hwan Kim; Hyeong-Jin Ji; Sang-Kyung Shin; In Pyo Hong; Chul Young Kim; Bang Yeon Hwang; Mi Kyeong Lee
Laboratory Animal Research | 2006
Sunhee Shin; Ja Young Jang; Byong-il Choi; Jeong Hee Jeon; Hyeong-Jin Ji; Seol Hee Moon; Dong-Hyun Jung; Yeoung-Gil Yeo; Sung-Jin Baek; Seok-Yeon Hwang; Jae-Hyun Chung; Yun-Bae Kim
Laboratory Animal Research | 2008
Jwa Jin Kim; Chang Whan Kim; Dongsun Park; Sunhee Shin; Jeong Hee Jeon; Min-Jung Jang; Hyeong-Jin Ji; Namgil O; Jugyeong Song; Jinsoo Lee; Byung-Yul Kim; Ehn-Kyoung Choi; Seong Soo Joo; Seock-Yeon Hwang; Yun-Bae Kim
European Journal of Pharmacology | 2007
Hyeong-Jin Ji; Hee-Youl Chai; Sang-Soep Nahm; Junhee Lee; Gun Won Bae; Kwang Nho; Yun-Bae Kim; Jong-Koo Kang
Biomaterials | 2015
Kwon Pyo Hong; Mi Hyang Shin; Sangsoon Yoon; Gil Yong Ji; Yoo Ri Moon; Ok-Jun Lee; Song-Yi Choi; Yong-Moon Lee; Ji Hae Koo; Ho-chang Lee; Geon Kook Lee; Seung Ryul Kim; Ki Hyeong Lee; Hye-Suk Han; Kang Hyeon Choe; Ki Man Lee; Jong-Myeon Hong; Si-Wook Kim; Jae Hyuk Yi; Hyeong-Jin Ji; Yun-Bae Kim; Hyung Geun Song
Laboratory Animal Research | 2007
Yeoung Mi Cho; Sunhee Shin; Dongsun Park; Jeong Hee Jeon; Min-Jung Jang; Jwa Jin Kim; Jae Wook Kim; Hyeong-Jin Ji; Chang Hwan Kim; Seongjin Baek; Seok-Yeon Hwang; Gonhyung Kim; Yun-Bae Kim
Journal of the Preventive Veterinary Medicine | 2015
Jung Su Lee; Hyeong-Jin Ji; Hee-Youl Chai; Jae-Hwang Jeong; Sang-Yoon Nam; Young Won Yun; Beom Jun Lee
Journal of the Preventive Veterinary Medicine | 2015
Jung Su Lee; Hyeong-Jin Ji; Hee-Youl Chai; Jae-Hwang Jeong; Sang-Yoon Nam; Young Won Yun; Beom Jun Lee