Irit Avivi
Rappaport Faculty of Medicine
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Publication
Featured researches published by Irit Avivi.
Leukemia & Lymphoma | 2014
Irit Avivi; Tsila Zuckerman; Norberto Krivoy; Edna Efrati
Abstract Methotrexate (MTX), a folate antagonist employed for treating a wide range of malignancies, has an extensive interpatient variability, resulting in unpredictable toxicity. The present study evaluated the impact of single gene polymorphisms (SNPs: rs1801133 and rs1801131 in the MTHFR gene; rs4149056 and rs11045879 in the SLC01B1 gene; and rs2032582 and rs1045642 in the ABCB1 transporter gene) on MTX blood levels and toxicity in samples from 69 patients with diffuse large-B-cell lymphoma (DLBCL) treated with high dose intravenous (HD IV) MTX, > 2 g/m2. None of the studied genotypes was found to be associated with a statistically significant risk for elevated MTX levels at 24–48 h after completing therapy with MTX. Ancestral alleles (T) for SLC01B1 rs4149056 (T521C) and SLC01B1 rs11045879 (intron C21273886T) were found to be associated with an increased risk for MTX-related toxicity (p < 0.05 and p = 0.07, respectively), emphasizing the potential importance of employing pharmacogenetic assessment for personalized medicine.
Blood | 2010
Avichai Shimoni; Irit Avivi; Jacob M. Rowe; Moshe Yeshurun; Itai Levi; Reuven Or; Paulina Patachenko; Abraham Avigdor; Tzila Zwas; Arnon Nagler
Blood | 2012
Sascha Dietrich; Herve Finel; Ariane Boumendil; Irit Avivi; Liisa Volin; Jan J. Cornelissen; Jan Walewski; Christoph Schmid; Theo de Witte; Harry C. Schouten; Martin Kaufmann; Catherine Sebban; Marek Trneny; Guido Kobbe; Philippe Guardiola; Johannes Schetelig; Michael Pfreundschuh; Jose L. Diez-Martin; Dominique Bordessoule; Stephen Robinson; Peter Dreger
Blood | 2009
Eldad J. Dann; Rachel Bar-Shalom; Ada Tamir; Menachem Ben-Shachar; Irit Avivi; Tsila Zuckerman; Nuhad Haddad; Hanna Rosenbaum; Riva Fineman; Odelia Goor; Diana Libster; Zeev Blumenfeld; Jacob M. Rowe; Ron Epelbaum
Blood | 2012
Shimrit Ringelstein-Harlev; Irit Avivi; Lina Bisharat; Tamar Katz
Blood | 2012
Netanel Horowitz; Talya Wittmann; Jacob M. Rowe; Tsila Zuckerman; Irit Avivi
Blood | 2012
Irit Avivi; Talia Wittman; Noam Benyamini; Zipora Kra-Oz; Moran Szwrcwort; Ilana Oren; Jacob M. Rowe; Israel Henig; Tsila Zuckerman; Netanel Horowitz
Blood | 2011
Eldad J. Dann; Zeev Blumenfeld; Rachel Bar-Shalom; Irit Avivi; Menachem Ben-Shachar; Odelia Goor; Diana Libster; Diana Gaitini; Jacob M. Rowe; Ron Epelbaum
Blood | 2011
Hanna Rosenbaum; Irit Avivi; Eliezer A. Rachmilewitz; Paulina Petchenko
Blood | 2011
Tamar Katz; Noam Bettman; Hanna Rosenbaum; Irit Avivi
Collaboration
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