Hyun-Suk Kang

Climate change in the 21st century simulated by HadGEM2-AO under representative concentration pathways

We present climate responses of Representative Concentration Pathways (RCPs) using the coupled climate model HadGEM2-AO for the Coupled Model Intercomparison Project phase 5 (CMIP5). The RCPs are selected as standard scenarios for the IPCC Fifth Assessment Report and these scenarios include time paths for emissions and concentrations of greenhouse gas and aerosols and land-use/land cover. The global average warming and precipitation increases for the last 20 years of the 21st century relative to the period 1986-2005 are +1.1°C/+2.1% for RCP2.6, +2.4°C/+4.0% for RCP4.5, +2.5°C/+3.3% for RCP6.0 and +4.1°C/+4.6% for RCP8.5, respectively. The climate response on RCP 2.6 scenario meets the UN Copenhagen Accord to limit global warming within two degrees at the end of 21st century, the mitigation effect is about 3°C between RCP2.6 and RCP8.5. The projected precipitation changes over the 21st century are expected to increase in tropical regions and at high latitudes, and decrease in subtropical regions associated with projected poleward expansions of the Hadley cell. Total soil moisture change is projected to decrease in northern hemisphere high latitudes and increase in central Africa and Asia whereas near-surface soil moisture tends to decrease in most areas according to the warming and evaporation increase. The trend and magnitude of future climate extremes are also projected to increase in proportion to radiative forcing of RCPs. For RCP 8.5, at the end of the summer season the Arctic is projected to be free of sea ice.

Developmental hemispheric asymmetry of interregional metabolic correlation of the auditory cortex in deaf subjects

The functional connectivity of the auditory cortex might be altered in deaf subjects due to the loss of auditory input. We studied the developmental changes of functional connectivity of the primary auditory cortex (A1) in deaf children, deaf adults, and normal hearing adults by examining interregional metabolic correlation with (18)F-FDG PET. The mean activity of FDG uptake in the cytoarchitectonically defined A1 region served as a covariate in the interregional and interhemispheric correlation analysis. A1 metabolic rate was correlated with that of the ipsilateral superior temporal lobe in both normal and deaf subjects. This correlated area was larger in deaf children than in deaf or normal hearing adults. Concerning the functional connectivity of A1, a hemispheric asymmetry was found in that the extent of interregional correlation was clearly larger in the right than in the left hemisphere. This asymmetry was particularly pronounced in the younger deaf children. Both extent and asymmetry of the functional connectivity of A1 subsided with age. Contrary to this, a correlation between the left and the right primary auditory cortices was absent in younger deaf children but became apparent as they grew older.

Evaluation of multiple regional climate models for summer climate extremes over East Asia

In this study, five regional climate models (RCMs) participating in the CORDEX-East Asia project (HadGEM3-RA, RegCM4, SNU-MM5, SNU-WRF, and YSU-RSM) are evaluated in terms of their performances in simulating the climatology of summer extremes in East Asia. Seasonal maxima of daily mean temperature and precipitation are analyzed using the generalized extreme value method. RCMs show systematic bias patterns in both seasonal means and extremes. A cold bias is located along the coast, whereas a warm bias occurs in northern China. Overall, wet bias occurs in East Asia, but with a substantial dry bias centered in South Korea. This dry bias appears to be related to the colder ocean surface around South Korea, positioning the monsoonal front further south compared to observations. Taylor diagram analyses reveal that the models simulate temperature means more accurately compared to extremes because of the higher spatial correlation, whereas precipitation extremes are simulated better than their means because of the higher spatial variability. The latter implies that extreme rainfall events can be captured more accurately by RCMs compared to the driving GCM despite poorer simulation of mean rainfall. Inter-RCM analysis indicates a close relationship between the means and extremes in terms of model skills, but it does not show a clear relationship between temperature and precipitation. Sub-regional analysis largely supports the mean–extreme skill relationship. Analyses of frequency and intensity distributions of daily data for three selected sub-regions suggest that overall shifts of temperature distribution and biases in moderate–heavy precipitations contribute importantly to the seasonal mean biases.

Prediction of the Arctic Oscillation in boreal winter by dynamical seasonal forecasting systems

This study assesses the skill of boreal winter Arctic Oscillation (AO) predictions with state-of-the-art dynamical ensemble prediction systems (EPSs): GloSea4, CFSv2, GEOS-5, CanCM3, CanCM4, and CM2.1. Long-term reforecasts with the EPSs are used to evaluate how well they represent the AO and to assess the skill of both deterministic and probabilistic forecasts of the AO. The reforecasts reproduce the observed changes in the large-scale patterns of the Northern Hemispheric surface temperature, upper level wind, and precipitation associated with the different phases of the AO. The results demonstrate that most EPSs improve upon persistence skill scores for lead times up to 2 months in boreal winter, suggesting some potential for skillful prediction of the AO and its associated climate anomalies at seasonal time scales. It is also found that the skill of AO forecasts during the recent period (1997–2010) is higher than that of the earlier period (1983–1996).

Projections of high resolution climate changes for South Korea using multiple-regional climate models based on four RCP scenarios. Part 1: surface air temperature

We projected surface air temperature changes over South Korea during the mid (2026-2050) and late (2076-2100) 21st century against the current climate (1981-2005) using the simulation results from five regional climate models (RCMs) driven by Hadley Centre Global Environmental Model, version 2, coupled with the Atmosphere- Ocean (HadGEM2-AO), and two ensemble methods (equal weighted averaging, weighted averaging based on Taylor’s skill score) under four Representative Concentration Pathways (RCP) scenarios. In general, the five RCM ensembles captured the spatial and seasonal variations, and probability distribution of temperature over South Korea reasonably compared to observation. They particularly showed a good performance in simulating annual temperature range compared to HadGEM2-AO. In future simulation, the temperature over South Korea will increase significantly for all scenarios and seasons. Stronger warming trends are projected in the late 21st century than in the mid-21st century, in particular under RCP8.5. The five RCM ensembles projected that temperature changes for the mid/late 21st century relative to the current climate are +1.54°C/+1.92°C for RCP2.6, +1.68°C/+2.91°C for RCP4.5, +1.17°C/+3.11°C for RCP6.0, and +1.75°C/+4.73°C for RCP8.5. Compared to the temperature projection of HadGEM2-AO, the five RCM ensembles projected smaller increases in temperature for all RCP scenarios and seasons. The inter-RCM spread is proportional to the simulation period (i.e., larger in the late-21st than mid-21st century) and significantly greater (about four times) in winter than summer for all RCP scenarios. Therefore, the modeled predictions of temperature increases during the late 21st century, particularly for winter temperatures, should be used with caution.

Changes of precipitation extremes over South Korea projected by the 5 RCMs under RCP scenarios

The change of extreme precipitation is assessed with the HadGEM2-AO - 5 Regional Climate Models (RCMs) chain, which is a national downscaling project undertaken cooperatively by several South Korean institutes aimed at producing regional climate change projection with fine resolution (12.5 km) around the Korean Peninsula. The downscaling domain, resolution and lateral boundary conditions are held the same among the 5 RCMs to minimize the uncertainties from model configuration. Climatological changes reveal a statistically significant increase in the mid-21st century (2046- 2070; Fut1) and the late-21st century (2076-2100; Fut2) precipitation properties related to extreme precipitation, such as precipitation intensity and average of upper 5 percentile daily precipitation, with respect to the reference period (1981-2005). Changes depending on the intensity categories also present a clear trend of decreasing light rain and increasing heavy rain. In accordance with these results, the change of 1-in-50 year maximum precipitation intensity over South Korea is estimated by the GEV method. The result suggests that the 50-year return value (RV50) will change from -32.69% to 72.7% and from -31.6% to 96.32% in Fut1 and from -31.97% to 86.25% and from -19.45% to 134.88% in Fut2 under representative concentration pathway (RCP) 4.5 and 8.5 scenarios, respectively, at the 90% confidence level. This study suggests that multi-RCMs can be used to reduce uncertainties and assess the future change of extreme precipitation more reliably. Moreover, future projection of the regional climate change contains uncertainties evoked from not only driving GCM but also RCM. Therefore, multi-GCM and multi-RCM studies are expected to provide more robust projection.

Projections of high resolution climate changes for South Korea using multiple-regional climate models based on four RCP scenarios. Part 2: precipitation

Precipitation changes over South Korea were projected using five regional climate models (RCMs) with a horizontal resolution of 12.5 km for the mid and late 21st century (2026-2050, 2076- 2100) under four Representative Concentration Pathways (RCP) scenarios against present precipitation (1981-2005). The simulation data of the Hadley Centre Global Environmental Model version 2 coupled with the Atmosphere-Ocean (HadGEM2-AO) was used as boundary data of RCMs. In general, the RCMs well simulated the spatial and seasonal variations of present precipitation compared with observation and HadGEM2-AO. Equal Weighted Averaging without Bias Correction (EWA_NBC) significantly reduced the model biases to some extent, but systematic biases in results still remained. However, the Weighted Averaging based on Taylor’s skill score (WEA_Tay) showed a good statistical correction in terms of the spatial and seasonal variations, the magnitude of precipitation amount, and the probability density. In the mid-21st century, the spatial and interannual variabilities of precipitation over South Korea are projected to increase regardless of the RCP scenarios and seasons. However, the changes in area-averaged seasonal precipitation are not significant due to mixed changing patterns depending on locations. Whereas, in the late 21st century, the precipitation is projected to increase proportionally to the changes of net radiative forcing. Under RCP8.5, WEA_Tay projects the precipitation to be increased by about +19.1, +20.5, +33.3% for annual, summer and winter precipitation at 1-5% significance levels, respectively. In addition, the probability of strong precipitation (≥ 15 mm d-1) is also projected to increase significantly, particularly in WEA_Tay under RCP8.5.

Time of emergence of anthropogenic warming signals in the Northeast Asia assessed from multi-regional climate models

Time of Emergence (ToE) is the time at which the signal of climate change emerges from the background noise of natural climate variability, and can provide useful information for climate change impacts and adaptations. This study examines future ToEs for daily maximum and minimum temperatures over the Northeast Asia using five Regional Climate Models (RCMs) simulations driven by single Global Climate Model (GCM) under two Representative Concentration Pathways (RCP) emission scenarios. Noise is defined based on the interannual variability during the present-day period (1981-2010) and warming signals in the future years (2021-2100) are compared against the noise in order to identify ToEs. Results show that ToEs of annual mean temperatures occur between 2030s and 2040s in RCMs, which essentially follow those of the driving GCM. This represents the dominant influence of GCM boundary forcing on RCM results in this region. ToEs of seasonal temperatures exhibit larger ranges from 2030s to 2090s. The seasonality of ToE is found to be determined majorly by noise amplitudes. The earliest ToE appears in autumn when the noise is smallest while the latest ToE occurs in winter when the noise is largest. The RCP4.5 scenario exhibits later emergence years than the RCP8.5 scenario by 5-35 years. The significant delay in ToEs by taking the lower emission scenario provides an important implication for climate change mitigation. Daily minimum temperatures tend to have earlier emergence than daily maximum temperature but with low confidence. It is also found that noise thresholds can strongly affect ToE years, i.e. larger noise threshold induces later emergence, indicating the importance of noise estimation in the ToE assessment.

Inhibition of nitric oxide synthesis increases apoptotic cardiomyocyte death and myocardial angiotensin-converting enzyme gene expression in ischemia/reperfusion-injured myocardium of rats

Abstract Cardiomyocyte apoptosis is an important pathogenic mechanism in myocardial ischemia/reperfusion (I/R) injury. It has been shown that nitric oxide (NO) and the renin–angiotensin system (RAS) are closely related, and both systems regulate apoptotic cell death. However, the effects of NO modulation on myocardial apoptotic cell death and changes in the RAS in the I/R-injured myocardium have not been studied. Female Sprague–Dawley rats were randomized into three groups: NO synthesis inhibitor, NG-nitro-l-arginine-methyl ester (l-NAME, 10 mg/kg); NO precursor, l-arginine (540 mg/kg); and vehicle. The rats were then subjected to 45 min coronary occlusion followed by 4 h reperfusion. The TdT-mediated in situ nick and labeling (TUNEL) indices were 39.9% ± 0.8% at the border and 30.9% ± 1.2% at the center of the I/R area in the vehicle group. L-NAME administration significantly increased these TUNEL-positive cells to 45.3% ± 1.9% and 37.9% ± 1.3%, respectively (P < 0.05 each). L-arginine administration reduced the TUNEL index at the border zone with marginal significance (P = 0.08 vs vehicle group). I/R injury significantly reduced the angiotensin-converting enzyme (ACE) mRNA expression in the left (ventricular) free wall of vehicle group rats. However, ACE mRNA expression was 1.9 times greater in the L-NAME group than that in the vehicle group (P < 0.05). This study showed that the inhibition of NO synthesis increased apoptotic cardiomyocyte death and local ACE mRNA expression in the I/R-injured myocardium. Our observations indicate that NO, ACE, and apoptotic cardiomyocyte death are related to each other during I/R injury.

Half‐dose ganciclovir preemptive treatment of cytomegalovirus infection after pediatric allogeneic hematopoietic stem cell transplantation

Ganciclovir (GCV) has been widely used as preemptive therapy after hematopoietic stem cell transplantation (HSCT), although bone marrow suppression is a known accompaniment, with secondary infection or bleeding as potential complications. Our aim was to evaluate clinical outcomes in pediatric patients with low cytomegalovirus (CMV) antigenemia levels using half the dosage of GCV generally given preemptively.