Irving Rothchild

Estrogenic Effect of Tri-p-anisylchloroethylene (TAGE)∗ in the Human Postmenopausal Female

Conclusions The minimal effective dose of TACE after oral administration required for virtually complete cornification of the postmenopausal human female vagina is in the neighborhood of 24 to 48 mg administered as 4 daily doses of 6 to 12 mg each. Similar amounts of TACE administered on alternate days do not induce much cornification of the vaginal mucosa, but do lead to some growth of the intermediate cell layers. The duration of effect of these minimal effective doses of TACE was not remarkably different from that of other oral estrogens (ethinyl estradiol, dienestrol), but it is possible that its prolonged effect appears only with doses greater than the minimal ones.