I. Gomez-Morilla

Freestanding waveguides in silicon

Using a direct-write process for the production of three dimensional microstructures on a semiconductor, freestanding waveguides have been realized in silicon. The waveguides are produced by a focused beam of high energy protons that is scanned over a silicon substrate. The latent image of the scan is subsequently developed by electrochemical etching. Herein the authors report on the fabrication method as well as determining the propagation loss of these structures. Propagation loss values of 13.4 and 14.6 dB/cm were obtained for these preliminary structures for transverse electric and transverse magnetic polarizations, respectively.

An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells

In humans and other mammals, it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the formation of amorphous magnesium-substituted calcium phosphate nanoparticles that trap soluble macromolecules, such as bacterial peptidoglycan and orally-fed protein antigens, in the lumen and transport them to immune cells of the intestinal tissue. The macromolecule-containing nanoparticles utilize epithelial M cells to enter Peyer’s patches - small areas of the intestine concentrated with particle-scavenging immune cells. In wild type mice, intestinal immune cells containing these naturally-formed nanoparticles expressed the immune tolerance-associated molecule ‘programmed death-ligand 1 (PD-L1)’, whereas in NOD1/2 double knock-out mice, which cannot recognize peptidoglycan, PD-L1 was undetected. Our results explain a role for constitutively formed calcium phosphate nanoparticles in the gut lumen and how this helps to shape intestinal immune homeostasis.

Micropatterning of Foturan photosensitive glass following exposure to MeV proton beams

A new proton lithography mechanism has been identified and investigated: the micropatterning of photosensitive etchable glass based on the crystallization of the glass after irradiation with MeV protons and heat treatment. The use of MeV protons results in a significantly reduced minimum feature size compared with reported results using ultraviolet (UV) irradiation and the threshold dose for etching is very low (4000 protons µm−2), offering the potential for creating complex microstructures by direct writing using very short exposures. The depth of the structures is determined only by the range of the protons in the glass, which allows structures with different depths to be fabricated. This technique appears to be very valuable for the rapid fabrication of high aspect ratio microstructures such as fluid networks and micro-optical devices in a material with useful optical and mechanical properties.

Rapid deep micromachining of polytetrafluoroethylene by MeV ion bombardment in oxygen-rich atmospheres

Polytetrafluoroethylene (PTFE) displays an unusual behaviour when exposed to energetic light ions. Whereas other polymers tend to go black and degrade when exposed to MeV proton beams in air, rapid ablation of PTFE is observed. This rapid direct etching of PTFE with protons was investigated in a series of experiments and it was found that the presence of oxygen was required to obtain the high etch rates observed. The phenomenon described here offers a mechanism for fabricating high aspect ratio PTFE microstructures.

Adsorption and diffusion of strontium in simulated rock fractures quantified via ion beam analysis

Abstract An experimental technique has been developed and applied to the problem of determining effective diffusion coefficients and partition coefficients of Sr in low permeability geological materials. This technique, the micro-reactor simulated channel method (MRSC), allows rapid determination of contaminant transport parameters with resulting values comparable to those determined by more traditional methods and also creates product surfaces that are amenable for direct chemical analysis. An attempt to further constrain mass flux was completed by detailed ion beam analysis of polished tuff surfaces (tuff is a polycrystalline polyminerallic aggregate dominated by silicate phases) that had been reacted with Sr solutions at concentrations of 10-5, 10-3 and 10-1 mol 1-1. Ion beam analysis was carried out using beams of both protons (using particle induced X-ray emission and elastic backscattering spectrometry or EBS) and alpha-particles (using Rutherford backscattering spectrometry). The ion beam analyses showed that increased solution concentrations resulted in increased surface concentrations and that in the highest concentration experiment, Sr penetrated to at least 4 μm below the primary interface. The Sr surface concentrations determined by EBS were 0.06 (±0.05), 0.87 (±0.30) and 2.40 (±1.0) atomic weight % in the experiments with starting solution concentrations of 10-5, 10-3, and 10-1 mol 1-1, respectively.