Hyung-Jin Yoo
Harvard University
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Featured researches published by Hyung-Jin Yoo.
Journal of Vascular Surgery | 2010
Jeanwan Kang; Hassan Albadawi; Patrick Casey; Thomas A. Abbruzzese; Virendra I. Patel; Hyung-Jin Yoo; Richard P. Cambria; Michael T. Watkins
INTRODUCTION Hypothermia is widely used to mediate ischemia-reperfusion injury associated with repair of the thoracoabdominal aorta. Experiments were designed in a murine model of thoracic aortic ischemia-reperfusion (TAR) to evaluate the effect of moderate systemic hypothermia on neurologic function, spinal cord morphology, and indices of inflammation in critical organs. METHODS C57BL/6 mice were subjected to TAR under hypothermic (34 degrees C) or normothermic (38 degrees C) conditions, followed by 24 or 48 hours of normothermic reperfusion. Neurologic functions were assessed during reperfusion. Spinal cords were examined at 24 and 48 hours after reperfusion, and the degree of injury qualified by counting the number of viable motor neurons within the anterior horns. Keratinocyte chemokine, interleukin-6, and myeloperoxidase levels were measured from lung, liver, and kidney at 24 and 48 hours. RESULTS Normothermic TAR resulted in a dense neurologic deficit in all mice throughout the reperfusion period. Mice subjected to TAR under hypothermic conditions had transient, mild neurologic deficit during the initial periods of reperfusion. Between 24 and 48 hours, delayed paralysis developed in half of these mice, whereas the other half remained neurologically intact. Spinal cord histology showed a graded degree of injury that correlated with neurologic function. There was no correlation between markers of inflammation in various organs and neurologic outcomes following TAR. CONCLUSION Systemic moderate hypothermia was protective against immediate paralysis after TAR in all cases and was associated with delayed paralysis in 50% of mice. This study suggests that delayed-onset paralysis may be the result of a local insult, rather than a systemic inflammatory event, precipitating spinal cord injury.
Surgery | 2010
Robert S. Crawford; Hassan Albadawi; Marvin D. Atkins; John E. Jones; Hyung-Jin Yoo; Mark F. Conrad; W. Gerald Austen; Michael T. Watkins
BACKGROUND Several experiments were designed to determine whether the systemic, postischemic administration of PJ34,which is a poly-adenosine diphosphate (ADP)-ribose polymerase inhibitor, decreased tissue injury and inflammation after hind-limb ischemia reperfusion (I/R). METHODS C57BL6 mouse limbs were subjected to 1.5 h ischemia followed by 24-h reperfusion. The treatment group (PJ) received intraperitoneal PJ34 (30 mg/kg) immediately before reperfusion, as well as 15 min and 2 h into reperfusion. The control group (CG) received lactated Ringers alone at the same time intervals as PJ34 administration. The skeletal muscle levels of adenosine triphosphate (ATP), macrophage inflammatory protein-2 (MIP-2), keratinocyte derived chemokine (KC), and myeloperoxidase (MPO) were measured. Quantitative measurement of skeletal muscle tissue injury was assessed by microscopic analysis of fiber injury. RESULTS ATP levels were higher in limbs of PJ versus CG mice (absolute ATP: 4.7 +/- 0.35 vs 2.3 +/- 0.15-ng/mg tissue, P = .002). The levels of MIP-2, KC, and MPO were lower in PJ versus CG mice (MIP-2: 1.4 +/- 0.34 vs 3.67 +/- 0.67-pg/mg protein, P = .014; KC: 4.97 +/- 0.97 vs 12.65 +/- 3.05-pg/mg protein, P = .037; MPO: 46.27 +/- 10.53 vs 107.34 +/- 13.58-ng/mg protein, P = .008). Muscle fiber injury was markedly reduced in PJ versus CG mice (4.25 +/- 1.9% vs 22.68 +/- 3.0% total fibers, P = .0004). CONCLUSION Systemic postischemic administration of PJ34 preserved skeletal muscle energy levels, decreased inflammatory markers, and preserved tissue viability post-I/R. These results support PARP inhibition as a viable treatment for skeletal muscle I/R in a clinically relevant post hoc scenario.
American Journal of Surgery | 2012
Rajendra Patel; Hassan Albadawi; Wolfgang Steudel; Faraz F. Hashmi; Jeanwan Kang; Hyung-Jin Yoo; Michael T. Watkins
Journal of The American College of Surgeons | 2012
Valy Boulom; Chandler A. Long; Junaid Y. Malek; Hyung-Jin Yoo; Rahmi Oklu; Maxime Raux; Michael T. Watkins; Hassan Albadawi
Journal of Surgical Research | 2016
Hassan Albadawi; A. Aria Tzika; Christian Rask-Madsen; Lindsey M. Crowley; Michael W. Koulopoulos; Hyung-Jin Yoo; Michael T. Watkins
Journal of Vascular and Interventional Radiology | 2013
Rahmi Oklu; Hassan Albadawi; Hyung-Jin Yoo; Michael T. Watkins
Arteriosclerosis, Thrombosis, and Vascular Biology | 2013
Hassan Albadawi; Rahmi Oklu; Rita Malley; Hyung-Jin Yoo; Austen Wg; Michael T. Watkins
Journal of Surgical Research | 2012
Shirling Tsai; Rahmi Oklu; Hyung-Jin Yoo; J. Martyn; Austen Wg; Michael T. Watkins; Hassan Albadawi
Journal of Vascular Surgery | 2011
Shirling Tsai; Chandler A. Long; Hyung-Jin Yoo; Rahmi Oklu; Michael T. Watkins; Hassan Albadawi
Journal of Surgical Research | 2011
Mounir J. Haurani; Hassan Albadawi; Rabih Houbballah; J.P. Trubiano; P.J. Laub; Hyung-Jin Yoo; Michael T. Watkins