Irving Glickman

Protein deprivation and the periodontal structures of the albino rat

Abstract An experiment was conducted in the albino rat to evaluate the changes in the periodontal tissues associated with protein deprivation and to compare these changes with those observed in other areas of the skeletal system. The following changes resulted from protein deprivation: 1. a. 1.1. I. In the periodontal area, degeneration of connective tissue of the gingiva and periodontal membrane, osteoporosis of the alveolar bone, and retardation in the deposition of the cementum. 1.2. II. In the femur and vertebra, osteoporosis, marked inhibition of the endochondral and periosteal bone formation. 2. b. The changes observed in the periodontal membrane and alveolar bone were identical with those observed in the periosteum and bone in other areas of the skeletal system. 3. c. Osteoporosis in protein deprivation results from the following changes: reduced deposition of the osteoid, reduction in number of osteoblasts, and retardation in the morphodifferentiation of connective tissue cells to form osteoblasts. 4. d. Protein deprivation impedes endochondral bone formation by retarding the maturation and degeneration of cartilage cells and formation of osteoid.

An epithelial-like cell line in continuous culture from normal adult human gingiva.

Summary An epithelial-like cell line has been established from an area of clinically normal adult human attached gingiva, It has a generative time of approximately 24 hours in logarithmic phase and a plating efficiency of about 80-90%.

Occlusion and the Periodontium

The sponsor of the IADR Award for Basic Research in Periodontal Disease is the Colgate-Palmolive Company. The 1966 recipient of the Award for Basic Science in Periodontal Disease is Irving Glickman of the staff of Tufts University School of Dental Medicine. Doctor Glickman has demonstrated the relationship of systemic and local factors in experimental animals and the metabolic effects of steroid hormones on the periodontal tissues. His studies also helped to clarify the difference in oxygen consumption in normal and inflamed tissues, and his experiments pioneered research in tooth splintering in the treatment of periodontal disease. -G. C. PAFFENBARGER

Healing of the periodontium following mucogingival surgery

Abstract A study was conducted on dogs to compare the outcome of mucogingival surgery with and without removal of the periosteum. The width of the attached gingiva following the surgical procedure could not be predetermined by removing the periosteum or leaving it intact. Removing the periosteum during mucogingival surgery delayed healing and caused a significant loss in the height of the alveolar bone.

The Oxygen Consumption of Healing Gingiva

information regarding the details of gingival repair following gingivectomy. The demonstration of the applicability of the Warburg technic8 for the determination of the oxygen consumption of normal and inflamed gingiva suggested an additional approach to the subject of gingival repair. A correlated study of oxygen consumption and histological changes in the course of gingival healing was undertaken, therefore, in an effort to augment existing knowledge by revealing an additional aspect of the gingival repair process.

Intraoral occlusal telemetry. Part II. Registration of tooth contacts in chewing and swallowing

Abstract Recordings of tooth contacts produced by an intraoral miniature electronic telemetry system placed in the natural teeth during chewing and swallowing have been presented and explained.

The healing of extraction wounds in the presence of retained root remnants and bone fragments

Abstract In 18 young adult male and female albino rats, 22 maxillary first molars were extracted in such a manner as to permit the retention of the apical portion of one or more root remnants and bone fragments. The animals were sacrificed at periods ranging from one to one hundred eight days after the extractions. The microscopic findings in the course of healing in the presence of retained root remnants and bone fragments were analyzed.

A histochemical study of the keratotic process in oral lesions diagnosed clinically as leukoplakia

Abstract The keratotic process was studied microscopically and histochemically in eighty oral lesions diagnosed clinically as leukoplakia. In all lesions the stratum corneum was thickened and presented varied degrees of hyperkeratosis or parakeratosis, separately or in combination. Several histochemical differences between the hyperkeratotic and parakeratotic lesions were noted. Of particular interest was the observation that hyperkeratotic lesions were characterized by an increase in disulfides and a diminution in sulfhydryls in the stratum corneum which did not occur in parakeratotic lesions. An intermittent type of keratosis was also described.

Intraoral occlusal telemetry part I. A multifrequency transmitter for registering tooth contacts in occlusion

Abstract An intraoral occlusal telemetry system has been developed utilizing a miniature multifrequency transmitter which broadcasts at three different frequencies, registers tooth contacts on three different surfaces of the same tooth, and coordinates tooth contacts with swallowing. The transmitter is small enough to fit into a pontic replacing a single mandibular molar.

Intraoral occlusal telemetry. Part IV. Tooth contact during swallowing

Abstract Monitoring the occlusion with miniaturized intraoral radio transmitters revealed that contacts of teeth during swallowing occurred more often in centric occlusion rather than in centric relation with ratio of 182 to 5.