In Sun Park

Transmembrane protein 173 inhibits RANKL-induced osteoclast differentiation

Tmem173 was identified as a growth inhibitor associated with major histocompatibility complex (MHC) class II and a potential stimulator for IFN‐β, an innate immune inducer and a negative feedback controller for RANKL‐induced osteoclast differentiation of monocytic macrophage cells. In this study, we confirmed that transmembrane protein 173 (Tmem173) overexpression inhibited the expression of osteoclast‐specific genes, tartrate‐resistant acid phosphatase (TRAP), cathepsin K, and matrix metalloproteinase‐9 (MMP‐9), as well as bone resorption pit formation in RANKL‐treated RAW 264.7 cells. Activation of osteoclast‐specific transcription factors, c‐Fos and nuclear factor of activated T cells cytoplasmic‐1 (NFATc1), and RANKL‐induced activation of ERK were also down‐regulated by Tmem173 overexpression. Collectively, these results suggest that Tmem173 plays a regulatory role in RANKL–RANK‐mediated signaling in osteoclastogenesis.

The Effects of Sea Cucumber as an Anti-gastritis, Anti-gastric Ulcer, and Anti-Helicobater

Sea cucumber, , is used not only as an outstanding tonic food but also as a traditional medicine for the treatment of asthma, hypertension, rheumatism, anemia, and sinus congestion. The purpose of this study was to examine sea cucumber as an anti-gastritis and anti-gastric ulcer in HCl-ethanol-induced gastric and -infected animal models. Thirty 7-week-old SD rats and Mongolian gerbils were divided into normal (Nor, n

The medicinal mushroom Auricularia auricula-judae (Bull.) extract has antioxidant activity and promotes procollagen biosynthesis in HaCaT cells

Abstract In this study, Auricularia auricula-judae (Bull.) extract (AAE) had potent antioxidant activity in vitro and promoted the biosynthesis of procollagen, a precursor of collagen in HaCaT cells. In addition, the expression of HAS-3 (hyaluronic acid synthase), which is a moisturizing factor, was increased in HaCaT cells in response to AAE. Therefore, this work suggests that AAE has the potential to exhibit antioxidant activity and promote procollagen biosynthesis in HaCaT cells.